Nanoclay-reinforced HA/alginate scaffolds as cell carriers and SDF-1 delivery-platforms for bone tissue engineering

Erezuma, Itsasne; Lukin, Izeia; Pimenta-Lopes, Carolina; Ventura, Francesc; García-García, Patricia; Reyes, Ricardo; Arnau, Ma Rosa; Delgado, Araceli; Taebnia, Nayere; Kadumudi, Firoz Babu; Dolatshahi‐Pirouz, Alireza; Orive, Gorka

doi:10.1016/j.ijpharm.2022.121895

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…151 Laponite is a disc shape nanoparticle that bears a negative charge on the surface and a positive charge on the edges at pH values lower than 9. 152,153 The formation of laponite-protein electrostatic interactions in laponite containing cardiac dECM-based bioink causes a solid-like characteristic to bioink and enhances its stiffness. In addition to the effect of laponite nano-silicates, it was shown that different concentrations of PEGDA as a crosslinker can modulate the mechanical properties of cardiac dECM from 5 to 15 kPa in healthy tissue to 30–100 kPa in diseased and fibrotic heart tissues to fabricate 3D bioprinted models for tissue modeling or drug screening applications.…”

Section: Engineering and Materials Considerationsmentioning

confidence: 99%

Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling

Kafili,

Kabir,

Jalali Kandeloos

et al. 2023

J Biomater Appl

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Despite the advent of tissue engineering (TE) for the remodeling, restoring, and replacing damaged cardiovascular tissues, the progress is hindered by the optimal mechanical and chemical properties required to induce cardiac tissue-specific cellular behaviors including migration, adhesion, proliferation, and differentiation. Cardiac extracellular matrix (ECM) consists of numerous structural and functional molecules and tissue-specific cells, therefore it plays an important role in stimulating cell proliferation and differentiation, guiding cell migration, and activating regulatory signaling pathways. With the improvement and modification of cell removal methods, decellularized ECM (dECM) preserves biochemical complexity, and bio-inductive properties of the native matrix and improves the process of generating functional tissue. In this review, we first provide an overview of the latest advancements in the utilization of dECM in in vitro model systems for disease and tissue modeling, as well as drug screening. Then, we explore the role of dECM-based biomaterials in cardiovascular regenerative medicine (RM), including both invasive and non-invasive methods. In the next step, we elucidate the engineering and material considerations in the preparation of dECM-based biomaterials, namely various decellularization techniques, dECM sources, modulation, characterizations, and fabrication approaches. Finally, we discuss the limitations and future directions in fabrication of dECM-based biomaterials for cardiovascular modeling, RM, and clinical translation.

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Section: Engineering and Materials Considerationsmentioning

confidence: 99%

Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling

Kafili,

Kabir,

Jalali Kandeloos

et al. 2023

J Biomater Appl

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“…18 The hydrogels added with MMT have been shown to enhance the osteogenic differentiation of mesenchymal stem cells (hMSCs) even in media free of differentiation factors, which may push regenerative therapies to a new level. 19 In addition, MMT is also commonly used as a drug delivery platform because of its electrostatic interactions with other molecules. 20,21 In this context, we used alginate as the base material and synthesized MMT-reinforced alginate hydrogels for loading HM-SA/MMT/HM (SMH).…”

Section: Introductionmentioning

confidence: 99%

Osteoimmunity-regulating nanosilicate-reinforced hydrogels for enhancing osseointegration

Li,

Yang,

Wang

et al. 2023

J. Mater. Chem. B

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Nanomaterial-based drug delivery of immunomodulatory factors for bone and cartilage tissue engineering

Lukin,

Erezuma,

Desimone

et al. 2023

Biomaterials Advances

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Nanoclay-reinforced HA/alginate scaffolds as cell carriers and SDF-1 delivery-platforms for bone tissue engineering

Cited by 7 publications

References 30 publications

Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling

Recent advances in soluble decellularized extracellular matrix for heart tissue engineering and organ modeling

Osteoimmunity-regulating nanosilicate-reinforced hydrogels for enhancing osseointegration

Nanomaterial-based drug delivery of immunomodulatory factors for bone and cartilage tissue engineering

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