Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis

Dolati, Sanam; Babaloo, Zohreh; Ayromlou, Hormoz; Ahmadi, Majid; Rikhtegar, Reza; Rostamzadeh, Davoud; Roshangar, Leila; Nouri, Mohammad; Mehdizadeh, Amir; Younesi, Vahid; Yousefi, Mehdi

doi:10.1016/j.jneuroim.2019.01.007

Cited by 77 publications

(49 citation statements)

References 23 publications

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“…Moreover, curcumin-loaded nanoparticles promoted myelin repair in a model of demyelination induced by lysolecithin in the rat corpus callosum 47 . Of note, nanocurcumin was recently shown to reduce neuroinflammation and restore dysregulated Treg functions in a clinical trial enrolling 50 relapsing-remitting MS subjects, after six months of treatment 48,49 .…”

Section: Discussionmentioning

confidence: 99%

Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ

Bernardo

Plumitallo

Nuccio

et al. 2021

Sci Rep

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Curcumin is a compound found in the rhizome of Curcuma longa (turmeric) with a large repertoire of pharmacological properties, including anti-inflammatory and neuroprotective activities. The current study aims to assess the effects of this natural compound on oligodendrocyte progenitor (OP) differentiation, particularly in inflammatory conditions. We found that curcumin can promote the differentiation of OPs and to counteract the maturation arrest of OPs induced by TNF-α by a mechanism involving PPAR-γ (peroxisome proliferator activated receptor), a ligand-activated transcription factor with neuroprotective and anti-inflammatory capabilities. Furthermore, curcumin induces the phosphorylation of the protein kinase ERK1/2 known to regulate the transition from OPs to immature oligodendrocytes (OLs), by a mechanism only partially dependent on PPAR-γ. Curcumin is also able to raise the levels of the co-factor PGC1-α and of the cytochrome c oxidase core protein COX1, even when OPs are exposed to TNF-α, through a PPAR-γ-mediated mechanism, in line with the known ability of PPAR-γ to promote mitochondrial integrity and functions, which are crucial for OL differentiation to occur. Altogether, this study provides evidence for a further mechanism of action of curcumin besides its well-known anti-inflammatory properties and supports the suggested therapeutic potential of this nutraceutical in demyelinating diseases.

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Section: Discussionmentioning

confidence: 99%

Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ

Bernardo

Plumitallo

Nuccio

et al. 2021

Sci Rep

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“…Recently, Ahmadi et al conducted a clinical trial and showed that nanocurcumin is a safe and effective treatment in patients with amyotrophic lateral sclerosis (Ahmadi et al, 2018). Another clinical trial conducted by Dolati et al suggested that nanocurcumin is capable of restoring the frequency and function of treg cells in multiple sclerosis patients (Dolati et al, 2019).…”

Section: Clinical Trials and Patentsmentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

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“…According to the abovementioned results, nano-curcumin plays an important role as an immunomodulatory agent and prevents auto reactivity through its effect on frequency and function of Treg cells. 93 A double-blind, randomized, placebo-controlled trial was also performed to investigate the efficacy of nano-curcumin (80 mg/kg) in patients with ALS. The survival probability of patients with ALS was significantly improved over the 12-month period of this study.…”

Section: Application Of Nano-curcumin In Clinical Trialsmentioning

confidence: 99%

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

Yavarpour-Bali¹,

Ghasemi-Kasman²,

Pirzadeh³

2019

IJN

214

123

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Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also possesses remarkable anti-inflammatory and neuroprotective effects with the ability to pass from the blood brain barrier. Based on several pharmacological activities of curcumin, it has been introduced as an ideal candidate for different neurological disorders. Despite the pleiotropic activities of curcumin, poor solubility, rapid clearance and low stability have limited its clinical application. In recent years, nano-based drug delivery system has effectively improved the aqueous solubility and bioavailability of curcumin. In this review article, the effects of curcumin nanoparticles and their possible mechanism/s of action has been elucidated in various central nervous system (CNS)-related diseases including Parkinson's disease, Huntington disease, Alzheimer's disease, Multiple sclerosis, epilepsy and Amyotrophic Lateral Sclerosis. Furthermore, recent evidences about administration of nano-curcumin in the clinical trial phase have been described in the present review article.

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Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis

Cited by 77 publications

References 23 publications

Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ

Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ

Nanocurcumin: A Promising Candidate for Therapeutic Applications

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

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