Nanodiagnostics: New Tools for Detection of Animal Pathogens

Hassan, Atef A.; Sayed-ElAhl, Rasha M.H.; Hamaky, Ahmed M. El; Mansour, Mogda K.; Oraby, Noha H.; Barakat, Mahmoud H.

doi:10.1007/978-3-031-16084-4_13

Cited by 2 publications

(2 citation statements)

References 144 publications

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“…In addition to rapid results, these devices are often more economical for diagnostic purposes. Moreover, nanobiosensors can detect multiple analytes simultaneously, making them suitable for detecting complex diseases like echinococcosis [ 41 ]. Researchers need to explore the potential for nanobiosensors to revolutionize the detection and management of echinococcosis.…”

Section: Introductionmentioning

confidence: 99%

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Hajjafari,

Sadr,

Santucciu

et al. 2024

Veterinary Sciences

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Cystic echinococcosis (CE) is a zoonotic disease affecting humans and animals. Despite a lack of clarity about many details of parasite–intermediate host interactions, the nature of the immune responses triggered by hydatid infection has revealed new perspectives. This study discusses the latest advances in elucidating the immunologic mechanism of echinococcosis and its detection and potential approaches to enhance serodiagnosis accuracy. Moreover, nanobiosensors have been evaluated according to their potential to improve treatment efficiency and aid in an early diagnosis of cystic echinococcosis. The serum of an intermediate host can diagnose CE by analyzing antibodies induced by Echinococcus granulosus. Among the most notable features of this method are its noninvasive ability and high sensitivity, both of which make it an excellent tool for clinical diagnosis. Several serological tests, including ELISAs and immunoblotting, can detect these antibodies to assess the disease’s state and determine the treatment outcome. A thorough understanding of what cross-reactivity means and the stage of the disease are crucial to interpreting serological results. Nanobiosensors have also proven better than conventional biosensors in detecting hydatid cysts. Additionally, they are highly sensitive and versatile when detecting specific biomarkers, improving diagnostic accuracy. These immunomodulatory molecules, induced by E. granulosus, are a good candidate for diagnosing cystic echinococcosis because they alter intermediate host immune responses. Hydatid cyst detection is also enhanced through nanobiosensors, which provide better accuracy.

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Section: Introductionmentioning

confidence: 99%

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Hajjafari,

Sadr,

Santucciu

et al. 2024

Veterinary Sciences

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“…A further advantage of these nanoscale devices is that they enable rapid and non-invasive detection, which can be especially helpful for early-stage cysts, which conventional treatments would otherwise miss [55]. Through the integration of nanobiosensors with imaging technology, this technology has the potential to revolutionize hydatid cyst diagnosis [56].…”

Section: Introductionmentioning

confidence: 99%

Challenges and Prospective of Enhancing Hydatid Cyst Chemotherapy by Nanotechnology and the Future of Nanobiosensors for Diagnosis

Sadr,

Lotfalizadeh,

Abbasi

et al. 2023

TropicalMed

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Hydatid cysts have been widely recognized for decades as a common medical problem that affects millions of people. A revolution in medical treatment may be on the prospect of nanotechnology enhancing chemotherapy against hydatid cysts. An overview of nanotechnology’s impact on chemotherapeutics is presented in the current review. It discusses some of the challenges as well as some of the opportunities. The application of nanotechnology to enhance chemotherapy against hydatid cysts is what this review will explore. Nanotechnology is a critical component of delivering therapeutic agents with greater precision and efficiency and targeting hydatid cysts with better efficacy, and minimizing interference with surrounding tissue. However, there are biodistribution challenges, toxicity, and resistance problems associated with nanotherapeutics. Additionally, nanobiosensors are being investigated to enable the early diagnosis of hydatid cysts. A nanobiosensor can detect hydatid cysts by catching them early, non-invasively, rapidly, and accurately. The sensitivity and specificity of diagnostic tests can be enhanced with nanobiosensors because they take advantage of the unique properties of nanomaterials. By providing more precise and customized treatment options for hydatid cysts, nanotechnology may improve therapeutic options and strategies for diagnosing the disease. In conclusion, treatment with nanotechnology to treat hydatid cysts is potentially effective but presents many obstacles. Furthermore, nanobiosensors are being integrated into diagnostic techniques, as well as helping to diagnose patients earlier and more accurately.

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Nanodiagnostics: New Tools for Detection of Animal Pathogens

Cited by 2 publications

References 144 publications

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Challenges and Prospective of Enhancing Hydatid Cyst Chemotherapy by Nanotechnology and the Future of Nanobiosensors for Diagnosis

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