Nanocomposites with ornidazole—antibacterial and antiadhesive agents against Gram-positive and Gram-negative bacteria

Abstract

Antimicrobial resistance of many microbial species can cause to thousands of deaths worldwide, in this regard new therapeutic strategies have to be invented. To address the question, we have prepared nanocomposites on the basis of pyrogenic silicon dioxide with ornidazole immobilized on the surface (ornidasil) and studied their antimicrobial properties and the therapeutic potential. It has also been shown, that in comparison with pure ornidazole the addition of ornidazole to nanocomposite composition can enhance the antimicrobial spectrum, including Gram-positive and Gram-negative bacteria. The most significant bactericidal effect has been reached after more than 24-h treatment with the nanocomposite. Antiadhesive properties of nanocomposite materials were studied using blood types OO+, AO+, BO+, AB+, the degree of bacterial adhesion was estimated using three indexes: average adhesion index, index of erythrocytes involvement, index of microbial adhesion. The effectiveness of the treatment with the nanocomposites obtained was studied on complicated wounds of various etiologies, in particular the wounds caused by diabetic foot syndrome.

Biocompatible Nanocomposites for Postoperative Adhesion: A State-of-the-Art Review

“…Given adhesion’s role in infectious disease development, it is worth mentioning that antiadhesive nanocomposites can inhibit the adhesion of microorganisms. This can lead to the development of a new generation of anti-microbial nanocomposites for several strains that are resistant to common antibiotics [ 129 ]. Based on the literature, it can be stated that hydrogels and electrospun nanofibers form the main types of antiadhesive nanocomposites [ 130 , 131 , 132 ].…”