Nanocrystalline diamond containing hydrogels and coatings for acceleration of osteogenesis

Иванова, Л.; Popov, C.; Kolev, Iliyan; Shivachev, Boris; Karadjov, J.; Tarassov, Mihail; Kulisch, W.; Reithmaier, Johann Peter; Apostolova, Margarita D.

doi:10.1016/j.diamond.2010.11.020

Cited by 17 publications

(12 citation statements)

References 25 publications

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“…We have reported results confirming this observation (Ivanova et al, 2011). All data obtained by us indicated that not only the PLGA-PEG-PLGA scaffolds are biocompatible with the EPCs as reported (Trajkovski et al, 2009;Ivanova et al, 2011), but composites with NCDs actually promote their growth and transformation. The processes of EPCs differentiation can influence the expression of several important genes.…”

Section: Wwwintechopencomsupporting

confidence: 82%

“…It has also been suggested that FN plays a unique role during the differentiation of osteoblast cultures connected with the formation of mineralized nodules in vitro (Robey, 1996). We have reported results confirming this observation (Ivanova et al, 2011). All data obtained by us indicated that not only the PLGA-PEG-PLGA scaffolds are biocompatible with the EPCs as reported (Trajkovski et al, 2009;Ivanova et al, 2011), but composites with NCDs actually promote their growth and transformation.…”

Section: Wwwintechopencomsupporting

confidence: 82%

“…Cells with distinct rounded nuclei were observed throughout the scaffold, further suggesting normal cell growth on these composites. The results about EPCs adhesion on PLGA-PEG-PLGA scaffolds can found in (Trajkovski et al, 2009;Ivanova et al, 2011). Fig.…”

Section: Scaffold Colonization and Seeding Efficiencymentioning

confidence: 96%

“…Shock-wave synthesis was used to produce nanocrystalline diamonds (NCDs) by explosive conversion of a trinitrotoluene/hexogene mixture with negative oxygen balance (Ivanova et al, 2011). A water-cooled combustion chamber with 3.0 m 3 volume was applied.…”

Section: Nanocrystalline Diamonds Production and Characterizationmentioning

confidence: 99%

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Osteoporosis: A Look at the Future

Kolev¹,

Иванова²,

Markova³

et al. 2012

Osteoporosis

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Section: Wwwintechopencomsupporting

confidence: 82%

Section: Wwwintechopencomsupporting

confidence: 82%

Section: Scaffold Colonization and Seeding Efficiencymentioning

confidence: 96%

Section: Nanocrystalline Diamonds Production and Characterizationmentioning

confidence: 99%

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Osteoporosis: A Look at the Future

Kolev¹,

Иванова²,

Markova³

et al. 2012

Osteoporosis

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“…Studies show that diamond films on titanium implants alloys exhibit high adhesion and low coefficient of friction, increase wear resistance and allow the implant osteogenesis due to the high chemical stability and biocompatibility, linked to high resistance to bacterial colonization and bioactivity at molecular level (Ivanova et al 2011, Yang et al 2009.…”

mentioning

confidence: 99%

A Novel Porous Diamond - Titanium Biomaterial: Structure, Microstructure, Physico-Mechanical Properties and Biocompatibility

Guimarães

DaMatta

Guimarães

et al. 2017

An. Acad. Bras. Ciênc.

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With the aim of introducing permanent prostheses with main properties equivalent to cortical human bone, Ti-diamond composites were processed through powder metallurgy. Grade 1 titanium and mixtures of Ti powder with 2%, 5% and 10 wt% diamond were compacted at 100MPa, and then sintered at 1250°C/2hr/10 -6 mbar. Sintered samples were studied in the point of view of their microstructures, structures, yield strength and elastic modulus. The results showed that the best addition of diamonds was 2 wt%, which led to a uniform porosity, yield strength of 370MPa and elastic modulus of 13.9 GPa. Samples of Ti and Ti-2% diamond were subjected to in vitro cytotoxicity test, using cultures of VERO cells, and it resulted in a biocompatible and nontoxic composite material.

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Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices

et al. 2016

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Although Ultrananocrystalline diamond (UNCD) has been proposed as a coating material for titanium biomedical implants, the biological effects and toxicity of UNCD particles that could eventually detach have not been studied to date. The biokinetics and biological effects of UNCD compared to titanium dioxide (TiO ) nanoparticles was evaluated in vivo using Wistar rats (n = 30) i.p. injected with TiO , UNCD or saline solution. After 6 months, blood, lung, liver, and kidney samples were histologically analyzed. Oxidative damage by membrane lipidperoxidation (thiobarbituric acid reactive substances-TBARS), generation of reactive oxygen species (superoxide anion- O2-), and antioxidant enzymes (superoxide dismutase-SOD, catalase-CAT) was evaluated in lung and liver. Histologic observation showed agglomerates of TiO or UNCD in the parenchyma of the studied organs, though there were fewer UNCD than TiO deposits. In addition, TiO caused areas compatibles with foci of necrosis in the liver and renal hyaline cylinders. Regarding UNCD, no membrane damage (TBARS) or mobilization of enzymatic antioxidants was observed either in lung or liver samples. No variations in O2- generation were observed in lung (Co: 35.1 ± 4.02 vs. UNCD: 48 ± 9.1, p > 0.05). Conversely, TiO exposure caused production of O2- in alveolar macrophages and consumption of catalase (p < 0.05). The studied parameters suggest that UNCD caused neither biochemical nor histological alterations, and therefore may prove useful as a surface coating for biomedical implants. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2408-2415, 2017.

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Nanocrystalline diamond containing hydrogels and coatings for acceleration of osteogenesis

Cited by 17 publications

References 25 publications

Osteoporosis: A Look at the Future

Osteoporosis: A Look at the Future

A Novel Porous Diamond - Titanium Biomaterial: Structure, Microstructure, Physico-Mechanical Properties and Biocompatibility

Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices

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