2015
DOI: 10.1016/j.jconrel.2015.07.014
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Nanocarriers with tunable surface properties to unblock bottlenecks in systemic drug and gene delivery

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Cited by 51 publications
(38 citation statements)
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“…19,20 In general, zwitterionic coronas have been shown to improve in vitro stability, cell uptake, and pharmacokinetics of some nano-carriers relative to both PEGylated and unmodified carriers. 21,22 …”
mentioning
confidence: 99%
“…19,20 In general, zwitterionic coronas have been shown to improve in vitro stability, cell uptake, and pharmacokinetics of some nano-carriers relative to both PEGylated and unmodified carriers. 21,22 …”
mentioning
confidence: 99%
“…In order to reach widespread cancer cells, molecular drugs must be specifically directed and protected from natural and tumor-related barriers while in vascular circulation. To this end, over the last few years biomedicine has turned to the use of nanomaterials as smart drug-carriers, although the clinical outcome in treating these diseases is still far from optimal [80][81][82]. In this regard, a large number of biomaterials that are considered to be effective drug-delivery systems on the nanoscale can be found in the literature [83][84][85].…”
Section: Nanoparticle-based Devices For Drug Deliverymentioning
confidence: 99%
“…The surface, size and shape of the nanoparticles are preponderant for their endurance across the circulatory system (reviewed in [40]). Neutral or slightly negative surfaces assure low adsorption to blood proteins, such as opsonins, and avoid phagocytosis (reviewed in [40,41]). Hence, neutralization of charged nanoparticles may be achieved by coating with hydrophilic polymers such as polyethylene glycol (PEG), polyglycerol (PG), or polysaccharides, such as heparan or chitosan, with zwitterionic ligands, such as carboxybetaines or sulfobetaines, with mercaptoalkyl acid ligands, such as 11-mercaptoundecanoic acid (MUA), or even with proteins and lipids (reviewed in [40,42]).…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, for gene therapy it is necessary that the vector and payload pass across the complex hydrophobic layer of the tumor cell membrane [41]. This mainly occurs via endocytosis mediated by ligand-receptor specific, using active targeting, or non-specific, such as electrostatic or hydrophobic, interactions with the cell membrane (reviewed in [40,65,66]).…”
Section: Introductionmentioning
confidence: 99%