Nanoceria and Its Biomedical Relevance

Kailashiya, Jyotsna; Dash, Debabrata

doi:10.1055/s-0039-1694081

Cited by 6 publications

(10 citation statements)

References 34 publications

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“…This means they can be expressed as needed and automatically degenerate when necessary. However, cerium is not present in the human body, and the mechanism of its movement remains unclear . It is implied that cerium can be successfully ingested by cells in both normal and diseased states via multiple pathways.…”

Section: Future and Perspectivesmentioning

confidence: 99%

“…However, cerium is not present in the human body, and the mechanism of its movement remains unclear. 204 It is implied that cerium can be successfully ingested by cells in both normal and diseased states via multiple pathways. According to recent studies, CeO 2 NMs showed positive effects (such as scavenging ROS) and are considered promising biomedical materials in the majority of in vitro and in vivo analyses.…”

Section: Challenges In Exploration Of Mechanistic Insightmentioning

confidence: 99%

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Nanoceria-Based Artificial Nanozymes: Review of Materials and Applications

Xiao

Zhao

et al. 2022

ACS Appl. Nano Mater.

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Nanozymes are nanomaterial-based enzyme mimics that have dominated recent research because of their remarkable catalytic activity, stability, and low cost. Among them, CeO2 nanomaterials (CeO2 NMs) possess distinct physicochemical properties and inherent catalytic properties mimicking oxidase (OXD), peroxidase (POD), catalase (CAT), superoxide dismutase (SOD), phosphatase, nuclease, and photolyases. The surface valence state, Ce4+/Ce3+ conversion, and oxygen vacancies (OVs) on the surface of CeO2 NMs are closely associated with enzyme-like activities. Surface modification (ions, small molecules, and macromolecular capping) can strongly promote or inhibit their catalytic activities. CeO2 NMs have emerged as attractive materials for biochemical applications including biocatalytic conversion, pollutant destruction, antimicrobial therapies, biosensors, and disease therapies. We summarize here the development history, catalytic mechanisms, and surface modification methods of CeO2 mimetic enzymes and the exploration of their applications as alternatives to natural enzymes in biochemical fields. Further, we outline potential challenges and prospects and hope to provide better guidance for the design and application of these promising artificial enzymes.

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Section: Future and Perspectivesmentioning

confidence: 99%

Section: Challenges In Exploration Of Mechanistic Insightmentioning

confidence: 99%

Nanoceria-Based Artificial Nanozymes: Review of Materials and Applications

Xiao

Zhao

et al. 2022

ACS Appl. Nano Mater.

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“…Some studies demonstrated toxic effects mainly in the form of oxidative stress and inflammation, whereas others indicated either protective, little or no effect 35,36 . Several studies reported that the uptake of CeO 2 NPs could induce oxidative stress and DNA damage, cell apoptosis, aberrant cell signalling, dephosphorylation of several substrates and alterations on the transcriptional and posttranslational levels 37 …”

Section: Introductionmentioning

confidence: 99%

“…35,36 Several studies reported that the uptake of CeO 2 NPs could induce oxidative stress and DNA damage, cell apoptosis, aberrant cell signalling, dephosphorylation of several substrates and alterations on the transcriptional and posttranslational levels. 37 In general, the cytotoxicity of NPs depends on many factors such as the particle size, shape, dose, synthesis method and surface charge. However, when it comes to CeO 2 NPs, the main driver for toxicity was found to be the percentage of surface content of Ce 3+ sites.…”

mentioning

confidence: 99%

The use of cerium oxide nanoparticles in liver disorders: A double‐sided coin?

Attia

Rostom

Mashal

2022

Basic Clin Pharma Tox

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Being recognized as the first antioxidant nanoparticles (NPs) proposed for medicine, cerium oxide NPs (CeO2NPs) have recently gained tremendous attention for their vast biomedical applications. Nevertheless, inconsistent reports of either medical benefits or toxicity have created an atmosphere of uncertainty hindering their clinical utilization. Like other NPs advocated as a promising protective/therapeutic option, CeO2NPs are sometimes questioned as a health threat. As CeO2NPs tend to accumulate in the liver after intravenous injection, liver is known to represent the key tissue to test for their therapeutic/toxicological effects. However, more research evidence is still needed before any conclusions can be elicited about the mechanisms by which CeO2NPs could be harmful or protective/therapeutic to the liver tissue. A proper understanding of such discrepancies is warranted to plan for further modifications to mitigate any side effects. Therefore, in this MiniReview, we tried to demonstrate the two sides of the same coin, CeO2NPs, within the liver context. As well, we highlighted a few promising strategies by which the negatives of CeO2NPs could be diminished while enhancing all the positives.

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“…Cerium oxide is used to assist with the healing of various tissues such as the bones, skin, cardiac, and nerves. Recently, the transfer of drugs and genes by CeO 2 nanoparticles and the use of CeO 2 as treatments for cancer and other diseases has received much attention [7,8].…”

Section: Introductionmentioning

confidence: 99%

A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice

Nemati

Assadollahi

Peluso

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Both antioxidant and prooxidant activities have been previously reported for cerium oxide (CeO2). The aim of this study was to investigate the effects of CeO2 at different doses on changes in kidney tissues and markers in neonatal mice. Methods. We randomly divided 30 pregnant NMRI mice into five groups (n=6 per group)—a control group and four groups treated with intraperitoneal (i.p.) administration of different doses of CeO2 (10, 25, 80, or 250 mg/kg body weight (bw)) on gestation days (GD) 7 and GD14. At the end of the treatment period, we analyzed the kidney tissues and serum samples. The levels of two serum redox markers, malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP), were determined. Data were analyzed using one-way ANOVA and Tukey’s test, and a P value of <0.05 was considered significant. Results. The mean total volumes of the renal corpuscle, glomeruli, and Bowman’s capsule membranes significantly increased, and there was a significant decrease in the mean total volume of Bowman’s space in the high-dose CeO2 group compared to that in the control group. No statistically significant differences existed in the serum levels of MDA and FRAP in the treated and control groups. Conclusion. Our results suggest that high doses of CeO2 impair fetal renal development in pregnant mice, which results in kidney damage. Therefore, CeO2 administration during pregnancy could have dose-dependent adverse effects on the developing kidneys in neonates.

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Nanoceria and Its Biomedical Relevance

Cited by 6 publications

References 34 publications

Nanoceria-Based Artificial Nanozymes: Review of Materials and Applications

Nanoceria-Based Artificial Nanozymes: Review of Materials and Applications

The use of cerium oxide nanoparticles in liver disorders: A double‐sided coin?

A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice

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