Nanocryosurgery and its mechanisms for enhancing freezing efficiency of tumor tissues

Yan, Jiao; Jing, Liu

doi:10.1016/j.nano.2007.11.002

Cited by 62 publications

(31 citation statements)

References 26 publications

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“…Heating magnetic nanoparticles can be conveniently realized with an induction apparatus over a medium frequency range (several hundreds of kHz), and has been investigated to treat tumors [42, 43, 46–50]. Magnetic nanoparticles have also been shown to improve the efficiency of the microwave rewarming process, and augment tumor treatment with cryosurgery [51, 52]. However, the effect of magnetic induction heating (MIH) of SPM nanoparticles in an AC magnetic field on vitrified cryopreservation has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Magnetic induction heating of superparamagnetic nanoparticles during rewarming augments the recovery of hUCM-MSCs cryopreserved by vitrification

Wang

Zhao

Zhang³

et al. 2016

Acta Biomaterialia

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Cryopreservation by vitrification has been recognized as a promising strategy for long-term banking of living cells. However, the difficulty to generate a fast enough heating rate to minimize devitrification and recrystallization-induced intracellular ice formation during rewarming is one of the major obstacles to successful vitrification. We propose to overcome this hurdle by utilizing magnetic induction heating (MIH) of magnetic nanoparticles to enhance rewarming. In this study, superparamagnetic (SPM) Fe3O4 nanoparticles were synthesized by a chemical coprecipitation method. We successfully applied the MIH of Fe3O4 nanoparticles for rewarming human umbilical cord matrix mesenchymal stem cells (hUCM-MSCs) cryopreserved by vitrification. Our results show that extracellular Fe3O4 nanoparticles with MIH may greatly suppress devitrification and/or recrystallization during rewarming and significantly improve the survival of vitrified cells. We further optimized the concentration of Fe3O4 nanoparticles and the current of an alternating current (AC) magnetic field for generating the MIH to maximize cell viability. Our results indicate that MIH in an AC magnetic field with 0.05% (w/v) Fe3O4 nanoparticles significantly facilitates rewarming and improves the cryopreservation outcome of hUCM-MSCs by vitrification. The application of MIH of SPM nanoparticles to achieve rapid and spatially homogeneous heating is a promising strategy for enhanced cryopreservation of stem cells by vitrification.

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Section: Introductionmentioning

confidence: 99%

Magnetic induction heating of superparamagnetic nanoparticles during rewarming augments the recovery of hUCM-MSCs cryopreserved by vitrification

Wang

Zhao

Zhang³

et al. 2016

Acta Biomaterialia

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“…As demonstrated by experiments, 16 micro or nano foreign particles can promote ice nucleation by lowering the interfacial energy. Therefore, the factor f must have an intimate relationship with the interfacial properties, especially m, whose range is from −1 to 1, determined by the structure match between the ice and the foreign body.…”

Section: Particlementioning

confidence: 94%

Characterization of Micro-/Nano-Scale Ice Crystal Formation in Cryo-Biomedical Engineering: A Review

Li¹,

Jing²

2010

Jnl of Comp & Theo Nano

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The micro-and nano-scale freezing has been a focus in many fields of scientific research and engineering practices, especially in those involved with cryobiology physics. Although a series of theoretical models and experimental techniques have been available to tackle the tough issues that associate with the freezing phase change process, the topic to quantify the ice crystal formation and its subsequent effects on the biological materials were not sufficiently addressed at all, especially when facing the newly emerging area of nano-cryobiology technology. Not only the interactions between the ice front and the cell, but also the heat and solute balance during freezing produce impact on the output of a cryosurgery or cryopreservation. There is currently a strong lack of the generalized methods which are indispensable to grasp the physical pictures from micro or nanoscale aspect and thus help achieve an intensive understanding of the mechanisms of cell damage during process of ice crystallization. This review article is dedicated to present an overview on the theoretical and experimental strategies potentially appropriate for quantifying the ice crystal formation in cryobiology area. Attentions will be focused on several major theoretical directions such as the thermodynamic theory, the kinetic theory, and the density functional theory etc., concerning the micro or nano phase change and the ice nucleation activities. Interpretation of the effects of external conditions such as freezing rate, interfacial effect, size effects, electric field and restricted space etc. on the ice growth will be given. Numerical simulation method and experimental techniques will also be outlined. The review does not intend to give an exhaustive knowledge of all the themes, but rather to provide a most basic background for further probing the emerging nano-cryobiology field and thus promote innovation in future research and practices of cryobiology.

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“…Yan和Liu [41] 最早研究了纳米颗粒在降温过程中对生物组织的影响, 评估了聚四氟乙烯(PTFE)、四氧化三铁、铜、金刚石等纳米颗粒后, 发现不同种类、粒图 2 (网络版彩色)细胞冷冻损伤机制的两因素假说示意图 [33] . 对于特定的细胞类型, 存在一个最佳降温速率.…”

Section: 纳米材料提升降温/冷冻效率unclassified

Applying nanotechnology to cryopreservation studies: Status and future

Zhang

Zhao

2019

Chin. Sci. Bull.

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Nanocryosurgery and its mechanisms for enhancing freezing efficiency of tumor tissues

Cited by 62 publications

References 26 publications

Magnetic induction heating of superparamagnetic nanoparticles during rewarming augments the recovery of hUCM-MSCs cryopreserved by vitrification

Magnetic induction heating of superparamagnetic nanoparticles during rewarming augments the recovery of hUCM-MSCs cryopreserved by vitrification

Characterization of Micro-/Nano-Scale Ice Crystal Formation in Cryo-Biomedical Engineering: A Review

Applying nanotechnology to cryopreservation studies: Status and future

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