Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine

Vashist, Arti; Kaushik, Ajeet; Ghosal, Anujit; Bala, Jyoti; Nikkhah-Moshaie, Roozbeh; Wani, Waseem A.; Manickam, Pandiaraj; Nair, Madhavan

doi:10.3390/gels4030075

Cited by 71 publications

(46 citation statements)

References 88 publications

(99 reference statements)

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“…Previous studies have reported that the mechanical property of hydrogels can be enhanced by incorporating inorganic fillers, owing to the molecular interactions between polymer chains and the surface of inorganic fillers. [13,[34][35][36][37][38][39][40][41] We first hypothesized that the incorporation of mesoporous silica nanoparticles with high surface areas can contribute toward enhancing the cohesion property of the PAM/PDA hydrogels while maintaining their adhesive property. We synthesized mesoporous silica nanoparticles with extra-large mesopores (XL-MSNs) for this purpose.…”

Section: Resultsmentioning

confidence: 99%

Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery

Jung

Kim

Lee

et al. 2020

Adv Funct Materials

165

153

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Transdermal drug delivery patches based on hydrogels are widely used for the transdermal delivery of diverse drugs. However, most hydrogels do not exhibit adequate adhesiveness to skin surface. Herein, tissue adhesive hydrogels consisting of polyacrylamide/polydopamine (PAM/PDA) hydrogels embedded with extra-large pore mesoporous silica nanoparticles (XL-MSNs) are proposed based on the synergy of cohesive and adhesive properties. The incorporation of XL-MSNs leads to enhanced strength and adhesiveness to skin tissue due to an increased cohesive property derived from molecular interactions between XL-MSNs and polymer chains. The application of XL-MSNs to the hydrogel-skin tissue interface leads to a further enhanced adhesiveness due to the adhesive gluing role of XL-MSNs on the interface. The optimized condition enables a 4.9-fold increase in adhesion energy on the porcine skin tissue, compared to the control PAM/PDA patch. Strong adhesion is achieved immediately after the hydrogel patch is attached onto the skin as well as the surfaces of other organs. Finally, transdermal drug delivery through porcine skin is demonstrated by using the hydrogel patch, with a model drug loaded in the XL-MSNs embedded in the patch. These observations indicate a simple but highly effective strategy for preparing a highly adhesive hydrogel patch for transdermal drug delivery.

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Section: Resultsmentioning

confidence: 99%

Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery

Jung

Kim

Lee

et al. 2020

Adv Funct Materials

165

153

View full text Add to dashboard Cite

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“…NC hydrogels have been categorized based on their stimulussensitivity which includes thermo-responsive, light-responsive, electro-responsive, and magnetic-responsive hydrogels. In addition, they have been classified based on their applications, such as in sensors, catalysts, drug delivery systems, wound dressings, and tissue engineering (Song et al, 2015;Vashist et al, 2018). They are also classified according to the type of incorporated nanomaterials, which is the more common type of classification (Sharma et al, 2018;Vashist et al, 2018;Rafieian et al, 2019).…”

Section: Nc Hydrogelsmentioning

confidence: 99%

“…In addition, they have been classified based on their applications, such as in sensors, catalysts, drug delivery systems, wound dressings, and tissue engineering (Song et al, 2015;Vashist et al, 2018). They are also classified according to the type of incorporated nanomaterials, which is the more common type of classification (Sharma et al, 2018;Vashist et al, 2018;Rafieian et al, 2019). Frequently reported nanofillers in NC hydrogels are silica such as nano-clay (Jin et al, 2018) and fumed silica (Kehr et al, 2013), carbon in the form of carbon nanotubes, graphene (Servant et al, 2014) and graphene oxide (GO) (Rasoulzadeh and Namazi, 2017;Tarashi et al, 2019), metal and metal oxide nanoparticles (Tan et al, 2019) such as gold, silver, iron oxide, titanium oxide (TiO 2 ), nanohydroxyapatite, alumina and zirconia, and polymeric nanoparticles such as nano-scaled cellulose (NSC) (Dutta et al, 2019), including cellulose nanofibers, nanocrystals, and nanowhiskers.…”

Section: Nc Hydrogelsmentioning

confidence: 99%

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

et al. 2020

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Since the introduction of tissue engineering as an encouraging method for the repair and regeneration of injured tissue, there have been many attempts by researchers to construct bio-mimetic scaffolds which mimic the native extracellular matrix, with the aim of promoting cell growth, cell proliferation, and restoration of the tissue's native functionality. Among the different materials and methods of scaffold fabrication, one particularly promising class of materials, hydrogels, has been extensively studied, with the inclusion of nano-scaled materials into hydrogels leading to the creation of an exciting new generation of nanocomposites, known as nanocomposite hydrogels. To closely mimic the native tissue behavior, scientists have recently focused on the functionalization of incorporated nanomaterials via chiral biomolecules, with reported results showing great potential. The current article aims to introduce a perspective of nano-scaled cellulose as a promising nanomaterial which can be multi-functionalized for the fabrication of nanocomposite hydrogels with applications in tissue engineering and drug delivery systems. This article also briefly reviews the recently reported literature on nanocomposite hydrogels incorporated with chiral functionalized nanomaterials. Such knowledge paves the path for the development of tailored hydrogels toward practical applications.

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“…Such mechanical features render them quite difficult to handle, or to stabilize after injection in vivo. Therefore, the incorporation of NPs within the scaffold could help solve the mechanical stability issue . Moreover, iron oxide, gold, or carbon‐based NPs render the composite materials responsive to a wide range of external stimuli such as magnetic field, infrared light, or electric field .…”

Section: Introductionmentioning

confidence: 99%

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

Mertz

Harlepp

Goetz

et al. 2019

Advanced Therapeutics

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The blossoming development of nanomaterials and polymer science has opened the way toward new biocompatible scaffolds responding remotely to external stimuli (magnetic field, light, electric field). Such smart scaffolds are envisioned as new implantable tissues displaying multiple therapeutic and imaging functionalities. They hold great promises to achieve a controlled delivery of therapeutics for various diseases, or to ensure a stimuli‐induced cellular response for bone, cardiac, or muscle tissue engineering.

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Nanocomposite Hydrogels: Advances in Nanofillers Used for Nanomedicine

Cited by 71 publications

References 88 publications

Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery

Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

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