“…Therefore, many formulation strategies have been developed to overcome the limitations of these drugs [ 6 , 7 , 8 , 9 , 10 ]. Both traditional approaches (e.g., polymorphs, prodrugs, salt formation, and solid dispersions (SDs)) and current nanotechnologies (e.g., solid lipid nanoparticles, nanoprecipitations, and nanoemulsions) have contributed useful techniques and strategies for the development of formulations of poorly water-soluble drugs [ 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Among them, the development of SDs (even in combination with nanotechnology) is still being heavily investigated to improve the drug solubility, dissolution rate and stability of poorly water-soluble drugs [ 24 , 25 , 26 , 27 , 28 ].…”