Nanocarriers for targeted drug delivery

Controlled Drug Delivery Systems: Current Status and Future Directions

“…The targeted drug delivery system is the system of delivering a drug into the body which is characterised by the transportation of a particular drug selectively at a specified diseased site, to bring pharmacological effects to that particular site and minimize adverse effects on the whole body [ 75 ]. As discussed, a conjugating drug with a biologically compatible polymer would increase the ease of delivery of the drug by increasing the solubility, minimizing the toxic effects of the drug, and optimizing the duration of the drug effect [ 76 ].…”

Paclitaxel-Loaded Folate-Targeted Albumin-Alginate Nanoparticles Crosslinked with Ethylenediamine. Synthesis and In Vitro Characterization

“…More efficiency is pursued with fewer adverse effects, adapting the procedures to the characteristics of each patient. Numerous studies have focused on the development of targeted drug-delivery systems [ 1 ] for cancer treatment in order to reduce side effects due to the unspecific effect of anticancer drugs on healthy cells. Nanocarriers based on natural polymers have the advantage of being a priori biocompatible and also biodegradable.…”

“…Anionic polysaccharides have an important role in the preparation of drug delivery systems [ 4 ]; they have extensively contributed to the development of several types of nanocarriers for cancer treatment and diagnosis. Among anionic polysaccharides, alginate, whose structure is based on a backbone of [ 1 , 2 , 3 , 4 ] linked β-D-mannuronic acid (M units) and α-L-guluronic acid (G units), have been used for preparing different nanocarriers for biomedical applications in the last years [ 5 ]. Alginate has been declared safe by the FDA [ 6 ] for application in humans as a dental impression material or wound dressing, and their hydrogels are the most assayed material for bone tissue engineering and bioprinting since they provide an appropriate niche for cell loading [ 7 ].…”

Paclitaxel-loaded Folate-targeted Albumin-Alginate Nanoparticles Crosslinked with Ethylenediamine. Synthesis and In Vitro Characterization.

“…More efficiency is pursued with fewer adverse effects, adapting the procedures to the characteristics of each patient. Numerous studies have focused on the develop of targeted drug delivery systems [1] for cancer treatment in order to reduce side effects due to the unspecific effect of the anticancer drug on healthy cells. Nanocarriers based on natural polymers have the advantage of being a priori biocompatible and also biodegradable.…”

“…Anionic polysaccharides have an important role in the preparation of drug delivery systems [4], they have extensively contributed to the development of several types of nanocarriers for cancer treatment and diagnosis. Among anionic polysaccharides, alginate, whose structure is based on a backbone of [1][2][3][4] linked β-D-mannuronic acid (M units) and α-L-guluronic acid (G units), have been used for preparing different nanocarriers for biomedical applications in the last years [5]; alginate has been declared safe by FDA [6] for application in humans as dental impression materials or wound dressing, and their hydrogels are the most assayed material for bone tissue engineering and bioprinting since they provide an appropriate niche for cell loading [7]. On the other hand, there is a significant interest in developing anticancer drug carriers based on serum albumin [8] due to the therapeutic efficacy of Abraxane®, an albumin-bound form of paclitaxel, that rapidly dissociate in serum losing some benefits of nanoformulations; some studies have indicated that Abraxane® induced the overexpression of P-glycoprotein and did not allow overcome the common small molecule drug resistance problem mediated by P-gp [9]; in addition, when PTX-loaded albumin nanoparticles crosslinked and non-crosslinked were compared, differences in pharmacokinetics were observed, due to the different physiological way they have of delivering the drug to the tumor [10].…”