“…Our group has designed and synthesized a cationic star polymer (SPc) with low production cost, which can be applied as a nanocarrier/adjuvant of dsRNA/pesticides . For dsRNA delivery, SPc can assemble with dsRNA to avoid enzymatic degradation and promote cellular uptake for efficient gene silencing. , An SPc-based transdermal dsRNA delivery system has been constructed and successfully applied in gene silencing of more than 10 insect species such as soybean aphids, green peach aphids, fruit flies, oriental fruit moths, etc. − For pesticide delivery, the self-assembly of SPc with pesticides can decrease the particle size of pesticides to nanoscale, increase the dispersity and plant uptake of pesticides, and improve their control efficacies against various plant diseases and pests. − For instance, SPc can be used to load thiamethoxam or matrine for nanometerization and improve their plant uptake for enhanced bioactivity against green peach aphids. , The synergistic mechanism may be due to the enhanced delivery of exogenous substances through the SPc-induced activation of the endocytosis pathway in vivo and in vitro . Therefore, SPc shows great potential for field application as an excellent adjuvant.…”