Nanocapsules formation by nano spray drying

Arpagaus, Cordin; John, Philipp; Collenberg, Andreas; Rütti, David

doi:10.1016/b978-0-12-809436-5.00010-0

Cited by 59 publications

(74 citation statements)

References 98 publications

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“…Therefore, based on the literature, we have used a feed suspension, not a feed solution, for spray drying. This technique is referred to as 'nanoenglobing' in the literature [15]. In our study, two different ratios of CEF were used in the formulations (NP-1 & NP-2) for comparison.…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

Öztürk¹,

Aygül²

2020

jrp

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Spray drying is an important method used in pharmaceutical product manufacturing for many years. The nano-spray dryer developed in recent years provides ultrafine powders at nanoscale and high product yields. In this study, which was aimed at prolonged release in oral use, nanoparticles-(NPs) were obtained by nanoenglobation of cefaclor monohydrate-(CEF) with Eudragit RS 100-(ERS) with the help of nano-spray drying method. The particle size (PS) of the blank formulation was 186 nm whereas PSs of CEF containing NPs were between 328 and 389 nm. The average PDI of all NP formulations were below 0.4 and all prepared NPs had a positive ZP value. The encapsulation efficiency values were a range of 78-84 %. In vitro release studies of NPs showed extended-release up to 24 hours after the first 3 hours of burst effect. The results showed that the release kinetics were fitted to the Korsmeyer-Peppas model. As a result, it was found that all pharmaceutical technology analysis results were affected by the solid concentration ratio in the feed dispersion. Antibacterial activity of NP formulations was determined by microdilution method. After minimum inhibitory concentration (MIC) determination, time-dependent activity for NP-2 was investigated by the time-kill method. MIC value for NP-2 was 4-fold lower than MIC value of CEF for Staphylococcus aureus and Escherichia coli. No growth was observed for both bacteria with NP-2 during 18 hours incubation in the time-kill method. As a result, prolonged antibiotic release and long-term antibacterial activity were obtained by NP-2, the optimum formulation of our study.

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Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

Öztürk¹,

Aygül²

2020

jrp

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“…The droplet size depends on the mesh size and the physicochemical properties of the fluid, such as viscosity and surface tension. Spray meshes are available with 4.0, 5.5, and 7.0 µm hole diameters [19]. With a 4.0 µm spray mesh approximately 3 to 8 µm water droplets are produced [12,19,27].…”

Section: Process Parameters Of a Nano Spray Dryermentioning

confidence: 99%

“…During spray drying, the cooling effect of the evaporating solvent keeps the droplet temperature low, so that heat sensitive products like proteins, peptides, hormones, or amino acids can be stabilized Vibrating mesh technology to produce an ultrafine spray in a nano spray dryer (adapted from [19]).…”

Section: Process Parameters Of a Nano Spray Dryermentioning

confidence: 99%

“…Principle of an electrostatic powder collector implemented in the nano spray dryer to extend the size spectrum of separable particles to the nanoscale (adapted from [19]).…”

Section: Figurementioning

confidence: 99%

“…The laboratory-scale nano spray dryer enables the formulation of drugs with solid colloidal particles in the submicron range. Detailed information on the formation of nanocapsules by the nano spray drying technology can be found in several review studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], in particular in a recently published book chapter and review paper by Arpagaus et al [17,19]. The term nanoparticle in the pharmaceutical industry is typically defined as solid colloidal particles with sizes below 1 µm [10,14,23,25,26].…”

Section: Introductionmentioning

confidence: 99%

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Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Arpagaus¹

2018

Int J Med Nano Res

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Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug-containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder particles to the submicron-and nanoscale with very narrow size distributions and sample quantities in the milligram scale at high product yields. This enables the economical use of expensive active pharmaceutical ingredients and pure drugs. The present paper explains the concept of nano spray drying in the laboratory-scale and discusses the influence of the main process parameters on the final powder properties like particle size, morphology, encapsulation efficiency, and drug loading. Application results of nano spray drying for the formulation and encapsulation of different drugs are reviewed.

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Production of Additive‐Free Amorphous Nanoparticles with a SAW‐Based Microfluidic Spray‐Dryer

Steinacher

Gilbert

et al. 2019

Adv Materials Technologies

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Spray‐drying is a widely employed, cost‐effective process to formulate solutions into solid particles of controlled sizes and compositions. In addition, this process can also offer control over the structure of spray‐dried particles: if the solvent is evaporated sufficiently quickly, crystallization of solutes can be kinetically suppressed, resulting in amorphous particles. To achieve the required fast drying of drops and to offer high flexibility in the solvent and solute choice, a surface acoustic wave (SAW)‐based spray‐dryer is introduced that produces drops with diameters of only a few micrometers. These small drops are dried in a dedicated drying unit at room temperature, thereby enabling the fabrication of additive‐free amorphous particles. This device offers an additional advantage: because the formation of drops is decoupled from their drying, chemical reactions can be initiated in drying drops using reactive gases without compromising the robustness of the device operation. This feature is demonstrated on aqueous drops encompassing Ca(OH)2 that are converted into amorphous CaCO3 particles using CO2‐enriched drying air. Because the solvent is evaporated at room temperature, this device offers new possibilities to process heat sensitive samples into powders with well‐defined compositions and unusual structures.

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Nanocapsules formation by nano spray drying

Cited by 59 publications

References 98 publications

Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Production of Additive‐Free Amorphous Nanoparticles with a SAW‐Based Microfluidic Spray‐Dryer

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