Nanodiamond-conjugated transferrin as chemotherapeutic drug delivery

Wang, Zhiqin; Tian, Zhonghuan; Dong, Yu; Li, Lin; Tian, Ling; Li, Yingqi; Yang, Binsheng

doi:10.1016/j.diamond.2015.06.008

Cited by 42 publications

(28 citation statements)

References 37 publications

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“…An alternative for folic acid that has been utilized is transferrin. It accumulates in certain tumors since they actively express receptors for this molecule on the cell membrane …”

Section: Diamonds For In Vivo Applicationsmentioning

confidence: 99%

Nanodiamonds for In Vivo Applications

Laan

Hasani

Zheng

et al. 2018

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157

127

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Due to their unique optical properties, diamonds are the most valued gemstones. However, beyond the sparkle, diamonds have a number of unique properties. Their extreme hardness gives them outstanding performance as abrasives and cutting tools. Similar to many materials, their nanometer-sized form has yet other unique properties. Nanodiamonds are very inert but still can be functionalized on the surface. Additionally, they can be made in very small sizes and a narrow size distribution. Nanodiamonds can also host very stable fluorescent defects. Since they are protected in the crystal lattice, they never bleach. These defects can also be utilized for nanoscale sensing since they change their optical properties, for example, based on temperature or magnetic fields in their surroundings. In this Review, in vivo applications are focused upon. To this end, how different diamond materials are made and how this affects their properties are discussed first. Next, in vivo biocompatibility studies are reviewed. Finally, the reader is introduced to in vivo applications of diamonds. These include drug delivery, aiding radiology, labeling, and use in cosmetics. The field is critically reviewed and a perspective on future developments is provided.

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“…An alternative for folic acid that has been utilized is transferrin. It accumulates in certain tumors since they actively express receptors for this molecule on the cell membrane …”

Section: Diamonds For In Vivo Applicationsmentioning

confidence: 99%

Nanodiamonds for In Vivo Applications

Laan

Hasani

Zheng

et al. 2018

Small

157

127

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“…Thus, FNDs can target particular biological structures in vivo. The application of FNDs for drug delivery [13,14] as well as for cell labeling in general has been studied [15,16]. FNDs can furthermore be used to enhance existing imaging techniques, such as MRI [17] or fluorescence microscopy [18][19][20][21].…”

Section: Fluorescent Nanodiamondsmentioning

confidence: 99%

3D tomographic magnetofluorescence imaging of nanodiamonds

Frese

Schiller

2020

Biomed. Opt. Express

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We demonstrate lensless imaging of three-dimensional phantoms of fluorescent nanodiamonds in solution. Magnetofluorescence imaging is employed, which relies on a dependence of the fluorescence yield on the magnetic field, and pervading the object with an inhomogeneous magnetic field. This field provides a field-free field line, which is rastered through the object. A 3D image of the object is obtained by imaging a set of 2D slices. Each 2D slice image is computed from a set of 1D projections, obtained under different projection directions, using a backprojection algorithm. Reconstructed images containing up to 36 × 36 × 8 voxels are obtained. A spatial resolution better than 2 mm is achieved in three dimensions. The approach has the potential for scalability.

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“…Although there have already been several successful attempts to use ND for drug delivery, [34][35][36] in nearly all of these examples, researchers attached the drugs to the surface of the ND. When the drugs are exposed to physiological environments, they may cause side effects to the human body or drug failure.…”

Section: Introductionmentioning

confidence: 99%