Nanocomposite hydrogel to deliver the immunomodulator lenalidomide and anti-inflammatory hesperidin locally to joints affected by rheumatoid arthritis

Du, Xingjie; Lin, Yan; Shuai, Zheyu; Duan, Junfeng; Wang, Changguang; Liu, Junsheng; Jiang, Jun; Wu, Jianming; Zhou, Meiling; Zhang, Zhirong; Liu, Zhongbing; Zhou, Xiangyu; Jing, Pei; Sun, Xiaoduan; Zhong, Zhirong

doi:10.1016/j.cej.2023.146270

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2024

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“…42,44,45 Recent studies have shown that the employment of both polymeric micelles and prodrugs as a combined strategy is gaining momentum as a highly attractive and groudbreaking solution. 46,47 Prodrugs represent inactive precursors of drugs that gain activity or undergo biotransformation upon reaching the target site. 48 With significant progress in biomedical materials, a number of drug-delivering micelles have been developed, capable of specifically targeting tumor sites and delivering chemotherapy drugs.…”

Section: Introductionmentioning

confidence: 99%