Nanocarrier-mediated Delivery of CORM-2 Enhances Anti-allodynic and Anti-hyperalgesic Effects of CORM-2

Joshi, Hari Prasad; Kim, Sung Bum; Kim, Seung Ki; Kumar, Hemant; Jo, Min-Jae; Choi, Hyemin; Kim, Juri; Kyung, Jae Won; Sohn, Seil; Kim, Kyoung‐Tae; Kim, Jin‐Ki; Han, Inbo

doi:10.1007/s12035-019-1468-7

Cited by 19 publications

(31 citation statements)

References 44 publications

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“…61 Other authors have also demonstrated that the administration of CORM-2 loaded in solid lipid nanoparticles (SLNs; CORM-2-SLNs) causes a slow release of carbon monoxide with a half-life 50 times longer than that of CORM-2 and further potentiate the antiallodynic and antihyperalgesic effects of CORM-2 during sciatic nerve injury-induced neuropathic pain. 62 Other CO-RMs that release carbon monoxide under irradiation (PhotoCORMs), including unsaturated cyclic diketones, xanthene carboxylic acids, meso-carboxy BODIPYs, and hydroxyflavone, have also been demonstrated to produce potent anti-inflammatory effects. 63 Another novel class of molecules with potent anti-inflammatory action in models of skin wound, psoriasis, and multiple sclerosis are HYCOs, hybrid compounds consisting of a CO-RM conjugated to a Nrf2/HO-1 activator.…”

Section: T a B L E 1 The Antinociceptive Effects Of Carbon Monoxide Amentioning

confidence: 99%

The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and cannabinoids

Pol

2020

Medicinal Research Reviews

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Chronic pain and its associated comorbidities are difficult to treat, even when the most potent analgesic compounds are used. Thus, research on new strategies to effectively relieve nociceptive and/or emotional disorders accompanying chronic pain is essential. Several studies have demonstrated the anti‐inflammatory and antinociceptive effects of different carbon monoxide‐releasing molecules (CO‐RMs), inducible heme oxygenase 1 (HO‐1), and nuclear factor‐2 erythroid factor‐2 (Nrf2) transcription factor activators in several models of acute and chronic pain caused by inflammation, nerve injury or diabetes. More recently, the antidepressant and/or anxiolytic effects of several Nrf2 transcription factor inducers were demonstrated in a model of chronic neuropathic pain. These effects are mainly produced by inhibition of oxidative stress, inflammation, glial activation, mitogen‐activated protein kinases and/or phosphoinositide 3‐kinase/phospho‐protein kinase B phosphorylation in the peripheral and/or central nervous system. Other studies also demonstrated that the analgesic effects of opioids and cannabinoids are improved when these drugs are coadministered with CO‐RMs, HO‐1 or Nrf2 activators in different preclinical pain models and that these improvements are generally mediated by upregulation or prevention of the downregulation of µ‐opioid receptors, δ‐opioid receptors and/or cannabinoid 2 receptors in the setting of chronic pain. We reviewed all these studies as well as studies on the mechanisms of action underlying the effects of CO‐RMs, HO‐1, and Nrf2 activators in chronic pain. In summary, activation of the Nrf2/HO‐1/carbon monoxide signaling pathway alone and/or in combination with the administration of specific analgesics is a valid strategy for the treatment of chronic pain and some associated emotional disorders.

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Section: T a B L E 1 The Antinociceptive Effects Of Carbon Monoxide Amentioning

confidence: 99%

The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and cannabinoids

Pol

2020

Medicinal Research Reviews

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“…CO releasing compounds are explored for other broad biomedical applications, such as antimicrobial infection, antiallodynic and antihyperalgesia effects …”

Section: Carbon Monoxide Releasing Nanomaterialsmentioning

confidence: 99%

Section: Carbon Monoxide Releasing Nanomaterialsmentioning

confidence: 99%

“…Neuropathic pain is a devastating chronic disease that is characterized by hyperalgesia, allodynia, and unprovoked pain, but the effective treatments are still lacking . An in vivo study using chronic constriction injury (CCI) rat as a disease model demonstrated that both CORM‐2 solution and CORM‐2‐loaded solid lipid nanoparticles (CORM‐2‐SLNs) resulted in reductions in mechanical allodynia and mechanical hyperalgesia . However, CORM‐2‐SLNs conferred a greater ability to prevent mechanical allodynia and mechanical hyperalgesia via significantly decreasing the expression levels of inducible NOS/neuronal NOS and inflammatory factors (TNF‐α, IBA‐1, GFAP) and remarkably increasing expression of HO‐1 and IL‐10.…”

Section: Carbon Monoxide Releasing Nanomaterialsmentioning

confidence: 99%

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Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of gas therapy as it shows the promise of treating various diseases. Due to the gaseous property and the high affinity for human hemoglobin, the main challenges of administrating medicinal CO are the lack of target selectivity as well as the toxic profile at relatively high concentrations. Although abundant CO releasing molecules (CORMs) with the capacity to deliver CO in biological systems have been developed, several disadvantages related to CORMs, including random diffusion, poor solubility, potential toxicity, and lack of on‐demand CO release in deep tissue, still confine their practical use. Recently, the advent of versatile nanomedicine has provided a promising chance for improving the properties of naked CORMs and simultaneously realizing the therapeutic applications of CO. This review presents a brief summarization of the emerging delivery strategies of CO based on nanomaterials for therapeutic application. First, an introduction covering the therapeutic roles of CO and several frequently used CORMs is provided. Then, recent advancements in the synthesis and application of versatile CO releasing nanomaterials are elaborated. Finally, the current challenges and future directions of these important delivery strategies are proposed.

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“…Although CO is well known regarding its toxicity, it has beneficial biological effects in controlled doses and plays a role as a molecular messenger in various physiological processes of the nervous system (28). Various studies indicated that carbon monoxide has anti-inflammatory (29), antiproliferative (30), antiatherogenic (31), antihyperalgesic (32) and antiapoptotic effects (33). CORM-2 molecules are capable of carrying CO to tissues and cells (34).…”

Section: Discussionmentioning

confidence: 99%

The effects of hydrogen sulfide, carbon monoxide and nitric oxide on pentylenetetrazole-induced seizures in rats

Eroğlu

Ünel

Harmanci

et al. 2020

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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Objective: The present study aimed to investigate the anticonvulsant effects of bioactive gas mediator's hydrogen sulfide (H2S), carbon monoxide (CO) and nitric oxide (NO) in pentylenetetrazole (PTZ)-induced convulsions in rats. Material and Methods: Eighty male Wistar-Albino rats randomly divided into ten groups. Convulsions were induced by administering 60 mg/kg PTZ intraperitonally (i.p). Diazepam (1 and 2 mg/kg), sodium hydrosulfide (NaHS, 5 and 10 mg/kg), CO releasing molecule-2 (CORM-2, 5 and 10 mg/kg), L-arginine (LARG, 30 and 100 mg/kg) and L-NG-Nitro arginine methyl ester (L-NAME, 30 mg/kg) were administered 30 minutes after PTZ. Seizure latency, seizure duration and seizure score were evaluated. Data were analyzed by the Kruskal Wallis test followed by posthoc analyses with Tukey. Any p value <0.05 was considered statistically significant. Results: NaHS (10 mg/kg) significantly reduced seizure duration and seizure in comparison with PTZ similar to diazepam (2 mg/kg), but it did not cause any significant change in seizure latency. Other agents did not significantly change seizure latency, seizure duration, and seizure score compared to PTZ. Conclusion: NaHS may be protective in PTZ-induced seizures. More research is needed to investigate the mechanisms underlying this effect.

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Nanocarrier-mediated Delivery of CORM-2 Enhances Anti-allodynic and Anti-hyperalgesic Effects of CORM-2

Cited by 19 publications

References 44 publications

The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and cannabinoids

The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and cannabinoids

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

The effects of hydrogen sulfide, carbon monoxide and nitric oxide on pentylenetetrazole-induced seizures in rats

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