Nanocarrier-mediated transdermal dsRNA-NPF1 delivery system contributes to pest control via inhibiting feeding behavior in Grapholita molesta

Wei, Hongshuang; Tan, Shuqian; Yan, Shuo; Li, Zhen; Shen, Jie

doi:10.1007/s10340-021-01422-y

Cited by 23 publications

(21 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( 4) SPc has been used to construct a transdermal double-stranded RNA (dsRNA) delivery system, and SPc-delivered dsRNA targeting the key genes of insect pests can penetrate the cuticle of pests for efficient gene silencing and pest management. 43,45,59,60 To further improve the control efficacy, SPc can be applied to deliver dsRNA and pesticide simultaneously to meet the actual demands.…”

Section: Contact Angle and Plant Uptake Of The Dinotefuran/spc Complexmentioning

confidence: 99%

A nanocarrier pesticide delivery system with promising benefits in the case of dinotefuran: strikingly enhanced bioactivity and reduced pesticide residue

Jiang

Peng²,

Xie

et al. 2022

Environ. Sci.: Nano

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Contact Angle and Plant Uptake Of The Dinotefuran/spc Complexmentioning

confidence: 99%

A nanocarrier pesticide delivery system with promising benefits in the case of dinotefuran: strikingly enhanced bioactivity and reduced pesticide residue

Jiang

Peng²,

Xie

et al. 2022

Environ. Sci.: Nano

Self Cite

View full text Add to dashboard Cite

show abstract

“…In 2021, a similar nanocarrier-mediated transdermal dsRNA delivery system was developed to control Grapholita molesta, a worldwide fruit-boring pest. 78 Neuropeptide F (NPF) is a crucial molecule that modulates the feeding behavior of insects and presents higher expression in newly hatched larvae than in any other developmental stages, mainly in the midgut. 78 Wei et al 78 observed that a dsRNA/SPc/detergent formulation enhanced the RNAi efficiency against the NPF1 gene, thereby promoting a significant decrease in fruit damage and increasing mortality in newly hatched larvae.…”

Section: Natural Polymersmentioning

confidence: 99%

Micro- and Nanocarriers for Encapsulation of Biological Plant Protection Agents: A Systematic Literature Review

Pinto¹,

Silva²,

Siquenique³

et al. 2022

ACS Agric. Sci. Technol.

View full text Add to dashboard Cite

Biological plant protection agents (BPPAs) are proposed as sustainable alternatives to chemical-based pesticides to face threats caused by pests and diseases emerging due to climate change. The present Review was conducted to identify the most promising materials to encapsulate and deliver BPPAs for pest and disease control with improved efficacy, increased systemic activity, and lower environmental impact. Searches on Scopus and Web of Science databases from inception up to June 30, 2022, revealed a total of 98 reports that met the eligibility criteria, 45% of which described the use of (1) naturally sourced polymers, such as chitosan (36%), alginate (23%) and plant-based proteins (16%); (2) synthetic polymers (35%); (3) inorganic materials (19%); and (4) microorganisms (1%). The review confirmed that micro- and nanoencapsulation of BPPAs using carrier materials of marine/terrestrial/synthetic sources should provide the agricultural community access to safer and more sustainable plant protection products.

show abstract

“…Our group has designed and synthesized a cationic star polymer (SPc) with low production cost, which can be applied as a nanocarrier/adjuvant of dsRNA/pesticides . For dsRNA delivery, SPc can assemble with dsRNA to avoid enzymatic degradation and promote cellular uptake for efficient gene silencing. , An SPc-based transdermal dsRNA delivery system has been constructed and successfully applied in gene silencing of more than 10 insect species such as soybean aphids, green peach aphids, fruit flies, oriental fruit moths, etc. − For pesticide delivery, the self-assembly of SPc with pesticides can decrease the particle size of pesticides to nanoscale, increase the dispersity and plant uptake of pesticides, and improve their control efficacies against various plant diseases and pests. − For instance, SPc can be used to load thiamethoxam or matrine for nanometerization and improve their plant uptake for enhanced bioactivity against green peach aphids. , The synergistic mechanism may be due to the enhanced delivery of exogenous substances through the SPc-induced activation of the endocytosis pathway in vivo and in vitro . Therefore, SPc shows great potential for field application as an excellent adjuvant.…”

Section: Introductionmentioning

confidence: 99%

Biotoxicity Evaluation of a Cationic Star Polymer on a Predatory Ladybird and Cooperative Pest Control by Polymer-Delivered Pesticides and Ladybird

Dong

Chen

Lin

et al. 2022

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Although employing nanocarriers for gene/drug delivery shows great potential in agricultural fields, the biotoxicity of nanocarriers is a major concern for largescale applications. Herein, we synthesized a cationic star polymer (SPc) as a pesticide nanocarrier/adjuvant to evaluate its safety against a widely used predatory ladybird (Harmonia axyridis). The application of SPc at extremely high concentrations nearly did not influence the hatching of ladybird eggs but it led to the death of ladybird larvae at lethal concentration 50 (LC 50 ) values of 43.96 and 19.85 mg/mL through the soaking and feeding methods, respectively. The oral feeding of SPc downregulated many membrane protein genes and lysosome genes significantly, and the cell membrane and nucleus in gut tissues were remarkably damaged by SPc application, revealing that the lethal mechanism might be SPc-mediated membrane damage. Furthermore, the oral feeding of SPc increased the relative abundance of Serratia bacteria in ladybird guts to result in bacterial infection. Coapplication of ladybird and SPc-loaded thiamethoxam/matrine achieved desired control efficacies of more than 80% against green peach aphids, revealing that the coapplication could overcome the slow-acting property of ladybirds. To our knowledge, this is the first attempt to investigate the polymer-mediated lethal mechanism toward natural enemies and explore the possibility of coapplying SPc-loaded pesticides and natural enemies for pest management.

show abstract

Nanocarrier-mediated transdermal dsRNA-NPF1 delivery system contributes to pest control via inhibiting feeding behavior in Grapholita molesta

Cited by 23 publications

References 54 publications

A nanocarrier pesticide delivery system with promising benefits in the case of dinotefuran: strikingly enhanced bioactivity and reduced pesticide residue

A nanocarrier pesticide delivery system with promising benefits in the case of dinotefuran: strikingly enhanced bioactivity and reduced pesticide residue

Micro- and Nanocarriers for Encapsulation of Biological Plant Protection Agents: A Systematic Literature Review

Biotoxicity Evaluation of a Cationic Star Polymer on a Predatory Ladybird and Cooperative Pest Control by Polymer-Delivered Pesticides and Ladybird

Contact Info

Product

Resources

About