Nanochemoprevention with therapeutic benefits: An updated review focused on epigallocatechin gallate delivery

Yang, Qiong‐Qiong; Wei, Xinlin; Fang, Yapeng; Gan, Ren‐You; Wang, Min; Ge, Yingying; Zhang, Dan; Cheng, Lizeng; Corke, Harold

doi:10.1080/10408398.2019.1565490

Cited by 42 publications

(20 citation statements)

References 127 publications

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“…Progress in vehicle formulation has allowed polyphenols to be contained in lipid nanocapsules [204,205,206], nanoparticles [206,207], exosomes [208], nanocomposites [209], emulsified formulations [206,210,211] or in gel form [212]. Several reports demonstrate increased bioavailability for encapsulated polyphenols in rodents [213,214]. Another unusual approach is the administration of biologically compatible carbon nanotubes [215] grafted with polyphenols, such as gallic acid [216].…”

Section: Future Strategies For Pharmaceutical Development For Neurmentioning

confidence: 99%

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Renaud

Martinoli

2019

IJMS

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Over the last two decades, the increase in the incidence of neurodegenerative diseases due to the increasingly ageing population has resulted in a major social and economic burden. At present, a large body of literature supports the potential use of functional nutrients, which exhibit potential neuroprotective properties to mitigate these diseases. Among the most studied dietary molecules, polyphenols stand out because of their multiple and often overlapping reported modes of action. However, ambiguity still exists as to the significance of their influence on human health. This review discusses the characteristics and functions of polyphenols that shape their potential therapeutic actions in neurodegenerative diseases while the less-explored gaps in knowledge of these nutrients will also be highlighted.

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Section: Future Strategies For Pharmaceutical Development For Neurmentioning

confidence: 99%

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Renaud

Martinoli

2019

IJMS

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“…In the past decades, NDDS has been extensively explored due to their multiple benefits, such as improving pharmaceutical properties, reducing dosing frequency, and enhancing targeting capability (Zhang & Zhang, 2020 ). Some phytopharmaceuticals, such as epigallocatechin gallate (Yang et al, 2020 ), curcumin (Chen et al, 2020 ), and resveratrol (Arora & Jaglan, 2018 ) have been successfully fabricated into nanoformulations to optimize their physicochemical properties and enhance their efficacies. Similarly, Lut has been encapsulated by nanoparticles (NPs) (Majumdar et al, 2014 ), micelles (Qing et al, 2017 ), liposomes (Huang et al, 2017 ; Wu et al, 2018 ), and nanoemulsions (Shin et al, 2018 ) to improve its bioavailability and efficacy.…”

Section: Introductionmentioning

confidence: 99%

Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment

Wang

Feng

et al. 2021

Drug Delivery

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Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-responsive nanoplatforms to improve the bioactivity of Lut. Folic acid (FA) was employed to decorate the nanoparticles (NPs) to enhance its targeting ability. The size of Lut-loaded ROS-responsive nanoparticles (Lut/Oxi-aCD NPs) and FA-modified Lut/Oxi-aCD NPs (Lut/FA-Oxi-aCD NPs) is 210.5 ± 6.1 and 196.7 ± 1.8 nm, respectively. Both Lut/Oxi-aCD NPs and Lut/FA-Oxi-aCD NPs have high drug loading (14.83 ± 3.50 and 16.37 ± 1.47%, respectively). In vitro cellular assays verified that these NPs could be efficiently internalized by 4T1 cells and the released Lut from NPs could inhibit tumor cells proliferation significantly. Animal experiments demonstrated that Lut/Oxi-aCD NPs, especially Lut/FA-Oxi-aCD NPs obviously accumulated at tumor sites, and inhibited tumor growth $3 times compared to the Lut group. In conclusion, the antitumor efficacy of Lut was dramatically improved by targeting delivery with the ROS-responsive nanoplatforms.

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“…Polyphenol compounds widely found in tea, fruits, and vegetables have been considered to be good antioxidants [ 16 , 17 , 18 ]. Both the scavenging of ROS and metal binding by polyphenols are major mechanisms of their antioxidant activity, especially the metal-binding ability [ 19 , 20 , 21 , 22 , 23 , 24 ]. Tannic acid was found to prevent the Fenton reaction by chelating Fe 2+ [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity

et al. 2021

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Caffeic acid phenethyl ester (CAPE) and its structurally-related caffeic acid (CA), ferulic acid (FA) and ethyl ferulate (EF) are constituents of honeybee propolis that have important pharmacological activities. This study found that CAPE—but not CA, FA, and EF—could effectively prevent cellular DNA damage induced by overloaded iron through decreasing the labile iron pool (LIP) levels in HeLa cells. Interestingly, CAPE was found to be more effective than CA in protecting against plasmid DNA damage induced by Fe(II)–H2O2 or Fe(III)–citrate–ascorbate-H2O2 via the inhibition of hydroxyl radical (•OH) production. We further provided more direct and unequivocal experimental evidences for the formation of inactive CAPE/CA–iron complexes. CAPE was found to have a stronger iron-binding ability and a much higher lipophilicity than CA. Taken together, we propose that the esterification of the carboxylic moiety with phenethyl significantly enhanced the iron-binding ability and lipophilicity of CAPE, which is also responsible for its potent protection against iron-mediated cellular DNA damage. A study on the iron coordination mechanism of such natural polyphenol antioxidants will help to design more effective antioxidants for the treatment and prevention of diseases caused by metal-induced oxidative stress, as well as help to understand the structure–activity relationships of these compounds.

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Nanochemoprevention with therapeutic benefits: An updated review focused on epigallocatechin gallate delivery

Cited by 42 publications

References 127 publications

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment

Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity

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