Nanocellulose as a Vehicle for Drug Delivery and Efficiency of Anticancer Activity: A Short-Review

Yusefi, Mostafa; Shameli, Kamyar

doi:10.37934/jrnn.1.1.3043

Cited by 13 publications

(6 citation statements)

References 20 publications

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“…15 In addition, nanocellulose was already successfully used in oral, ocular, intratumoural and topical drug delivery. [90][91][92] Ooi et al 93 in 2016 prepared gelatinous hydrogels enforced with nanocellulose addition, acquired through chemical cross-linking. The additive caused a significant improvement in the dynamic mechanical properties and crystallinity of the composite.…”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

Bacterial cellulose: Biopolymer with novel medical applications

Jadczak,

Ochędzan-Siodłak

2023

J Biomater Appl

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Due to the growing importance of green chemistry, the search for alternatives to cellulose has begun, leading to the rediscovery of bacterial cellulose (BC). The material is produced by Gluconacetobacter and Acetobacter bacteria, mainly Komagataeibacter xylinus. It is a pure biopolymer, without lignin or hemicellulose, forming a three-dimensional mesh, showing much lower organization than its plant counterpart. Thanks to its design, it has proven itself in completely unprecedented applications - especially in the field of biomedical sciences. Coming in countless forms, it has found use in applications such as wound dressings, drug delivery systems, or tissue engineering. The review article focuses on discussing the main structural differences between plant and bacterial cellulose, methods of bacterial cellulose synthesis, and the latest trends in BC applications in biomedical sciences.

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Section: Drug Delivery Applicationsmentioning

confidence: 99%

Bacterial cellulose: Biopolymer with novel medical applications

Jadczak,

Ochędzan-Siodłak

2023

J Biomater Appl

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“…Figure 14(b) represents the applications of NCs in drug delivery with examples such as wound dressings and microneedles, which are advanced drug delivery methods. NCs is utilized for several drug delivery systems such as transdermal, oral, ocular, intratumoral, and topical drug delivery [486][487][488]. Ooi et al [489] prepared gelatin hydrogels reinforced with CNC by chemical crosslinking.…”

Section: Application Of Nanocellulose In Drug Deliverymentioning

confidence: 99%

Biomedical engineering aspects of nanocellulose: a review

Rai

Dhar

2022

Nanotechnology

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Cellulose is one of the most abundant renewable biopolymer in nature and is present as major constituent in both plant cell walls as well as synthesized by some microorganisms as extracellular products. In both the systems, cellulose self-assembles into a hierarchical ordered architecture to form micro to nano-fibrillated structures, on basis of which it is classified into various forms. Nanocellulose (NCs) exist as rod-shaped highly crystalline cellulose nanocrystals (CNC) to high aspect ratio cellulose nanofibers (CNF), micro-fibrillated cellulose (MFC) and bacterial cellulose (BC), depending upon the origin, structural and morphological properties. Moreover, NCs have been processed into diversified products ranging from composite films, coatings, hydrogels, aerogels, xerogels, organogels, rheological modifiers, optically active birefringent colored films using traditional-to-advanced manufacturing techniques. With such versatility in structure-property, NCs have profound application in areas of healthcare, packaging, cosmetics, energy, food, electronics, bioremediation, and biomedicine with promising commercial potential. Herein this review, we highlight the recent advancements in synthesis, fabrication, processing of NCs, with strategic chemical modification routes to tailor its properties for targeted biomedical applications. We also study the basic mechanism and models for biosynthesis of cellulose in both plant and microbial systems and understand the structural insights of NC polymorphism. The kinetics study for both enzymatic/chemical modifications of NCs and microbial growth behavior of BC under various reactor configurations are studied. The challenges associated with the commercial aspects as well as industrial scale production of pristine and functionalized NCs to meet the growing demands of market are discussed and prospective strategies to mitigate them are described. Finally, post chemical modification evaluation of biological and inherent properties of NC are important to determine their efficacy for development of various products and technologies directed for biomedical applications.

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“…Nano-sized medicines may favorably enhance circulation time, targeted activities, and safe drug delivery to decrease the issues of side effects from the chemotherapy treatments [ 22 , 23 , 24 ]. For this aim, biopolymer-based NPs may ideally avoid the immune system to increase circulation time of the NPs in blood to enhance the anticancer actions [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

5-Fluorouracil Encapsulated Chitosan-Cellulose Fiber Bionanocomposites: Synthesis, Characterization and In Vitro Analysis towards Colorectal Cancer Cells

et al. 2021

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Cellulose and chitosan with remarkable biocompatibility and sophisticated physiochemical characteristics can be a new dawn to the advanced drug nano-carriers in cancer treatment. This study aims to synthesize layer-by-layer bionanocomposites from chitosan and rice straw cellulose encapsulated 5-Fluorouracil (CS-CF/5FU BNCs) using the ionic gelation method and the sodium tripolyphosphate (TPP) cross-linker. Data from X-ray and Fourier-transform infrared spectroscopy showed successful preparation of CS-CF/5FU BNCs. Based on images of scanning electron microscopy, 48.73 ± 1.52 nm was estimated for an average size of the bionanocomposites as spherical chitosan nanoparticles mostly coated rod-shaped cellulose reinforcement. 5-Fluorouracil indicated an increase in thermal stability after its encapsulation in the bionanocomposites. The drug encapsulation efficiency was found to be 86 ± 2.75%. CS-CF/5FU BNCs triggered higher drug release in a media simulating the colorectal fluid with pH 7.4 (76.82 ± 1.29%) than the gastric fluid with pH 1.2 (42.37 ± 0.43%). In in vitro cytotoxicity assays, cellulose fibers, chitosan nanoparticles and the bionanocomposites indicated biocompatibility towards CCD112 normal cells. Most promisingly, CS-CF/5FU BNCs at 250 µg/mL concentration eliminated 56.42 ± 0.41% of HCT116 cancer cells and only 8.16 ± 2.11% of CCD112 normal cells. Therefore, this study demonstrates that CS-CF/5FU BNCs can be considered as an eco-friendly and innovative nanodrug candidate for potential colorectal cancer treatment.

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Nanocellulose as a Vehicle for Drug Delivery and Efficiency of Anticancer Activity: A Short-Review

Cited by 13 publications

References 20 publications

Bacterial cellulose: Biopolymer with novel medical applications

Bacterial cellulose: Biopolymer with novel medical applications

Biomedical engineering aspects of nanocellulose: a review

5-Fluorouracil Encapsulated Chitosan-Cellulose Fiber Bionanocomposites: Synthesis, Characterization and In Vitro Analysis towards Colorectal Cancer Cells

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