Nanoceria, the versatile nanoparticles: Promising biomedical applications

Saifi, Mohd Aslam; Seal, Sudipta; Godugu, Chandraiah

doi:10.1016/j.jconrel.2021.08.033

Cited by 79 publications

(82 citation statements)

References 206 publications

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“…The effect of the smaller particle size of ceria (in the range of 3–5 nm) in controlling ROS-induced damages can be seen in many in vitro and in vivo models, which is described in the review paper. 58 The scavenging is also found to be the best at a lower concentration i.e., at 5 μM.…”

Section: Resultsmentioning

confidence: 90%

“…In addition, the size of the spherical nanoparticles is found to influence the scavenging of different types of radicals significantly at the desired biological site, i.e., cochlea. 58 The size distribution of the nanoparticles is measured using ImageJ software from the TEM images and is shown in Figure 3 e. The average particle sizes of the samples were calculated to be 9.03 ± 1, 7.67 ± 1, 5.89 ± 1, and 3.75 ± 1 nm for CeO 2 , PEG-coated CeO 2 , Ce 0.5 Zr 0.5 O 2 , and PEG-coated Ce 0.5 Zr 0.5 O 2 , respectively, which is in good agreement with the results obtained from the SEM ( Figure S3 ) and XRD studies. The presence of PEG during the synthesis process resulted in finer and uniformly sized nanoparticles with a narrow size distribution.…”

Section: Resultsmentioning

confidence: 99%

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Enhanced Antioxidant Ability of PEG-Coated Ce_0.5Zr_0.5O₂-Based Nanofluids for Scavenging Hydroxyl Radicals

Rai

Kanagaraj

2022

ACS Omega

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The antioxidant therapy to preserve residual hearing is relatively recent, and the search for effective antioxidants is still ongoing. Though nanoceria has shown promising radical-scavenging capability, improving its antioxidant ability and the dispersion stability of its nanofluid, which is critical to the desired site, i.e., cochlea, still remains a major challenge. The objective of the present work is to study the radical-scavenging capability of poly(ethylene glycol) (PEG)-coated CeO 2 and Ce 0.5 Zr 0.5 O 2 nanoparticles in water and the biologically relevant fluid (PBS buffer). Nanoparticles in the size range of 4.0–9.0 nm are synthesized using the coprecipitation method and characterized using suitable techniques. The scavenging and dispersion stability of the synthesized nanofluid are analyzed using a UV–vis spectrophotometer. It is found that the addition of PEG during the synthesis process promoted the generation of finer nanoparticles with a narrow size distribution and the doping of zirconium produced a large number of defects in the crystallite structure. The PEG coating over the nanoparticles improved the dispersion stability of nanofluids without affecting their surface reactivity, and it is found to be 94 and 80% in water and PBS, respectively, at 500 μM and 60 min, which is maintained till 90 min. The highest scavenging of hydroxyl radicals by PEG-coated Ce 0.5 Zr 0.5 O 2 is found to be 60%, which is significantly superior to that of CeO 2 . The scavenging capability is found to be increased with the concentration of nanoparticles, showing the best scavenging activity at 190 and 150 μM for PEG-coated CeO 2 and Ce 0.5 Zr 0.5 O 2 , respectively, and the scavenging in water is at par with that of PBS, indicating that these nanoparticles are suitable to be used in sites where a biologically relevant fluid is present, e.g., the cochlea. It is proposed that PEG-coated Ce 0.5 Zr 0.5 O 2 having an average size of ∼ 4 nm can be a potential antioxidant in relevant biomedical applications.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Enhanced Antioxidant Ability of PEG-Coated Ce_0.5Zr_0.5O₂-Based Nanofluids for Scavenging Hydroxyl Radicals

Rai

Kanagaraj

2022

ACS Omega

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“…The above investigations indicated a correlation between the structural defects of ceria nanozymes and their catalytic activity as peroxidase mimics [31,55,[96][97][98][99][100]. The high catalytic activity was found on the CeO 2 nanozymes featured with the high level of the surface Ce 3+ fraction and large surface area.…”

Section: Peroxidase-like Activitymentioning

confidence: 82%

“…The capability of CeO 2 for the reversible switch between redox pair of Ce 3+ /Ce 4+ has been recognized as the critical parameters to enable CeO 2 with various enzyme-like catalytic performance, as shown in Fig. 2 [1][2][3][4][5]55]. Their catalytic performance significantly depends on the morphologies, surface abundance of structural defects as well as the catalytic conditions, such as pH, temperatures, and levels of reactive oxygen species (ROS) in the environments [41-43, 55, 60].…”

Section: Catalytic Behaviors Of Ceo 2 As Nanozymesmentioning

confidence: 99%

“…Nanoceria was seldomly reported as peroxidase mimetics in the early stage of nanozymes. It has been reported that nanoceria with a low level of structural defects of oxygen vacancies delivers poor activity due to its weak affinity for H 2 O 2 as well as poor activation to generate the active oxygen species [55]. Recently, porous nanorods of ceria (PN-CeO 2 ) were demonstrated as a highly active and robust artificial peroxidase mimetics, which was attributed to its large surface area and a high level of oxygen vacancy as structural defect [41].…”

Section: Peroxidase-like Activitymentioning

confidence: 99%

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Insights on catalytic mechanism of CeO2 as multiple nanozymes

Tian

Zhai

et al. 2022

Nano Res.

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CeO 2 with the reversible Ce 3+ /Ce 4+ redox pair exhibits multiple enzyme-like catalytic performance, which has been recognized as a promising nanozyme with potentials for disease diagnosis and treatments. Tailorable surface physicochemical properties of various CeO 2 catalysts with controllable sizes, morphologies, and surface states enable a rich surface chemistry for their interactions with various molecules and species, thus delivering a wide variety of catalytic behaviors under different conditions. Despite the significant progress made in developing CeO 2 -based nanozymes and their explorations for practical applications, their catalytic activity and specificity are still uncompetitive to their counterparts of natural enzymes under physiological environments. With the attempt to provide the insights on the rational design of highly performed CeO 2 nanozymes, this review focuses on the recent explorations on the catalytic mechanisms of CeO 2 with multiple enzyme-like performance. Given the detailed discussion and proposed perspectives, we hope this review can raise more interest and stimulate more efforts on this multi-disciplinary field.

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Length‐Controlled Construction of Ceria Nanowires with Ultrafine Diameter and Stable Morphology for Targeted Acute Lung Injury Therapy

Liu

Shi

et al. 2023

Adv Funct Materials

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The overproduction of reactive oxygen species (ROS) is one of the major reasons for the aggravation of acute lung injury (ALI). Smaller‐sized ceria nanoparticles featured with higher ROS scavenging capability than their bigger‐sized counterparts are potential candidates for ALI therapy. However, smaller‐sized ceria nanoparticles are more easily accumulated in spleen and liver rather than lung. Herein, it is reported that this obstacle can be addressed by constructing ceria into ultrafine nanowires, through which the ultrafine diameter ensures the high ROS scavenging activity and the high aspect ratio promotes the lung targeted accumulation. To demonstrate the feasibility of this conception, a platform is developed to realize length‐controlled ceria nanowires (diameter of ≈1.5 nm) synthesis. These nanowires are PEGylated using a carefully optimized procedure that can preserve their fragile crystal structures. The PEGylated nanowires exhibit higher ROS scavenging capabilities than the ≈3.9 nm sized nanoparticles. Most importantly, lung targeted accumulation can be realized through modulating the length of the nanowires, where the longer nanowires (>100 nm) show much higher lung accumulation. Due to these properties, the longer ceria nanowires can effectively scavenge the overproduced ROS during the progression of ALI, and thereby inhibit the edema and inflammation in the lung tissue.

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Nanoceria, the versatile nanoparticles: Promising biomedical applications

Cited by 79 publications

References 206 publications

Enhanced Antioxidant Ability of PEG-Coated Ce_0.5Zr_0.5O₂-Based Nanofluids for Scavenging Hydroxyl Radicals

Enhanced Antioxidant Ability of PEG-Coated Ce_0.5Zr_0.5O₂-Based Nanofluids for Scavenging Hydroxyl Radicals

Insights on catalytic mechanism of CeO2 as multiple nanozymes

Length‐Controlled Construction of Ceria Nanowires with Ultrafine Diameter and Stable Morphology for Targeted Acute Lung Injury Therapy

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Nanoceria, the versatile nanoparticles: Promising biomedical applications

Cited by 79 publications

References 206 publications

Enhanced Antioxidant Ability of PEG-Coated Ce0.5Zr0.5O2-Based Nanofluids for Scavenging Hydroxyl Radicals

Enhanced Antioxidant Ability of PEG-Coated Ce0.5Zr0.5O2-Based Nanofluids for Scavenging Hydroxyl Radicals

Insights on catalytic mechanism of CeO2 as multiple nanozymes

Length‐Controlled Construction of Ceria Nanowires with Ultrafine Diameter and Stable Morphology for Targeted Acute Lung Injury Therapy

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Product

Resources

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Enhanced Antioxidant Ability of PEG-Coated Ce_0.5Zr_0.5O₂-Based Nanofluids for Scavenging Hydroxyl Radicals

Enhanced Antioxidant Ability of PEG-Coated Ce_0.5Zr_0.5O₂-Based Nanofluids for Scavenging Hydroxyl Radicals