Nanocarriers as an Emerging Platform for Cancer Therapy

Peer, Dan; Karp, Jeffrey M.; Hong, Seungpyo; Farokhzad, Omid C.; Margalit, Rimona; Langer, Róbert

doi:10.1201/9780429399039-2

Cited by 357 publications

(452 citation statements)

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“…7 However, universally targeting cells within a tumor is not always feasible because some drugs cannot diffuse efficiently and may induce multiple drug resistance—a situation where chemotherapy is failed. 8 Nanotechnology is defined as the introduction, manipulation, and use of materials on the nanometer size scale (1–100 nm). Even though nanoscale materials may be made by the use of variable traditional physical and chemical techniques, it’s presently feasible to biologically synthesize substances through surroundings pleasant green chemistry–based techniques.…”

Section: Introductionmentioning

confidence: 99%

Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats

2019

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Combining chemotherapy with radiotherapy potentiates the outcome of cancer treatment for the more comprehensive attack. In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)induced hepatocellular carcinoma (HCC) in rats. Oral administration of GaNPs (1 mg/Kg b.wt.) 5 times per week for 6 weeks combined with IR to rats treated with DEN (20 mg/Kg b.wt. 5 times per week for 6 weeks) significantly reduced serum levels of alpha-fetoprotein (AFP), aspartate transferase (AST), alanine transferase (ALT), and gammaglutamyltransferase (GGT). In addition, the immunoblotting results of matrix metalloproteinase-9 (MM-9) showed a marked downregulation of protein expression along with a significant decrease in the hepatic level of transforming growth factor b (TGF-b). Furthermore, GaNPs and/or low dose of radiation significantly elevated the level of caspase-3 gene transcript accompanied with evoked DNA fragmentation in rats treated with DEN. The ameliorative effect of GaNPs and IR well appreciated with the histopathological alteration finding in DEN groups. It can be concluded that the combination of GaNPs and/or IR can serve as a good therapeutic agent for the treatment of HCC, which ought to attract more studies.

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Section: Introductionmentioning

confidence: 99%

Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats

2019

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“…Polymeric nanoparticles are commonly used as they have some properties like high structural integrity, stability during storage, and controlled release capability. Polymeric nanoparticles are also easy to prepare and can be used in active targeted delivery easily 12 . Polymeric nanoparticles can be prepared from natural polymers (e.g., Chitosan) and synthetic biodegradable and biocompatible polymers (e.g., poly-lactic-co-glycolic acid (PLGA)).…”

Section: Ijpsr (2021) Volume 12 Issue 1 (Review Article)mentioning

confidence: 99%

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2021

IJPSR

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“…9 Similarly, nanomedicines would orchestrate delivery vehicles, cargos, loading capacities, release kinetics and delivery efficiency. [10][11] Although the significant progressions in biology, informatics and engineering may assist each individual choice in a data-driven manner, the outcomes of the whole conjugates remain hard to predict due to the challenges of translating in vitro hits into in vivo leads. 12 In contrast, a two-step prodrug activation strategy is more versatile.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Non-Covalent Synthesis of a Versatile Platform for Bioorthogonal Prodrugs Activation to Combat Drug Resistance

Yao¹,

Gao²,

Wu³

et al. 2020

Preprint

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Multidrug resistance (MDR) often leads to the failure of the anticancer treatment. Besides the blockage of those MDR pathways, the development of more potent drugs are of urgent needs but largely postponed due to imbalance between safety and efficacy. The prodrug strategy, especially with bioorthogonal activation has shown immerse potential to <a>balance safety and efficacy</a>, while recent studies focus on few drug entities such as doxorubicin and MMAE, leaving the vast collection of toxins undetermined. Here we <a>have enumerate</a>d typical molecular entities ranging from FDA approved drugs (doxorubicin, paclitaxel) to a heated ADC warhead (MMAF-OMe) and a <a>trichothecene</a> toxin (Mytoxin A) to demonstrate that the trans-cyclooctene (TCO) caging may serve as a general prodrug design to increase the therapeutic index for bioactive molecules. These prodrugs can be efficiently activated on-demand by the bioorthogonal activators whose distribution is regulated by the cell specific enzymatic non-covalent synthesis of supramolecular self-assemblies. These cell-specific prodrugs activation could not only reduce the toxicology of drugs but also enhance the synergistic therapeutic effect within a broad range of dose ratio. More importantly, these prodrugs activation share the same activator bearing assemblies, which allows the flexible shift of drug identities to successfully combat MDR cancer in vivo. In general, this versatile bioorthogonal prodrug activation platform is readily applicable to enlarge the therapeutic window for various bioactive molecules. We envision that the spatiotemporal controlled prodrug activation should facilitate the drug discovery and development.

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Nanocarriers as an Emerging Platform for Cancer Therapy

Cited by 357 publications

References 0 publications

Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats

Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats

Untitled

Enzymatic Non-Covalent Synthesis of a Versatile Platform for Bioorthogonal Prodrugs Activation to Combat Drug Resistance

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