Nanocrystalline hydroxyapatite in regeneration of periodontal intrabony defects: A systematic review and meta-analysis

Shaikh, Muhammad Saad; Zafar, Muhammad Sohail; Alnazzawi, Ahmad; Javed, Fawad

doi:10.1016/j.aanat.2021.151877

Cited by 15 publications

(6 citation statements)

References 79 publications

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“…There is significant evidence that using bioactive glasses in conjunction with or instead of other biomaterials has great potential to treat periodontal infrabony, furcation, and gingival recession defects. Barrier membranes [53], enamel matrix derivatives (EMDs) [54][55][56], various bone grafts [57][58][59], and growth factors [60,61] have been used to treat periodontal hard and soft tissue problems utilizing bioactive glass.…”

Section: Bioactive Glass In Clinical Applications Of Periodontal Dise...mentioning

confidence: 99%

Bioactive Glass Applications in Different Periodontal Lesions: A Narrative Review

2023

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Tissue engineering in the orofacial region with bioactive components by the activation of immune complexes or other proteins is the current focus of biomaterials research. Consequently, natural ground materials and tissue components are being created. Bioactive glass is one of the most promising biomaterials and has bioactive properties making it suited for a range of different clinical dental applications, including the regeneration of hard tissues in the craniofacial region. This narrative review provides a summary of the favorable properties and recent applications of bioactive glass materials for the management of periodontal lesions. Bioactive glass mimics natural calcified tissues in terms of composition and has a bioactive role in bone regeneration. The present review concluded that bioactive glass materials have a promising potential for various periodontal applications including the repair of infrabony defects, gingival recession, furcation defects, and guided tissue regeneration. However, further in vivo studies and clinical trials are warranted to advance and validate the potential of bioactive glass for periodontal applications and translate its usage in dental clinics for periodontology.

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Section: Bioactive Glass In Clinical Applications Of Periodontal Dise...mentioning

confidence: 99%

Bioactive Glass Applications in Different Periodontal Lesions: A Narrative Review

2023

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“…Research is being carried out in the field of bone regeneration for periodontal defects. Guided tissue regeneration (GTR) procedures [ 52 , 53 , 54 ], the use of enamel matrix derivatives (EMD) [ 55 , 56 , 57 , 58 ], growth factors (GF) [ 59 , 60 , 61 ], BMPs [ 62 ], platelet-rich plasma/fibrin (PRP/PRF) [ 63 , 64 , 65 ], and various bone grafting procedures [ 66 , 67 , 68 , 69 ] have been extensively described in the literature. Autogenous material obtained from the same individual is always considered the gold standard because of its high osteogenic, osteoinductive, and osteoconductive potential [ 70 ].…”

Section: Clinical Applications Of Auto-bgmentioning

confidence: 99%

Autogenous Tooth Bone Grafts for Repair and Regeneration of Maxillofacial Defects: A Narrative Review

Janjua

Qureshi

Shaikh

et al. 2022

IJERPH

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Autogenous tooth graft is an innovative and ingenious technique that employs a stepwise approach and utilizes human teeth as an autogenous source of bone graft. The structure of teeth closely resembles bone, both physically and biochemically, and can be efficiently used for the process as it depicts properties of osteoinduction and osteoconduction. Autogenous tooth bone has characteristics similar to bone grafts in terms of healing potential, physical properties, and clinical outcome. Autogenous tooth graft has shown reasonable promise as a graft material for the regeneration of maxillary and mandibular defects. Autogenous tooth bone graft finds its principal application in sinus and ridge augmentations and for socket preservation before implant placement. Additionally, it can be used successfully for alveolar cleft patients and patients with limited periodontal defects. The overall complication rates reported for autogenous tooth grafts are comparable to other graft sources. However, although long-term results are still underway, it is still recommended as a grafting option for limited defects in the cranio-facial region.

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“…The loss of supporting AB surrounding a tooth causes tooth mobility and displacement, ultimately leading to tooth loss [ 1 ]. Numerous approaches, such as BRGs [ 5 , 6 , 7 , 8 , 139 ], scaffolds [ 140 ], stem cells [ 141 ], and growth factors [ 9 , 10 ], have been developed to improve the osteogenesis process. BRGs are usually classified into four types [ 93 , 142 ].…”

Section: Regenerative Mechanisms Of Periodontal Tissuesmentioning

confidence: 99%

“…While traditional periodontal and/or surgical therapies are typically effective in limiting disease development, they cannot repair destroyed periodontal tissue or restore its functioning. Despite the use of different regenerative treatments, such as guided tissue regeneration therapy (GTR) [ 3 , 4 ], bone replacement grafts (BRGs) [ 5 , 6 , 7 , 8 ], multiple growth factor-based treatment [ 9 , 10 ], and enamel matrix derivative [ 11 , 12 , 13 ], the results are sometimes disappointing, with poor clinical predictability.…”

Section: Introductionmentioning

confidence: 99%

Human Umbilical Cord Mesenchymal Stem Cells: Current Literature and Role in Periodontal Regeneration

Shaikh

Shahzad

Tash

et al. 2022

Cells

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Periodontal disease can cause irreversible damage to tooth-supporting tissues such as the root cementum, periodontal ligament, and alveolar bone, eventually leading to tooth loss. While standard periodontal treatments are usually helpful in reducing disease progression, they cannot repair or replace lost periodontal tissue. Periodontal regeneration has been demonstrated to be beneficial in treating intraosseous and furcation defects to varied degrees. Cell-based treatment for periodontal regeneration will become more efficient and predictable as tissue engineering and progenitor cell biology advance, surpassing the limitations of present therapeutic techniques. Stem cells are undifferentiated cells with the ability to self-renew and differentiate into several cell types when stimulated. Mesenchymal stem cells (MSCs) have been tested for periodontal regeneration in vitro and in humans, with promising results. Human umbilical cord mesenchymal stem cells (UC-MSCs) possess a great regenerative and therapeutic potential. Their added benefits comprise ease of collection, endless source of stem cells, less immunorejection, and affordability. Further, their collection does not include the concerns associated with human embryonic stem cells. The purpose of this review is to address the most recent findings about periodontal regenerative mechanisms, different stem cells accessible for periodontal regeneration, and UC-MSCs and their involvement in periodontal regeneration.

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Nanocrystalline hydroxyapatite in regeneration of periodontal intrabony defects: A systematic review and meta-analysis

Cited by 15 publications

References 79 publications

Bioactive Glass Applications in Different Periodontal Lesions: A Narrative Review

Bioactive Glass Applications in Different Periodontal Lesions: A Narrative Review

Autogenous Tooth Bone Grafts for Repair and Regeneration of Maxillofacial Defects: A Narrative Review

Human Umbilical Cord Mesenchymal Stem Cells: Current Literature and Role in Periodontal Regeneration

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