Nanocomposite sponges of sodium alginate/graphene oxide/polyvinyl alcohol as potential wound dressing: In vitro and in vivo evaluation

Ma, Rongxiu; Wang, Yajing; Qi, Houjuan; Shi, Cai; Wei, Guangbiao; Xiao, Li-Ye; Huang, Zhanhua; Liu, Shouxin; Yu, Haipeng; Teng, Chun‐Bo; Liu, Hu; Murugadoss, Vignesh; Zhang, Jiaoxia; Wang, Yonggui; Guo, Zhanhu

doi:10.1016/j.compositesb.2019.03.006

Cited by 274 publications

(102 citation statements)

References 87 publications

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“…Their porous structure provides various advantages including high hemostatic capacity, high swelling capacity, and high water absorption ability with the capacity to offer a moist environment for the wound and protect the wound from microbial infections [ 102 ]. The sponges that have pore sizes ranging between 10 and 100 µm with interconnected structures possessed the ability to promote cell adhesion and proliferation [ 103 ]. Polymeric sponges formulated from materials such as PVA, cellulose, sodium alginate, chitosan, and graphene oxide, demonstrate good antibacterial properties.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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“…The results of these tests show that BC/AG/Cs-Cu composite membranes appear to display excellent antibacterial activity against E. coli and good biocompatibility when compared with the Acticoat®, Askina® and BluRibbon® commercial wound dressings. Novel dressings for skin injury healing contain alginate alone or, much more often, as a component of a multicomponent material, with, e.g., polyvinyl alcohol [13,14,19,20], gelatine [13,20], silk fibroin [15,16], hyaluronic acid [17] or even graphene oxide [21]. These components are added to increase the mechanical properties, hydrophilicity and adhesion of the cells to the scaffolds.…”

Section: Wounds and Skinmentioning

confidence: 99%

Alginate-Based Hydrogels in Regenerative Medicine

Kaczmarek-Pawelska¹

2020

Alginates - Recent Uses of This Natural Polymer

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This chapter presents the following multipotential applications of alginatebased hydrogels in tissue healing and drug delivery. It contains state of the art and summary of the literature reports, which demonstrate that alginate-based hydrogels have a great potential in tissue healing. Sodium alginate (SA) is mainly used in medical devices for healing of wounds, scars, injuries of bones, regeneration of joint cartilage, and scaffold for cell growth and in drug delivery systems (DDSs). The latest literature describes the effects of laboratory tests and in vivo, which confirm the validity of its use as a biomaterial. Alginate biodegradable scaffolds can be a template that provides a suitable substrate for cellular growth while matching the physiochemical properties of the native extracellular matrix (ECM). Matching scaffold stiffness to the surrounding tissue and optimising its rate of degradation ensure that the infiltrating cells remain viable, maintain their desired phenotype and coordinate their response over the entirety of the wound healing process.

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“…[22,23] Various researches have been developed to use hydrogels as flexible sensors, [24][25][26] supercapacitors, [27] lithium batteries, [28] drug release, [29] actuators, [30] etc. However, due to the evaporation of aqueous solution in hydrogels, [31][32][33] the decreased conductivity and mechanical properties of hydrogels make it difficult to apply the hydrogels to flexible electronics. [34,35] Although some hygroscopic salts have been added to hydrogels to minimize this problem, the evaporation has not been prevented.…”

Section: Introductionmentioning

confidence: 99%

Overview of Ionogels in Flexible Electronics

Zhang

Jiang

Dong

et al. 2020

The Chemical Record

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Ionogels have aroused wide interests in the field of flexible electronics. The combination of solid‐state networks and ionic liquids opens up thousands of possibilities for ionogels. The unique structures of ionogels endow them excellent mechanical properties, conductivity and thermal stability to approach the challenge of flexible electronic. A large number of new ionogels have been developed by different methods including the exchange of solution, polymeric ionic liquid and in‐situ reactions in ionic liquids (gelation of low molecular weight gelators, self‐assembly of block polymers, formation of double‐network structure, ionogel nanocomposites and direct polymerization of polymerizable monomers). The aim of this review is to discuss different preparation methods of ionogels and the comparison of their advantages.

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Nanocomposite sponges of sodium alginate/graphene oxide/polyvinyl alcohol as potential wound dressing: In vitro and in vivo evaluation

Cited by 274 publications

References 87 publications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Alginate-Based Hydrogels in Regenerative Medicine

Overview of Ionogels in Flexible Electronics

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