Nanoclays in medicine: a new frontier of an ancient medical practice

Katti, Kalpana S.; Jasuja, Haneesh; Jaswandkar, Sharad V.; Mohanty, Sibanwita; Katti, Dinesh R.

doi:10.1039/d2ma00528j

Cited by 21 publications

(15 citation statements)

References 171 publications

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“…It is well known that the smaller the reinforcement, the greater the prospects of obtaining well-developed materials for structural improvement and overall functional benefits [17]. The growing interest in layered silicates for biomedical applications [18] is due to their distinctive physicochemical properties [19], such as crystalline structure, colloidal particle size and shape, layer charge density, specific surface area, cation exchange, and swelling capacity [20]. Also, in addition to being an abundant and low-cost material, the amount of clay nanoparticles (dispersed phase) required for incorporation into a polymeric matrix (continuous phase) in order to convey significant variations is very low [21].…”

Section: Clay Nanoparticlesmentioning

confidence: 99%

“…Since no isomorphous substitution occurs in the 1:1 clay mineral group, they are electrically neutral and have weak hydrogen bonds and Van der Waals forces, no structural (permanent) charges, generally low cation exchange capacity (CEC), and less biomedical interest when compared to the 2:1 type due to their inability to undergo interlayer swelling in water. However, halloysite (HNT) is an exception, since its hydrated 1:1 kaolinite sheets roll up several times into tubular clay nanomaterials (inside O sheet and outside surface T sheet), enabling attractive features for biomedical applications such as total pore volume and high specific surface area [18].…”

Section: Clay Nanoparticlesmentioning

confidence: 99%

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Clay-Based Nanocomposite Hydrogels for Biomedical Applications: A Review

et al. 2022

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In recent decades, new and improved materials have been developed with a significant interest in three-dimensional (3D) scaffolds that can cope with the diverse needs of the expanding biomedical field and promote the required biological response in multiple applications. Due to their biocompatibility, ability to encapsulate and deliver drugs, and capacity to mimic the extracellular matrix (ECM), typical hydrogels have been extensively investigated in the biomedical and biotechnological fields. The major limitations of hydrogels include poor mechanical integrity and limited cell interaction, restricting their broad applicability. To overcome these limitations, an emerging approach, aimed at the generation of hybrid materials with synergistic effects, is focused on incorporating nanoparticles (NPs) within polymeric gels to achieve nanocomposites with tailored functionality and improved properties. This review focuses on the unique contributions of clay nanoparticles, regarding the recent developments of clay-based nanocomposite hydrogels, with an emphasis on biomedical applications.

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Section: Clay Nanoparticlesmentioning

confidence: 99%

Section: Clay Nanoparticlesmentioning

confidence: 99%

Clay-Based Nanocomposite Hydrogels for Biomedical Applications: A Review

et al. 2022

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“…33,34 Therefore, CMs are considered as promising alternatives to synthetic materials in the field of hemostatic materials. 35,36 Historically, CMs were first used in the military field, owing to their excellent procoagulant activity and other unique features, such as lack of allergens derived from human or animals, stable physical and chemical properties, and easy production and transportation. 13,37 A series of simple CM-based hemostatic products have been approved by the Food and Drug Administration for battlefield first aid in recent decades.…”

Section: Introductionmentioning

confidence: 99%

Progress and future prospects of hemostatic materials based on nanostructured clay minerals

Yang,

Wang,

Yang

et al. 2023

Biomater. Sci.

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“…Thanks to their biocompatibility, nanoclays are widely utilized for biomedical applications. 14 In the case of BNT biocomposite films, there are several studies in the literature. [15][16][17][18][19] In the study of Zakaria et al, 15 20 wt% BNT addition in thermoplastic potato starch increased tensile strength by more than 100%.…”

Section: Introductionmentioning

confidence: 99%

“…The bentonite nanoclay is mostly montmorillonite (MMT)‐based natural reinforcement, 13 which is abundant in nature. Thanks to their biocompatibility, nanoclays are widely utilized for biomedical applications 14 …”

Section: Introductionmentioning

confidence: 99%

Biocompatible organic coating fabrication via polymer/clay nanocomposites: Evaluation of mechanical improvements

Kandemir,

Donmez,

Can

2023

Polymer Composites

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This study focuses on achieving mechanical enhancements in biocompatible organic coatings. A solvent‐based method is employed to produce biocompatible nanocomposites using polyvinylpyrrolidone (PVP) and bentonite nanoclays (BNT) as constituents to achieve this objective. Subsequently, the nanocomposites are spin‐coated onto a glass substrate, resulting in smooth and defect‐free films with a thickness of 5 μm. Through instrumented‐indentation testing, it is observed that BNT reinforcement leads to significant improvements in mechanical properties. Specifically, the addition of 0.5, 1, and 5 wt% of BNT in PVP results in enhancements of 105%, 77%, and 430% in elastic modulus, respectively, while hardness is improved by 166%, 211%, and 448%, respectively. The considerable improvements in the composite modulus cannot be adequately explained by assuming perfect adhesion between the constituents of the composite (as suggested by the Halpin–Tsai model) or by considering the contributions from the interface/network of silicate layers (as proposed by the Modified Halpin–Tsai model). Instead, the significant enhancements in hardness and modulus values are primarily attributed to a notable increase in the BNT volume fraction, ranging from 4 to 9 times, occurring under the Berkovich tip due to the aggregated silicate layers. The findings highlight the role of aggregated silicate layers in enhancing both hardness and modulus and contribute to the development of advanced biocompatible coatings with improved mechanical properties.Highlights Enhanced mechanical properties in biocompatible coatings. Biocompatible nanocomposites of polyvinylpyrrolidone (PVP) and bentonite nanoclays (BNT). Spin‐coated nanocomposite films on glass: smooth, defect‐free, 5 μm thick. BNT reinforcement boosts elastic modulus and hardness of PVP. Aggregated silicate layers under compression drive substantial mechanical improvements.

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Nanoclays in medicine: a new frontier of an ancient medical practice

Abstract: Clays have been used as early as 2500 BC in the human civilization for numerous biomedical applications. Ease of availability, biocompatibility and versatility of these unique charged 2D structures abundantly...

Cited by 21 publications

References 171 publications

Clay-Based Nanocomposite Hydrogels for Biomedical Applications: A Review

Clay-Based Nanocomposite Hydrogels for Biomedical Applications: A Review

Progress and future prospects of hemostatic materials based on nanostructured clay minerals

Biocompatible organic coating fabrication via polymer/clay nanocomposites: Evaluation of mechanical improvements

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