Nanocrystal Based Drug Delivery System: Conventional and Current Scenario

Thakkar, Shreya; Shah, Viral; Misra, Manju; Kalia, Kiran

doi:10.2174/1872210510666161014122439

Cited by 18 publications

(6 citation statements)

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“…Process parameters and material attribute like the amount of the drug, amount of milling pearls used, milling speed, milling time and temperature must be controlled to obtain particles in the desired size range 28 . Another alternative top-down method was developed by Muller and co-workers, called piston-gap homogenizer, wherein the suspension is passed at high speed through a small orifice and during passage through the orifice collision of crystals results in the particle size reduction 24 , 33 , 34 , 35 . Erosion from the milling pearl, during the milling process, is the major limitation of the method, but in recent years, yttrium stabilization of milling media has ameliorated this problem.…”

Section: Specific Features and Productionmentioning

confidence: 99%

Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Ahire

Thakkar

Darshanwad

et al. 2018

Acta Pharmaceutica Sinica B

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Advancements in in silico techniques of lead molecule selection have resulted in the failure of around 70% of new chemical entities (NCEs). Some of these molecules are getting rejected at final developmental stage resulting in wastage of money and resources. Unfavourable physicochemical properties affect ADME profile of any efficacious and potent molecule, which may ultimately lead to killing of NCE at final stage. Numerous techniques are being explored including nanocrystals for solubility enhancement purposes. Nanocrystals are the most successful and the ones which had a shorter gap between invention and subsequent commercialization of the first marketed product. Several nanocrystal-based products are commercially available and there is a paradigm shift in using approach from simply being solubility enhancement technique to more novel and specific applications. Some other aspects in relation to parenteral nanosuspensions are concentrations of surfactant to be used, scalability and in vivo fate. At present, there exists a wide gap due to poor understanding of these critical factors, which we have tried to address in this review. This review will focus on parenteral nanosuspensions, covering varied aspects especially stabilizers used, GRAS (Generally Recognized as Safe) status of stabilizers, scalability challenges, issues of physical and chemical stability, solidification techniques to combat stability problems and in vivo fate.

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Section: Specific Features and Productionmentioning

confidence: 99%

Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Ahire

Thakkar

Darshanwad

et al. 2018

Acta Pharmaceutica Sinica B

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“…The concept of formation of nanocrystal is extensively evolved for solubility enhancement. Nanocrystal technology improved dissolution rate, high drug loading, improved oral absorption and bioavailability 37 . Commonly used methods for preparation of nanocrystals are nanoprecipitation, milling, homogenization 38 , Spray drying 39 , Nanopure® XP technology 40 and Spray Freezing into Liquid technology 41 .…”

Section: Nanocrystalsmentioning

confidence: 99%

Biomedical Nanomaterials: A Short Insight of Applications

Singh

Bedi

Faruk

2018

J. Drug Delivery Ther.

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Nanotechnology is rapidly expanding area in the field of science that helps us to manipulate matter at the atomic and molecular level thus having varied and new properties with huge potential. It is the study of extremely small particles ranging from 1-1000 nm. This small size imparts the nanoscale devices their applications in medicine and physiology while permitting them to interact with cells and tissues at subcellular level, with bioreceptors on both the surface and inside of cell membrane thus providing a high degree of functional specificity to the systems. Nanodevices in medicine involves applications of nanoparticles, polymeric micelles, dendrimers, nanotubes, inorganic nanoparticles, nanocrystals and quantam dots which are currently under development as well as constitute the major part of longer range research. Improvement in drug solubility, high drug loading capacity, ease of surface modification, increase in blood circulation time, controlled release and highly site-specific targeted delivery are the advantages responsible for such wide applications of these nanomaterials. The applications include drug and gene delivery to specific site, delivery and detection of specific proteins, biological imaging and biosensors, DNA probing, tissue engineering, pathogens and tumor detection. This article has made an attempt to cover the few insights of nanotechnology as an interesting approach and illustrates various nanosystems along with their advantages, applications and well approved commercially available products. Keywords: Polymeric micelles, Dendrimers, Nanotubes, Inorganic nanoparticles, Nanocrystals and Quantam dots

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“…Nanocrystals are particles of pure drug in nano size range stabilized with the aid of little amount of stabilizer. These differ from other nanomaterials in a way that these are composed of active pharmaceutical ingredient contrary to serving as drug carriers by virtue of excipients that is usually the case with micelles, liposomes and polymeric nanoparticles [12] . Some authors have expanded this definition of nanocrystals to include amorphous form of drug as well, and accept both crystalline and amorphous form in its definition [13,14] .…”

Section: Introductionmentioning

confidence: 99%

Nanocrystal based orally disintegrating tablets as a tool to improve dissolution rate of Vortioxetine

Ahire

Thakkar

Borade

et al. 2021

Bulletin of Faculty of Pharmacy, Cairo University

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Major depressive disorder (MDD) or depression is a heterogeneous mental illness which have direct effect on patient's behavior and cognition; causing constant feeling of unhappiness and loss of concern in earlier enjoyed events. Vortioxetine (VOR) is a new atypical serotonergic antidepressant reported for the treatment of major MDD and has its use in various psychological disorders. Despite its therapeutic potential, it has poor water solubility which creates problem in delivery. Nanocrystal based orally disintegrating tablets (ODTs) are proposed to enhance water solubility and dissolution rate of VOR. Nanosuspension was prepared by nanoprecipitation method after optimizing various parameters. The formulated nanosuspension was effectively converted to solid powder by the lyophilization technique with emphasis on parameters like nature/concentration of cryoprotectants. Prepared nanocrystals were characterized for solid state of drug present, morphology and size after re-dispersion. The powders were then subsequently compressed into ODTs and dissolution profiles of the tablets were compared. The dissolution profile of the ODTs prepared from nanocrystals showed superior dissolution profile in comparison to ODTs prepared from untreated drug.

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Nanocrystal Based Drug Delivery System: Conventional and Current Scenario

Cited by 18 publications

References 0 publications

Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Biomedical Nanomaterials: A Short Insight of Applications

Nanocrystal based orally disintegrating tablets as a tool to improve dissolution rate of Vortioxetine

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