Nanocomposite gels of poloxamine and Laponite for β-Lapachone release in anticancer therapy

Câmara, Gabriel Bezerra Motta; Barbosa, Raquel de Melo; García‐Villén, Fátima; Viseras, César; Júnior, Renato Ferreira de Almeida; Machado, Paula Renata Lima; Câmara, Celso A.; Farias, Kléber Juvenal Silva; Moura, Túlio Flávio Accioly de Lima e; Dreiss, Cécile A.

doi:10.1016/j.ejps.2021.105861

Cited by 13 publications

(4 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The initial burst release is reduced in the presence of NS, leading to the prolonged release of both small molecules and protein. The bioactivity of adsorbed therapeutics has also been shown to be maintained following interaction with NS [23][24][25]. The NS discs have been used in composite materials such as hydrogels to aid in localized delivery [26].…”

Section: Introductionmentioning

confidence: 99%

Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel Composites

2022

View full text Add to dashboard Cite

Two-dimensional nanosilicate particles (NS) have shown promise for the prolonged release of small-molecule therapeutics while minimizing burst release. When incorporated in a hydrogel, the high surface area and charge of NS enable electrostatic adsorption and/or intercalation of therapeutics, providing a lever to localize and control release. However, little is known about the physio-chemical interplay between the hydrogel, NS, and encapsulated small molecules. Here, we fabricated polyethylene glycol (PEG)-NS hydrogels for the release of model small molecules such as acridine orange (AO). We then elucidated the effect of NS concentration, NS/AO incubation time, and the ability of NS to freely associate with AO on hydrogel properties and AO release profiles. Overall, NS incorporation increased the hydrogel stiffness and decreased swelling and mesh size. When individual NS particles were embedded within the hydrogel, a 70-fold decrease in AO release was observed compared to PEG-only hydrogels, due to adsorption of AO onto NS surfaces. When NS was pre-incubated and complexed with AO prior to hydrogel encapsulation, a >9000-fold decrease in AO release was observed due to intercalation of AO between NS layers. Similar results were observed for other small molecules. Our results show the potential for use of these nanocomposite hydrogels for the tunable, long-term release of small molecules.

show abstract

Section: Introductionmentioning

confidence: 99%

Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel Composites

2022

View full text Add to dashboard Cite

show abstract

“…Tetronics are broadly used in various applications such as anti‐foaming and wetting agents, thickeners, dispersants, and emulsifiers for diverse industrial drives 29,30 . Tetronics are regularly useful in biomedical domains such as genetic immunization, drug delivery, and membrane biochemistry 31‐36 . Despite of this numerous and potential pharmaceutical applications, there are presently no studies reporting the antibacterial activity of tetronic derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…29,30 Tetronics are regularly useful in biomedical domains such as genetic immunization, drug delivery, and membrane biochemistry. [31][32][33][34][35][36] Despite of this numerous and potential pharmaceutical applications, there are presently no studies reporting the antibacterial activity of tetronic derivatives. Whereas, slight modifications of Tetronic surface have been recently reported.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antimicrobial and anticancer activities of Tetronic 1107 Schiff bases

Alasmary

Kenawy

El‐Deeb

et al. 2022

Polymers for Advanced Techs

View full text Add to dashboard Cite

As a result of the serious issues connected to the bacterial infections, there is an imperious need to improve strong and ecofriendly antimicrobial polymers to overcome the limitations of conventional antimicrobial agents. In this trend, poloxamines (Tetronics) which are X‐shaped poly(ethylene oxide)–poly(propylene oxide) diblocks linked to a focal ethylenediamine group; were successfully modified to produce Tetronic Schiff base for enhancing the biological activities of Tetronic 1107. Modification of tetronic 1107 (T1107) was proceeded throughout chloroacetylation of T1107 followed by amination using p‐phenylenediamine then the latter was treated with different aldehydes to yield Tetronic Schiff bases. Characterization of Tetronic Schiff bases was carried out by 1H‐NMR, Fourier‐transform infrared spectroscopy, X‐ray diffraction, elemental analysis and thermogravimetric analysis (TGA) analyses. The antimicrobial activities of four tested compounds coded (EK1, EK2, EK3, and EK4) were quantified using Microtiter‐assay methods. The obtained data revealed potential antimicrobial activities for tested compounds against all tested microbes with priority against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. Sample coded EK4 exhibited the most effective treatment against P. aeruginosa, Candida albicans, S. aureus and E. Coli with minimal inhibitory concentration values of 6, 16, 12.5, and 1.5 μM, respectively. Furthermore, the safety results confirmed that EK4 and EK1 were the safest treatment with IC50 values of 76.01 and 62.67 μM, respectively. In addition, all tested compounds showed significant anticancer effects against MDA‐MB‐231cell line, while EK3 was effective treatment against A549 cell line with IC50 values of 39.63 μM. Meanwhile, both EK2 and EK4 showed the highest selectivity index (SI) values against MDA‐MB‐231 cell line with values 2.5 and 3.07, respectively. Interestingly, EK4 showed the maximum SI values on A549 and Hep‐G2 cell lines with values 1.62 and 1.52, respectively.

show abstract

“…24,27,28 LAP has attracted extensive research interest in cosmetics and biomedicine due to its easy mass production, low cost, desired purity, and controlled composition. 29–31 Furthermore, LAP has been shown to be degradable, especially under acidic conditions, releasing degraded products such as aqueous silica (Si(OH) 4 ), sodium, magnesium and lithium ions into the solution, and has good biocompatibility. 24…”

Section: Introductionmentioning

confidence: 99%

LAPONITE® nanodisk-based platforms for cancer diagnosis and therapy

Guo

et al. 2022

Mater. Adv.

View full text Add to dashboard Cite

show abstract

Nanocomposite gels of poloxamine and Laponite for β-Lapachone release in anticancer therapy

Cited by 13 publications

References 63 publications

Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel Composites

Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel Composites

Synthesis, antimicrobial and anticancer activities of Tetronic 1107 Schiff bases

LAPONITE® nanodisk-based platforms for cancer diagnosis and therapy

Contact Info

Product

Resources

About