Nanocrystalline silver dressings as an efficient anti-MRSA barrier: a new solution to an increasing problem

Strohal, Robert; Schelling, Marc; Takacs, Michael; Jurecka, Wolfgang; Gruber, U.; Offner, Felix

doi:10.1016/j.jhin.2005.04.001

Cited by 69 publications

(37 citation statements)

References 14 publications

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“…On the other hand, Askina Calgitrol Ag ® , which contains the highest silver concentration compared with all tested dressings [14], had the most equivalent efficacy to Acticoat ® . Since the silver form in Acticoat ® is nanocrystalline, the molecular size and concentration of silver are higher than those in other dressings [20,21]. Because of its nanocrystalline form, Acticoat ® also exhibits sustained-release of silver molecule resulting in longer duration of action.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Evaluation of the Antimicrobial Effectiveness and Moisture Binding Properties of Wound Dressings

Aramwit

Muangman

Namviriyachote

et al. 2010

IJMS

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A variety of silver-coated dressings and some impregnated with other chemicals are now available in the market; however, there have been few studies analyzing their comparative efficacies as antimicrobial agents. Moreover, their properties for retaining an appropriate level of moisture that is critical for effective wound healing have never been reported. Five commercially available silver-containing and chlorhexidine dressings, Urgotul SSD®, Bactigras®, Acticoat®, Askina Calgitrol Ag® and Aquacel Ag®, were tested to determine their comparative antimicrobial effectiveness in vitro against five common wound pathogens, namely methicillin-sensitive and -resistant Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. Mepitel®, a flexible polyamide net coated with soft silicone, was used as a control. The zones of inhibition and both the rapidity and the extent of killing of these pathogens were evaluated. All five antimicrobial dressings investigated exerted some bactericidal activity, particularly against E. coli. The spectrum and rapidity of action ranged widely for the different dressings. Acticoat® had a broad spectrum of action against both Gram-positive and -negative bacteria. Other dressings demonstrated a narrower range of bactericidal activities. Regarding the absorption and release of moisture, Askina Calgitrol Ag® absorbed and released the most moisture from the environment. Aquacel Ag® also exhibited good moisture absorption and moisture release, but to a lower degree. The other tested dressings absorbed or released very little moisture. Askina Calgitrol Ag® and Aquacel Ag® are good alternative dressings for treating wounds with high exudates and pus. An understanding of the characteristics of these dressings will be useful for utilizing them for specific requirements under specified conditions.

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Section: Resultsmentioning

confidence: 99%

In Vitro Evaluation of the Antimicrobial Effectiveness and Moisture Binding Properties of Wound Dressings

Aramwit

Muangman

Namviriyachote

et al. 2010

IJMS

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“…Again, Ag 7 NO 11 had a low MBC against planktonic populations, prevented biofilm formation, and eradicated established biofilms at lower concentrations than those of AgNO 3 and CuSO 4 . Certainly, Ag has been explored as a strategy to control infection by uropathogens (72) as well as to combat and control antibioticresistant pathogens, including MRSA (67,(73)(74)(75)(76). The results from this study demonstrated variable sensitivities of the planktonic and biofilm populations to CuSO 4 , AgNO 3 , and Ag 7 NO 11 .…”

Section: Discussionmentioning

confidence: 76%

Silver Oxynitrate, an Unexplored Silver Compound with Antimicrobial and Antibiofilm Activity

Lemire

Kalan

Bradu

et al. 2015

Antimicrob Agents Chemother

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bHistorically it has been accepted, and recent research has established, that silver (Ag) is an efficacious antimicrobial agent. A dwindling pipeline of new antibiotics, combined with an increase in the number of antibiotic-resistant infections, is bringing Ag to the fore as a therapeutic compound to treat infectious diseases. Currently, many formulations of Ag are being deployed for commercial and medical purposes, with various degrees of effectiveness at killing microbial cells. H istory has demonstrated that silver (Ag) is an efficacious antimicrobial agent, finding utility as an antiquated preservative for food and water (1, 2). Currently, Ͼ100 Ag-containing medical devices have been approved for use by the FDA (http: //www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn .cfm), and there is mounting evidence that Ag may be effective for preventing the spread of infectious disease (1,3,4). Although the toxicological profile of orally administered Ag remains to be resolved, topical application for the treatment of chronic wounds remains promising (5-8). Accordingly, Ag can address a timely public health issue, as chronic wounds represent a substantial financial and medical burden to the health care system. One of the hallmarks of a chronic wound is the presence of a biofilm, a factor that complicates wound healing and is hypothesized to be the fulcrum between the acute-to-chronic-wound transition (6, 9-15). Also, bacterial biofilms contaminate implanted medical devices (16) and exhibit high-level resistance to conventional antibiotics (17-23). New antibiofilm agents are thus desperately needed in medicine.Recently, researchers have demonstrated that Ag formulations also have potential as antibiofilm agents; these formulations include silver sulfadiazine (AgSD) (24), Ag nanoparticles (AgNPs) (25, 26), and silver nitrate (AgNO 3 ) (27). Currently, the wound care industry is replete with Ag-based ointments and wound dressings with claimed efficacy at reducing bacterial bioburden (7,(28)(29)(30)(31)(32). However, only a few antibiofilm products exist. There are numerous reasons why this is so: (i) current standardized, antimicrobial testing methods focus on bacteria in their planktonic state and not as biofilms (33, 34); (ii) biofilms are characteristically more tolerant to metal poisoning (35-38); and (iii) the detailed mechanism of action for the toxicity of Ag to biofilms remains to be fully described (1).The antimicrobial activity of Ag is intrinsically dependent on the formation of the Ag 1ϩ ion (7, 39). Briefly, Ag 1ϩ , a Lewis soft acid, poisons the microbial cell by binding to reduced thiols (SH), impairing membrane function (1), and disrupting ironsulfur clusters (40). That being said, the antimicrobial efficacy of higher oxidation states of Ag, Ag 2ϩ and Ag 3ϩ , has not been given adequate consideration, mainly due to instability in solution. A promising resolution to the instability of higher oxidation states of Ag is silver oxysalts, for example, Ag(Ag 3 O 4 ) 2 X, the most stable of which is coordina...

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“…Hence, silver has been incorporated into a wide variety of wound dressings consisting of collagen [92,93] , bacterial cellulose [94] , or alginate. [70,95] By incorporating silver into alginate fibers, a highly absorbent wound dressing with antimicrobial properties is obtained. [70] In order to attach silver ions, calcium alginate fibers can be treated with aqueous solutions of silver nitrate.…”

Section: Collagenmentioning

confidence: 99%

Polymer‐based Biomaterials as Dressings for Chronic Stagnating Wounds

Wiegand¹,

Hipler²

2010

Macromolecular Symposia

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Summary: Chronic wounds, such as venous, pressure, and diabetic ulcers, are difficult to heal and represent a rising social and economical problem. Compared to acute wounds, non-healing wounds contain elevated levels of neutrophil elastase, proinflammatory cytokines (IL-1b, IL-6, IL-8), and matrix metalloproteases (MMP-2, MMP-9, MMP-13) as well as free radicals. Their overproduction perpetuates the inflammatory phase resulting in severe tissue damage and degradation of growth factors. Consequently, wound closure is prevented and the wound remains non-healing for month or even years. The increasing numbers of patients suffering from wounds that fail to heal are a significant challenge for health care professionals. Wound dressings play an important role in the entire management of these wounds. New materials and treatment strategies are needed to improve wound care. Recent advances in the field of biomaterials and their medical applications indicate the significance and potential of various natural polymers in the development of novel classes of wound dressings. Native polymers are an ideal source for bio-active wound dressings because of their availability and biocompatibility. Hence, several studies have been conducted to explore the influence of wound dressings consisting of collagen, oxidized regenerated cellulose, bacterial cellulose, chitosan, or alginate on the destructive milieu in chronic wounds.

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Nanocrystalline silver dressings as an efficient anti-MRSA barrier: a new solution to an increasing problem

Cited by 69 publications

References 14 publications

In Vitro Evaluation of the Antimicrobial Effectiveness and Moisture Binding Properties of Wound Dressings

In Vitro Evaluation of the Antimicrobial Effectiveness and Moisture Binding Properties of Wound Dressings

Silver Oxynitrate, an Unexplored Silver Compound with Antimicrobial and Antibiofilm Activity

Polymer‐based Biomaterials as Dressings for Chronic Stagnating Wounds

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