Nanocomposites of boronic acid-functionalized magnetic multi-walled carbon nanotubes with flexible branched polymers as a novel desorption/ionization matrix for the capture and direct detection of cis-diol-flavonoid compounds coupled with MALDI-TOF-MS

Carbon-Based Nanoparticles and Their Surface-Modified Counterparts as MALDI Matrices

“…67 Magnetic MWNTs composited with ε-poly-L-lysine and surface-functionalized with phenylboronic acid have been recently synthesized to serve as MALDI matrices for the identification and quantification of flavonoids in onion and apple juice. 35 High intensity with low S/N deprotonated ions [M−H] − in the negative ion mode was observed with the nanocomposite as the matrix, while conventional matrices produced complex spectra with high interference. 35 ■ GRAPHENE While CNTs are cylindrical graphene (Figure 3), a graphene sheet consists of one plane layer of carbon atoms arranged in a hexagonal lattice similar to CNTs (Figure 3C).…”

“…35 High intensity with low S/N deprotonated ions [M−H] − in the negative ion mode was observed with the nanocomposite as the matrix, while conventional matrices produced complex spectra with high interference. 35 ■ GRAPHENE While CNTs are cylindrical graphene (Figure 3), a graphene sheet consists of one plane layer of carbon atoms arranged in a hexagonal lattice similar to CNTs (Figure 3C). 68 The unique arrangement of carbon atoms in graphene allows easy and high travel velocity of electrons without significant scattering, leading to its excellent electrical conductivity and high UV absorption.…”

“…In addition to being used to enrich a sample prior to MS analysis, several pristine and surface-modified nanoparticles, including metal nanoparticles, silicon-based nanoparticles, nanocomposites, and carbon-based nanoparticles, have been evaluated as MALDI matrices. − The strategy of immobilizing conventional matrices on the surface of nanoparticles has shown promising results for the analysis of low molecular weight analytes, such as pharmaceuticals . Among nanoparticles used as MALDI matrices, carbon-based nanoparticles, in particular, have drawn a great deal of attention as they have high thermal stability, excellent UV absorbance in the wavelength range of 250–350 nm, and high laser desorption/ionization efficiency .…”

Comprehensive review of composition distribution and advances in profiling of phenolic compounds in oilseeds

“…Other emerging technique such as boronic acid-functionalized magnetic multi-walled carbon nanotubes coupled with flexible branched polymer nanocomposites applied as matrix for MALDI-TOF-MS analysis were developed by Li et al and the method demonstrated to be efficient for the analysis of flavonoids in foods ( 62 ). An electrochemical sensor constructed with d-Ti 3 C 2 T x /MWCNTs composite material was reported by Liu et al for the detection of luteolin, and the method showed advantages of low detection limit, good selectivity and high sensitivity ( 31 ).…”

Single-Walled Carbon Nanohorns as Boosting Surface for the Analysis of Low-Molecular-Weight Compounds by SALDI-MS

“…In addition, a substrate composed of polyamide and carbon soot nanoparticles was applied to the determination of methadone in urine and residual malachite green on fish skin showing high sensitivity, good reproducibility and a limit of detection lower than 200 pmol [17]. Boronic acid-functionalized magnetic multi-walled carbon nanotubes were also proposed for the analysis of flavonoids in food matrices, obtaining nmol/L detection limits and good recoveries [18].…”