Nanocomposite scaffold with enhanced stability by hydrogen bonds between collagen, polyvinyl pyrrolidone and titanium dioxide

Li, Na; Fan, Xialian; Tang, Keyong; Zheng, Xuejing; Liu, Jie; Wang, Baoshi

doi:10.1016/j.colsurfb.2015.12.005

Cited by 49 publications

(26 citation statements)

References 42 publications

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“…Likewise, polyvinyl pyrrolidone (PVP) is a polymer as one of the constituent in a polymer blend having properties such as colloidal stabilizer and dispersant . PVP when used in composite polymer blends explicitly revealed properties such as hydrogelation nature, considered as a suitable container for biological cues, provides nanoporous structures, cytocompatibility and improved resistance to degradability in body fluids …”

Section: Introductionmentioning

confidence: 99%

“…16 PVP when used in composite polymer blends explicitly revealed properties such as hydrogelation nature, 17 considered as a suitable container for biological cues, 18 provides nanoporous structures, 19 cytocompatibility 20 and improved resistance to degradability in body fluids. 21 This research study utilized HAp, PVA and PVP to fabricate composite scaffolds of different HAp: polymer ratio (50:50, 70:30 and 80:20). The scaffolds were crosslinked using ribose which is non-toxic in nature, unlike glutaraldehyde which has been used as the crosslinker in literature.…”

Section: Introductionmentioning

confidence: 99%

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Development of mechanically compliant 3D composite scaffolds for bone tissue engineering applications

Anandan¹,

Stella

Nambiraj³

et al. 2018

J Biomedical Materials Res

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Cancellous bone region of the human native bone has the potential to bear significant mechanical loads. However, due to the following parameters such as low trabecular volume, more porosity, less thickness and more interconnectivity, cancellous bone is accessible to damage in accidents or when aging. This research led to the effective fabrication and engineering of cancellous region of the bone for its application in reconstruction or filling of bone voids after resection of large tumor mass. Scaffolds containing hydroxyapatite (HAp), polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) (5% polymer and HAp concentrations) at different HAp: polymer composite ratios (50:50, 70:30 and 80:20), were fabricated by freeze–drying method using only water as solvent and ribose as crosslinker for the scaffolds. The fabricated scaffolds were characterized for its mechanical (compressive) strength, chemical properties using FT‐IR and XRD analyses, swelling and degradation studies, confirmation of mineralization process by immersion in simulated body fluid (SBF) for 7, 15 and 30 days, morphological analysis using scanning electron microscopy (SEM), and biocompatibility properties by performing MTT analysis. From the combined interpretation of the above mentioned tests, it was proven that 80:20 ratio of HAp to polymers was found to be the most suitable scaffold in terms of its optimal properties for its use as bone graft material for trabecular bone. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3267–3274, 2018.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of mechanically compliant 3D composite scaffolds for bone tissue engineering applications

Anandan¹,

Stella

Nambiraj³

et al. 2018

J Biomedical Materials Res

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“…The use of naturally made scaffolds is the best approach, but they may lack the physical/mechanical properties needed for the new tissue formed.We have developed a composite biomaterial scaffold made from collagen fibers embedded in alginate hydrogel [12][13][14][15][16][17]. The collagen used as a biopolymer for producing implantable medical devices is usually obtained through chemical extraction and reconstitution processes, resulting in products with poor mechanical strength [18][19][20]. However, the biocomposite we describe here focuses on the unique coral-derived collagen fibers that were recently identified for their molecular composition and structure [13,14] and mechanical properties [12,[15][16][17].…”

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confidence: 99%

Mesenchymal Cell Growth and Differentiation on a New Biocomposite Material: A Promising Model for Regeneration Therapy

Pomeraniec

Benayahu

2020

Biomolecules

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Mesenchymal stem cells serve as the body's reservoir for healing and tissue regeneration. In cases of severe tissue trauma where there is also a need for tissue organization, a scaffold may be of use to support the cells in the damaged tissue. Such a scaffold should be composed of a material that can biomimic the mechanical and biological properties of the target tissues in order to support autologous cell-adhesion, their proliferation, and differentiation. In this study, we developed and assayed a new biocomposite made of unique collagen fibers and alginate hydrogel that was assessed for the ability to support mesenchymal cell-proliferation and differentiation. Analysis over 11 weeks in vitro demonstrated that the scaffold was biocompatible and supports the cells viability and differentiation to produce tissue-like structures or become adipocyte under differentiation medium. When the biocomposite was enriched with nano particles (NPs), mesenchymal cells grew well after uptake of fluorescein isothiocyanate (FITC) labeled NPs, maintained their viability, migrated through the biocomposite, reached, and adhered to the tissue culture dish. These promising findings revealed that the scaffold supports the growth and differentiation of mesenchymal cells that demonstrate their full physiological function with no sign of material toxicity. The cells' functionality performance indicates and suggests that the scaffold is suitable to be developed as a new medical device that has the potential to support regeneration and the production of functional tissue.Biomolecules 2020, 10, 458 2 of 11 new tissue to improves regeneration and healing processes [1,[5][6][7][8][9][10][11]. The use of naturally made scaffolds is the best approach, but they may lack the physical/mechanical properties needed for the new tissue formed.We have developed a composite biomaterial scaffold made from collagen fibers embedded in alginate hydrogel [12][13][14][15][16][17]. The collagen used as a biopolymer for producing implantable medical devices is usually obtained through chemical extraction and reconstitution processes, resulting in products with poor mechanical strength [18][19][20]. However, the biocomposite we describe here focuses on the unique coral-derived collagen fibers that were recently identified for their molecular composition and structure [13,14] and mechanical properties [12,[15][16][17]. These attributes make our biocomposite uniquely suitable for use in a new generation of scaffolds that can be tailored to meet the mechanical properties of various target tissues. The biological and mechanical properties of these collagen fibers facilitate the desired physiological activity, together with the promotion of cell proliferation and differentiation. The collagen fibers are embedded in an alginate hydrogel, a polysaccharide extracted from algae that has already been applied in a wide spectrum of uses such as food, pharmaceutics, and medical device industries [21][22][23][24]. The addition of the collagen fibers reinforces the alginate in ...

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“…For improving the mechanical properties of scaffolds used in skin tissue engineering, the 3D nanocomposites are usually used, which consist of type I collagen and TiO 2 nanoparticle-coated polyvinylpyrrolidone (PVP). In this mixture, the hydrogen bonds between collagen, PVP and TiO 2 nanoparticles play the key role in increasing of tensile strength [104]. Not only Au or TiO 2 nanoparticles can be used for increasing of mechanical strength, but also magnetite nanoparticles (MNPs) increase the mechanical strength (e.g., MNP-seeded hydrogel microfibers with poly(N-isopropylacrylamide)) [162].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Nanostructured Materials for Artificial Tissue Replacements

Pryjmaková

Kaimlová

Hubáček

et al. 2020

IJMS

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This paper review current trends in applications of nanomaterials in tissue engineering. Nanomaterials applicable in this area can be divided into two groups: organic and inorganic. Organic nanomaterials are especially used for the preparation of highly porous scaffolds for cell cultivation and are represented by polymeric nanofibers. Inorganic nanomaterials are implemented as they stand or dispersed in matrices promoting their functional properties while preserving high level of biocompatibility. They are used in various forms (e.g., nano- particles, -tubes and -fibers)—and when forming the composites with organic matrices—are able to enhance many resulting properties (biologic, mechanical, electrical and/or antibacterial). For this reason, this contribution points especially to such type of composite nanomaterials. Basic information on classification, properties and application potential of single nanostructures, as well as complex scaffolds suitable for 3D tissues reconstruction is provided. Examples of practical usage of these structures are demonstrated on cartilage, bone, neural, cardiac and skin tissue regeneration and replacements. Nanomaterials open up new ways of treatments in almost all areas of current tissue regeneration, especially in tissue support or cell proliferation and growth. They significantly promote tissue rebuilding by direct replacement of damaged tissues.

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Nanocomposite scaffold with enhanced stability by hydrogen bonds between collagen, polyvinyl pyrrolidone and titanium dioxide

Cited by 49 publications

References 42 publications

Development of mechanically compliant 3D composite scaffolds for bone tissue engineering applications

Development of mechanically compliant 3D composite scaffolds for bone tissue engineering applications

Mesenchymal Cell Growth and Differentiation on a New Biocomposite Material: A Promising Model for Regeneration Therapy

Nanostructured Materials for Artificial Tissue Replacements

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