2017
DOI: 10.1097/mao.0000000000001439
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NANOCI—Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons

Abstract: Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence sub-optimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible fo… Show more

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Cited by 34 publications
(29 citation statements)
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(30 reference statements)
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“…Cochlear implants can replace the function of hair cells by direct electrical stimulation of primary auditory neurons (spiral ganglion neurons, SGNs) [ 5 , 6 ]. However, the efficacy of cochlear implants is limited by the anatomical gap between the electrode array inserted into the scala tympani and the SGNs situated in the Rosenthal´s canal leading to an unspecific stimulation of relatively large groups of neurons [ 7 , 8 ]. Moreover, the performance of cochlear implants strongly depends on the number of surviving neurons and their functionality, i.e., their excitability [ 3 , 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…Cochlear implants can replace the function of hair cells by direct electrical stimulation of primary auditory neurons (spiral ganglion neurons, SGNs) [ 5 , 6 ]. However, the efficacy of cochlear implants is limited by the anatomical gap between the electrode array inserted into the scala tympani and the SGNs situated in the Rosenthal´s canal leading to an unspecific stimulation of relatively large groups of neurons [ 7 , 8 ]. Moreover, the performance of cochlear implants strongly depends on the number of surviving neurons and their functionality, i.e., their excitability [ 3 , 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…54 It may indicate a potential for BDNF-induced regeneration of dendrites, while protecting the axon against degeneration, what possibly improves the nerve electrode interface of the CI by neurite regeneration. 11,14 The detected doses of MSC-secreted BDNF were much lower than the previously tested exogenous 50 ng/mL but showed a similar effect on the neuronal morphology. This may indicate that a continuous production and availability of low doses of BDNF produced by the MSCs can support the SGN similar to NTF-producing cells in the organ of Corti.…”
Section: Amount and Biological Effect Of Released Bdnfmentioning
confidence: 71%
“…But this regeneration was largely uncontrolled and rarely guided to the electrode. [9][10][11][12][13] In the presence of the alginate-embedded MSCs, the number of regenerated neurites was about six times higher and the length of the regenerated neurites was significantly increased. This effect was shown in several studies for exogenous, recombinant BDNF.…”
Section: Amount and Biological Effect Of Released Bdnfmentioning
confidence: 99%
See 1 more Smart Citation
“…In a recent multinational study, named NANOCI, researchers tried to create a gapless interface between auditory nerve fibers and cochlear implant. They generated a modified nano-cochlear implant electrode array that was inserted into the scala tympani and resulted in a neurotrophin-induced attraction of neurites, which led to lower stimulation thresholds and reduction in required stimulation energy [100].…”
Section: How To Insert These Therapies In the Cochlea?mentioning
confidence: 99%