Nanodiamond as Promising Material for Bone Tissue Engineering

Grausova, Lubica; Bačáková, Lucie; Kromka, Alexander; Potocký, Štěpán; Vaněček, M.; Nesládek, Miloš; Vaccari, Lisa

doi:10.1166/jnn.2009.ns26

Cited by 74 publications

(47 citation statements)

References 36 publications

(82 reference statements)

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“…However, this effect was only to be observed with the high-dose inoculum. In all cases, d 10 caused significantly stronger foot swelling than d 50 or d 1,000 (Fig. 4 B and C).…”

Section: Size-dependent Induction Of Inflammation and Immune Responsementioning

confidence: 84%

“…However, the following are well known. (i) Nanodiamond films support adhesion and differentiation of osteogenic cells, being candidates for surface modification of implants to improve their integration into the bone (1). The recent development of fullerenes and carbon nanotubes holds high technical potential and may considerably increase the contact of nanomaterial with the biosphere (2).…”

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confidence: 99%

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Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Muñoz

Bilyy

Biermann

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

129

118

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The critical size for strong interaction of hydrophobic particles with phospholipid bilayers has been predicted to be 10 nm. Because of the wide spreading of nonpolar nanoparticles (NPs) in the environment, we aimed to reveal the ability of living organisms to entrap NPs via formation of neutrophil extracellular traps (NETs). Upon interaction with various cell types and tissues, 10-to 40-nmsized NPs induce fast (<20 min) damage of plasma membranes and instability of the lysosomal compartment, leading to the immediate formation of NETs. In contrast, particles sized 100-1,000 nm behaved rather inertly. Resulting NET formation (NETosis) was accompanied by an inflammatory reaction intrinsically endowed with its own resolution, demonstrated in lungs and air pouches of mice. Persistence of small NPs in joints caused unremitting arthritis and bone remodeling. Small NPs coinjected with antigen exerted adjuvant-like activity. This report demonstrates a cellular mechanism that explains how small NPs activate the NETosis pathway and drive their entrapping and resolution of the initial inflammatory response.nanoparticles | size | neutrophils | NETosis | inflammation

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“…However, this effect was only to be observed with the high-dose inoculum. In all cases, d 10 caused significantly stronger foot swelling than d 50 or d 1,000 (Fig. 4 B and C).…”

Section: Size-dependent Induction Of Inflammation and Immune Responsementioning

confidence: 84%

mentioning

confidence: 99%

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Muñoz

Bilyy

Biermann

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

129

118

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“…30,31 Some studies have also been focused on differentiation of neural stem cells, for which a hydrogenated NCD surface supports differentiation into neurons while an oxygenated NCD surface supports differentiation towards oligodendrocytes. 32,33 The process of osteoblast differentiation and ECM production may determine the osteoconductivity of the biomaterial.…”

Section: Discussionmentioning

confidence: 99%

Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

Lišková¹,

Babchenko²,

Varga³

et al. 2015

IJN

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Nanocrystalline diamond (NCD) films are promising materials for bone implant coatings because of their biocompatibility, chemical resistance, and mechanical hardness. Moreover, NCD wettability can be tailored by grafting specific atoms. The NCD films used in this study were grown on silicon substrates by microwave plasma-enhanced chemical vapor deposition and grafted by hydrogen atoms (H-termination) or oxygen atoms (O-termination). Human osteoblast-like Saos-2 cells were used for biological studies on H-terminated and O-terminated NCD films. The adhesion, growth, and subsequent differentiation of the osteoblasts on NCD films were examined, and the extracellular matrix production and composition were quantified. The osteoblasts that had been cultivated on the O-terminated NCD films exhibited a higher growth rate than those grown on the H-terminated NCD films. The mature collagen fibers were detected in Saos-2 cells on both the H-terminated and O-terminated NCD films; however, the quantity of total collagen in the extracellular matrix was higher on the O-terminated NCD films, as were the amounts of calcium deposition and alkaline phosphatase activity. Nevertheless, the expression of genes for osteogenic markers – type I collagen, alkaline phosphatase, and osteocalcin – was either comparable on the H-terminated and O-terminated films or even lower on the O-terminated films. In conclusion, the higher wettability of the O-terminated NCD films is promising for adhesion and growth of osteoblasts. In addition, the O-terminated surface also seems to support the deposition of extracellular matrix proteins and extracellular matrix mineralization, and this is promising for better osteoconductivity of potential bone implant coatings.

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“…Additionally, NDs' surface can be modified with targeting biological signals to achieve a selective cellular internalization of chemotherapeutic agents as well as genetic materials. Aside from their role as carriers in drug and gene delivery, NDs have been widely explored as nanofillers to improve the physical and mechanical properties of both natural and synthetic scaffolds [6,7]. Specifically, NDs have found application in the field of bone tissue engineering as reinforcing nanomaterial to design nanocomposite systems necessary to promote bone regeneration.…”

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confidence: 99%

Adoption of nanodiamonds as biomedical materials for bone repair

et al. 2017

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Keywords: gene/drug delivery • nanodiamonds • therapeutics Nanodiamonds (NDs) are an emerging class of biologically compatible carbon-based nanomaterials that possess a set of unique properties essential for the design of innovative therapies in the fields of drug delivery, tissue engineering and bioimaging [1]. For instance, the high surface area along with the tunable surface chemistry enables the physical adsorption or covalent conjugation of a variety of therapeutic molecules, such as drugs, peptides and growth factors [2][3][4][5]. Additionally, NDs' surface can be modified with targeting biological signals to achieve a selective cellular internalization of chemotherapeutic agents as well as genetic materials. Aside from their role as carriers in drug and gene delivery, NDs have been widely explored as nanofillers to improve the physical and mechanical properties of both natural and synthetic scaffolds [6,7]. Specifically, NDs have found application in the field of bone tissue engineering as reinforcing nanomaterial to design nanocomposite systems necessary to promote bone regeneration. This editorial emphasizes on the current state-of-the-art research using NDs in the field of bone repair, with a focus on the recent breakthroughs such as precise immobilization of growth factors and peptides. Biomolecule immobilization via surface functionalization of NDsNDs are carbon-based nanomaterials, which possess a set of unique properties that enables their use in a variety of applications including drug delivery, tissue engineering and bioimaging. This advantage has encouraged scientists to investigate NDs for a broad range of applications [8] in regenerative medicine with a primary focus on bone tissue engineering. NDs possess versatile surface functionalities and they can be loaded with virtually any type of biomolecule, thereby enabling their use as delivery vehicles in bone-healing applications [9]. The presence of surface functional groups can efficiently control the interfacial reactions between the nanoparticle and the active biomolecule, eventually maximizing the therapeutic efficiency of the delivered biomaterial. The initial functional groups present on the surface of NDs, following the formation of the nanoparticle, vary according to the selected synthesis and purification methods. For example, hydrogen-assisted chemical vapor deposition generates NDs bearing hydrogen-terminated surfaces. On the other hand, methods, such as detonation synthesis, introduce a highly diverse surface chemistry, with functional groups such as hydroxyl, carbonyl, ether and carboxyl groups. It is essential to maintain a similar functionality throughout the entire surface to enable further surface reactions. Thus, chemical treatment of the NDs is often required to create homogenized reactive surfaces. Among the possible alternatives, carboxylation, hydroxylation or hydrogenation are the commonly investigated routes to generate -COOH and -OH groups on the surface. Due to the presence of these diverse functionalities on the surfac...

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Nanodiamond as Promising Material for Bone Tissue Engineering

Cited by 74 publications

References 36 publications

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

Adoption of nanodiamonds as biomedical materials for bone repair

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