Nanocarriers for cancer-targeted drug delivery

Kumari, Preeti; Ghosh, Balaram; Biswas, Swati

doi:10.3109/1061186x.2015.1051049

Cited by 468 publications

(285 citation statements)

References 102 publications

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“…Further advantages related to carrier performance within the physiological environment are the improvement of the therapeutic index, the reduction of the drug toxicity by controlled delivery rate, the improvement of drug's pharmacokinetic profile by enhanced drug stability and minimized systemic clearance and the obtainment of steady state levels (Kumari et al, 2016). More importantly, the site-specificity of the drug release can be achieved by both, passive (e.g.…”

Section: Nanotechnology and Cancer Therapymentioning

confidence: 99%

“…Nanotherapeutics possess unique properties such as high surface area to volume ratio, and controllable physicochemical and biological properties via surface functionalization offering solutions to the current obstacles in cancer therapies and allowing the preparation of multiple drug delivery with synergistic therapeutic response or the combination of therapeutic agents and diagnostic probes into theranostic platforms (Kumari et al, 2016). Further advantages related to carrier performance within the physiological environment are the improvement of the therapeutic index, the reduction of the drug toxicity by controlled delivery rate, the improvement of drug's pharmacokinetic profile by enhanced drug stability and minimized systemic clearance and the obtainment of steady state levels (Kumari et al, 2016).…”

Section: Nanotechnology and Cancer Therapymentioning

confidence: 99%

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Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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Nanotechnology can offer different solutions for enhancing the therapeutic efficiency of polyphenols, a class of natural products widely explored for a potential applicability for the treatment of different diseases including cancer. While possessing interesting anticancer properties, polyphenols suffer from low stability and unfavorable pharmacokinetics, and thus suitable carriers are required when planning a therapeutic protocol. In the present review, an overview of the different strategies based on polymeric materials is presented, with the aim to highlight the strengths and the weaknesses of each approach and offer a platform of ideas for researchers working in the field.

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Section: Nanotechnology and Cancer Therapymentioning

confidence: 99%

Section: Nanotechnology and Cancer Therapymentioning

confidence: 99%

Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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“…Therefore long term use of EPI was limited due to nonspecific toxicity to healthy cells. Mainly due to cardiac toxicity (Kumari et al, 2015).…”

Section: Limitations Of Conventional Chemotherapymentioning

confidence: 99%

Nanotechnology Based Targeted Drug Delivery Systems in Breast Cancer Therapy

Weerathunga¹,

Silva²

2017

International Conference on Bioscience and Biotechnology

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Cancer is a highly heterogeneous and complex disease condition to understand because of its cellular and physiological systems. The most common cancer treatments are chemotherapy, radiotherapy and surgical excision. Out of them chemotherapy remains as the most widely used anti-cancer therapy. But unfortunately chemotherapy has plenty of drawbacks when considering its action on cancerous cells. Many chemotherapeutic drugs are highly toxic, not specific, poorly selective and less soluble because of these incidents cancer patients have severe side effects such as alopecia, renal failures, cardiac failures and etc. In order to overcome these problems in nanotechnology based targeted drug delivery system was introduced. Nanotechnology is a rapidly growing files which promote novel methods in cancer diagnosis, treatments and prognosis. In targeted drug delivery system use differently synthesized nanoparticles to reduce the drawbacks of chemotherapy. Nanoparticles such as liposomes, carbon nanotubes, virus mediated nanoparticles and nanodiamonds are some of the nanoparticles which are being discussed in this article. By using nanoparticles many of the drawbacks in conventional chemotherapy can be altered for an example by using surface functionalized nanoparticles chemotherapeutic drugs can be loaded into the particle and easily can be delivered to the exact tumor site without harming the non-cancerous cells while increasing the halflife of the drug. Likewise there are many advantages in nanotaenology based targeted drug delivery system over the conventional chemotherapy which will give a new ray of hope towards cancer patients to have a quality life.

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“…Next, we administered targeted dox-HSL-containing hydrogels or dox-HSL alone to EF43.fgf-4 tumor-bearing mice and treated the tumors with NIR laser for 3 min at 3.5 W/cm 2 (Fig. 6B).…”

Section: Triggered Heat Generation and Nir-induced Cargo Release In Vmentioning

confidence: 99%

“…These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications. A long-term goal in contemporary cancer nanomedicine has been to design and generate drug delivery systems that improve the narrow therapeutic window associated with conventional chemotherapeutics (1,2). Conceptually, several nanotechnologybased entity candidates, including protocells (3), biosynthetic nanoparticles (NPs), viruses, and liposome-based nanoparticles, could be targeted for active delivery through a defined cell surface ligand receptor system and/or physically triggered for finely tuned cargo release (2,4,5).…”

mentioning

confidence: 99%

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

Hosoya

Dobroff²,

Driessen

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogelbased nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared, thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications. A long-term goal in contemporary cancer nanomedicine has been to design and generate drug delivery systems that improve the narrow therapeutic window associated with conventional chemotherapeutics (1, 2). Conceptually, several nanotechnologybased entity candidates, including protocells (3), biosynthetic nanoparticles (NPs), viruses, and liposome-based nanoparticles, could be targeted for active delivery through a defined cell surface ligand receptor system and/or physically triggered for finely tuned cargo release (2, 4, 5).Numerous efforts have been made to functionalize NPs by combining them with antibodies, aptamers, peptides, vitamins, or carbohydrates (6-8), but the majority of studies involve untargeted nanoplatforms (4, 9). In practice, targeting NPs is far from trivial, and ongoing challenges include synthesis and purification, selection of an appropriate ligand receptor, and specific composition for NP conjugation. Even the conjugation reaction itself may alter the binding of the tumor-targeting moiety to its receptor through conformational changes, steric freedom restriction, or orientation distortion (10, 11). Unfortunately, the SignificanceThe main goal in the emerging field of cancer nanomedicine is to generate, standardize, and produce multifunctional carriers designed to improve the response of drugs against tumors. Here we report the design, development, and preclinical validation of a ligand-directed bioinorganic platform that integrates tumor targeting, receptor-mediated cell internalization, photon-to-heat conversion, and drug delivery. This enabling hydrogel-based technology can accommodate a broad variety of ligands, nanoparticles, and payloads. We show experimental proof-of-concept in mouse models of breast and prostate cancer with molecular imaging and marked reduct...

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Nanocarriers for cancer-targeted drug delivery

Cited by 468 publications

References 102 publications

Polyphenols delivery by polymeric materials: challenges in cancer treatment

Polyphenols delivery by polymeric materials: challenges in cancer treatment

Nanotechnology Based Targeted Drug Delivery Systems in Breast Cancer Therapy

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

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