Nanodelivery of Resveratrol-Loaded PLGA Nanoparticles for Age-Related Macular Degeneration

Bhatt, Priyanka; Fnu, Gulimirerouzi; Bhatia, Deepak; Shahid, Amna; Sutariya, Vijaykumar

doi:10.1208/s12249-020-01836-4

Cited by 49 publications

(21 citation statements)

References 27 publications

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“…Two strategies were followed to endow CLs with antibiofilm features: copolymerization with MPC and loading of resveratrol. To the best of our knowledge, resveratrol-eluting CLs have not been previously investigated, although resveratrol may find applications in the ocular field as an antioxidant, anti-inflammatory, antiangiogenic and anticarcinogenic agent [33,46,47]. MPC is a component of one commercially available soft (HEMA-based) CL brand (Proclear ® ) that claims to retain more water on its surface.…”

Section: Hydrogel Synthesismentioning

confidence: 99%

“…This work relies on the hypothesis that the design of hydrogels containing MPC moieties and incorporating resveratrol may exhibit a synergism in terms of the prevention of biofilm formation on CLs, while resveratrol may also lead to other beneficial effects related to its antioxidant capability. Some eye diseases caused by oxidative stress mechanisms, such as age-related macular degeneration, cataracts and glaucoma, may be treated or prevented with antioxidants [23,33]. To the best of our knowledge, loading of resveratrol in CLs has not been tested before.…”

Section: Introductionmentioning

confidence: 99%

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Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

et al. 2021

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Contact lenses (CLs) are prone to biofilm formation, which may cause severe ocular infections. Since the use of antibiotics is associated with resistance concerns, here, two alternative strategies were evaluated to endow CLs with antibiofilm features: copolymerization with the antifouling monomer 2-methacryloyloxyethyl phosphorylcholine (MPC) and loading of the antioxidant resveratrol with known antibacterial activity. MPC has, so far, been used to increase water retention on the CL surface (Proclear® 1 day CLs). Both poly(hydroxyethyl methacrylate) (HEMA) and silicone hydrogels were prepared with MPC covering a wide range of concentrations (from 0 to 101 mM). All hydrogels showed physical properties adequate for CLs and successfully passed the hen's egg-chorioallantoic membrane (HET-CAM) test. Silicone hydrogels had stronger affinity for resveratrol, with higher loading and a slower release rate. Ex vivo cornea and sclera permeability tests revealed that resveratrol released from the hydrogels readily accumulated in both tissues but did not cross through. The antibiofilm tests against Pseudomonas aeruginosa and Staphylococcus aureus evidenced that, in general, resveratrol decreased biofilm formation, which correlated with its concentration-dependent antibacterial capability. Preferential adsorption of lysozyme, compared to albumin, might also contribute to the antimicrobial activity. In addition, importantly, the loading of resveratrol in the hydrogels preserved the antioxidant activity, even against photodegradation. Overall, the designed hydrogels can host therapeutically relevant amounts of resveratrol to be sustainedly released on the eye, providing antibiofilm and antioxidant performance.

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Section: Hydrogel Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

et al. 2021

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“…As elucidated in this review, novel small molecule antioxidant treatments for macular disease like dry and neovascular AMD have demonstrated efficacy within in vitro, in vivo, and preclinical disease models but few have been tested in later phase clinical studies. 2 , 46 , 49 , 52 , 59 , 61 , 66 This represents a knowledge gap regarding the clinical evidence needed to proceed with the development of new efficacious antioxidant treatments. Still, when we consider the evidence reviewed here, we can state that the most promising treatments will be those that prevent apoptosis induced by oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence

Wang¹,

Chin²,

Almeida³

2021

OPTH

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Retinal tissue is prone to oxidant burden and oxidative stress secondary to the generation of reactive oxygen species from high metabolic demand. The formation of reactive oxygen species occurs primarily from the mitochondrial respiratory chain as well as several enzymatic and oxidation reactions that occur in the neurosensory retina and retinal pigment epithelium. This oxidative stress has been implicated in the pathogenesis of several retinal diseases and the role of antioxidants as a therapeutic treatment shows promise in slowing the progression of certain diseases. The aim of this narrative review is to describe the mechanisms of retinal oxidative stress and summarize the current available evidence for antioxidants as a treatment for vitreoretinal disorders.

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“…Many formulations have been developed to efficiently deliver RSV into the eye, including nanoparticle complexation and lipid-based encapsulation. In a cellular model of AMD with ARPE-19 cells, RSV was loaded in a poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticle, showing a potential cellular uptake and anti-angiogenic properties by inhibiting VEGF expression [ 173 ]. With regards to the safety of RVS, adverse effects are still unknown; however, no associated toxicity has been reported so far in in vitro or in vivo studies, and RSV has been well tolerated in clinical trials [ 147 ].…”

Section: New Therapeutics For Amdmentioning

confidence: 99%

Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Age Related Macular Degeneration, Role in Pathophysiology, and Possible New Therapeutic Strategies

et al. 2021

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Age related macular degeneration (AMD) is the main cause of legal blindness in developed countries. It is a multifactorial disease in which a combination of genetic and environmental factors contributes to increased risk of developing this vision-incapacitating condition. Oxidative stress plays a central role in the pathophysiology of AMD and recent publications have highlighted the importance of mitochondrial dysfunction and endoplasmic reticulum stress in this disease. Although treatment with vascular endothelium growth factor inhibitors have decreased the risk of blindness in patients with the exudative form of AMD, the search for new therapeutic options continues to prevent the loss of photoreceptors and retinal pigment epithelium cells, characteristic of late stage AMD. In this review, we explain how mitochondrial dysfunction and endoplasmic reticulum stress participate in AMD pathogenesis. We also discuss a role of several antioxidants (bile acids, resveratrol, melatonin, humanin, and coenzyme Q10) in amelioration of AMD pathology.

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Nanodelivery of Resveratrol-Loaded PLGA Nanoparticles for Age-Related Macular Degeneration

Cited by 49 publications

References 27 publications

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence

Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Age Related Macular Degeneration, Role in Pathophysiology, and Possible New Therapeutic Strategies

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