Nanodelivery Systems for Mucosal Vaccines

Kim, Mi‐Gyeong; Park, Joo Yeon; Shon, Yuna; Kim, Young Bong; Oh, Yu‐Kyoung

doi:10.2174/18779123113036660001

Cited by 1 publication

(1 citation statement)

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“…The limitations encountered by the mucosal vaccine delivery systems, such as pH and degradation by enzymes, can be overcome by the use of nanocarriers with the advantages of being nano-sized, biodegradable, and biocompatible and have cell-specific targeting ability. These nanocarriers enhance immunogenicity and prolong retention time at mucosal sites ( Kim et al, 2013 ).…”

Section: Needle-free Vaccine Delivery Systemmentioning

confidence: 99%

Nanocarriers-Assisted Needle-Free Vaccine Delivery Through Oral and Intranasal Transmucosal Routes: A Novel Therapeutic Conduit

et al. 2022

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Drug delivery using oral route is the most popular, convenient, safest and least expensive approach. It includes oral transmucosal delivery of bioactive compounds as the mucosal cavity offers an intriguing approach for systemic drug distribution. Owing to the dense vascular architecture and high blood flow, oral mucosal layers are easily permeable and can be an ideal site for drug administration. Recently, the transmucosal route is being investigated for other therapeutic candidates such as vaccines for their efficient delivery. Vaccines have the potential to trigger immune reactions and can act as both prophylactic and therapeutic conduit to a variety of diseases. Administration of vaccines using transmucosal route offers multiple advantages, the most important one being the needle-free (non-invasive) delivery. Development of needle-free devices are the most recent and pioneering breakthrough in the delivery of drugs and vaccines, enabling patients to avoid needles, reducing anxiety, pain and fear as well as improving compliance. Oral, nasal and aerosol vaccination is a novel immunization approach that utilizes a nanocarrier to administer the vaccine. Nanocarriers improve the bioavailability and serve as adjuvants to elicit a stronger immune response, resulting in increased effectiveness of vaccination. Drugs and vaccines with lower penetration abilities can also be delivered transmucosally while maintaining their biological function. The development of micro/nanocarriers for transmucosal delivery of macromolecules, vaccines and other substances is currently drawing much attention and a number of studies were performed recently. This comprehensive review is aimed to summarize the most recent investigations on needle-free and non-invasive approaches for the delivery of vaccines using oral transmucosal route, their strengths and associated challenges. The oral transmucosal vaccine delivery by nanocarriers is the most upcoming advancement in efficient vaccine delivery and this review would help further research and trials in this field.

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Section: Needle-free Vaccine Delivery Systemmentioning

confidence: 99%