Nanodiamond-enhanced MRI via in situ hyperpolarization

Waddington, David E. J.; Sarracanie, Mathieu; Zhang, Huiliang; Salameh, Najat; Glenn, David; Rej, Ewa; Gaebel, T.; Boele, Thomas; Walsworth, Ronald L.; Reilly, David; Rosen, Matthew S.

doi:10.1038/ncomms15118

Cited by 85 publications

(79 citation statements)

References 62 publications

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“…Increasing B 1e , voxel size and AT are straightforward approaches to improving the concentration sensitivity of our platform. However, significantly increasing in vivo ATs would require the use of radicals with longer‐term in vivo stability . NMR sensitivity would be further improved by reducing coil noise, by implementing either a cryocooled coil or active feedback …”

Section: Discussionmentioning

confidence: 99%

An Overhauser‐enhanced‐MRI platform for dynamic free radical imaging in vivo

et al. 2018

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Overhauser-enhanced MRI (OMRI) is an electron-proton double-resonance imaging technique of interest for its ability to non-invasively measure the concentration and distribution of free radicals. In vivo OMRI experiments are typically undertaken at ultra-low magnetic field (ULF), as both RF power absorption and penetration issues-a consequence of the high resonance frequencies of electron spins-are mitigated. However, working at ULF causes a drastic reduction in MRI sensitivity. Here, we report on the design, construction and performance of an OMRI platform optimized for high NMR sensitivity and low RF power absorbance, exploring challenges unique to probe design in the ULF regime. We use this platform to demonstrate dynamic imaging of TEMPOL in a rat model. The work presented here demonstrates improved speed and sensitivity of in vivo OMRI, extending the scope of OMRI to the study of dynamic processes such as metabolism.

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Section: Discussionmentioning

confidence: 99%

An Overhauser‐enhanced‐MRI platform for dynamic free radical imaging in vivo

et al. 2018

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“…Hyperpolarization is a new method, based on the Overhauser effect, which is promising to improve MRI contrast for nanodiamonds . Basically, the technique transfers spin polarization from paramagnetic impurities at nanodiamond surfaces to 1H spins in the surrounding water solution, in order to create MRI contrast on demand.…”

Section: Labelingmentioning

confidence: 99%

Nanodiamonds and Their Applications in Cells

Chipaux

Laan

Hemelaar

et al. 2018

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Diamonds owe their fame to a unique set of outstanding properties. They combine a high refractive index, hardness, great stability and inertness, and low electrical but high thermal conductivity. Diamond defects have recently attracted a lot of attention. Given this unique list of properties, it is not surprising that diamond nanoparticles are utilized for numerous applications. Due to their hardness, they are routinely used as abrasives. Their small and uniform size qualifies them as attractive carriers for drug delivery. The stable fluorescence of diamond defects allows their use as stable single photon sources or biolabels. The magnetic properties of the defects make them stable spin qubits in quantum information. This property also allows their use as a sensor for temperature, magnetic fields, electric fields, or strain. This Review focuses on applications in cells. Different diamond materials and the special requirements for the respective applications are discussed. Methods to chemically modify the surface of diamonds and the different hurdles one has to overcome when working with cells, such as entering the cells and biocompatibility, are described. Finally, the recent developments and applications in labeling, sensing, drug delivery, theranostics, antibiotics, and tissue engineering are critically discussed.

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“…[18][19][20][21][22][23] Nanodiamonds are a promising nanomaterial for biomedical applications, especially as a delivery platform for cancer therapeutics and diagnostic agents. [34][35][36][37][38][39] The nature of the therapeutic or diagnostic agent being delivered by NDs is largely dependent on specific chemical modifications and drug-loading strategies unique for each cargo. [26][27][28][29][30][31][32][33] As a drug-delivery platform, NDs can deliver a wide range of clinically relevant cargo, including chemotherapy drugs, www.advancedsciencenews.com www.advtherap.com small molecules, proteins, genetic materials, as well as imaging agents.…”

Section: Doi: 101002/adtp201800110mentioning

confidence: 99%

Nanodiamond‐Based Platform for Intracellular‐Specific Delivery of Therapeutic Peptides against Hepatocellular Carcinoma

Wang

Toh

et al. 2018

Advanced Therapeutics

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Therapeutic peptides are attractive as a treatment modality due to their high selectivity and relative safety and tolerability. Delivery of therapeutic peptides to target cells continues to pose a challenge, particularly when these peptides target intracellular proteins. In this study, the use of nanodiamonds (NDs) as a platform for enhanced intracellular delivery of therapeutic peptides is investigated. SALL4 is found to contribute to tumor progression in many types of cancers, including hepatocellular carcinoma (HCC). Therapeutic peptides specifically targeting SALL4 demonstrate an effective, but limited, inhibitory effect on SALL4-driven HCC tumor cell growth. Nanodiamond-based delivery of SALL4-inhibitory peptides is found to improve peptide stability and cellular peptide retention. Stimuli-responsive release of SALL4-inhibitory peptide from nanodiamonds ensures intracellular-specific delivery of functional SALL4-inhibitory peptides. The observed enhanced peptide stability and intracellular-specific delivery of SALL4-inhibitory peptides by nanodiamonds result in improved therapeutic efficacy by ND-peptide complexes against SALL4-driven HCC. As such, nanodiamonds serve as a promising platform for stimuli-responsive intracellular-specific delivery of therapeutic peptides.Therapeutic peptides have been applied toward treating a wide range of diseases. [1][2][3][4][5][6] Various therapeutic applications of peptides include serving as hormones, inhibitors, drug carriers, and even anticancer agents. [1][2][3][4][7][8][9][10][11][12][13] However, hurdles toward clinical implementation for some peptides exist due to the intrinsic

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Nanodiamond-enhanced MRI via in situ hyperpolarization

Cited by 85 publications

References 62 publications

An Overhauser‐enhanced‐MRI platform for dynamic free radical imaging in vivo

An Overhauser‐enhanced‐MRI platform for dynamic free radical imaging in vivo

Nanodiamonds and Their Applications in Cells

Nanodiamond‐Based Platform for Intracellular‐Specific Delivery of Therapeutic Peptides against Hepatocellular Carcinoma

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