Nanobubbles: A Promising Efficient Tool for Therapeutic Delivery

Cavalli, Roberta; Soster, Marco; Argenziano, Monica

doi:10.4155/tde.15.92

Cited by 120 publications

(107 citation statements)

References 142 publications

Supporting

Mentioning

106

Contrasting

Order By: Relevance

“…Graphene is a state-of-the art nanomaterial that consists of a honeycomb 2D lattice in which sp 2 -carbon atoms delocalise the π-electron cloud, the quality of which imparts the material with extraordinary features. 15,16 From a chemical point of view, pristine graphene offers numerous possibilities for noncovalent functionalisation with a variety of molecules, ranging from small drugs 17 to polymeric matrices. 18 In this respect, we demonstrated particularly favourable π-π interactions between melamine (2,4,6-triamino-1,3,5-triazine) and few-layer graphene.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

et al. 2020

View full text Add to dashboard Cite

show abstract

“…15 The smaller size of microbubbles allows extravasation from blood vessels into surrounding tissues, improving stability and giving longer residence times in the systemic circulation. 16 Therefore, lipid-shelled microbubbles might be an appropriate drug delivery system for the combination of a PD1/PD-L1 checkpoint inhibitor and docetaxel (DTX).…”

Section: Introductionmentioning

confidence: 99%

PD-L1-targeted microbubbles loaded with docetaxel produce a synergistic effect for the treatment of lung cancer under ultrasound irradiation

Wang

et al. 2020

Biomater. Sci.

View full text Add to dashboard Cite

Immunotherapy is gradually becoming as important as traditional therapy in the treatment of cancer, but adverse drug reactions limit patient benefits from PD1/PD-L1 checkpoint inhibitor drugs in the treatment of non-small cell lung cancer (NSCLC). As a chemotherapeutic drug for NSCLC, docetaxel (DTX) can synergize with PD1/PD-L1 checkpoint inhibitors but increase haematoxicity and neurotoxicity. Herein, anti-PD-L1 monoclonal antibody (mAb)-conjugated and docetaxel-loaded multifunctional lipid-shelled microbubbles (PDMs), which were designed with biologically safe phospholipids to produce synergistic antitumour effects, reduced the incidence of side effects and promoted therapeutic effects under ultrasound (US) irradiation. The PDMs were prepared by the acoustic-vibration method and then conjugated with an anti-PD-L1 mAb. The material features of the microbubbles and their cytotoxic effects, cellular apoptosis and cell cycle inhibition were studied. A subcutaneous tumour model was established to test the drug concentration-dependent and antitumour effects of the PDMs combined with US irradiation, and an orthotopic lung tumour model simultaneously confirmed the antitumour effect of this synergistic treatment. The PDMs achieved higher cellular uptake than free DTX, especially when combined with US irradiation. The PDMs combined with US irradiation also induced an increased rate of cellular apoptosis and an elevated G2-M arrest rate in cancer cells, which was positively correlated with PD-L1 expression. An in vivo study showed that synergistic treatment had relatively strong effects on tumour growth inhibition, increased survival time and decreased adverse effect rates. Our study possibly provides a well-controlled design for immunotherapy and chemotherapy and has promising potential for clinical application in NSCLC treatment. † Electronic supplementary information (ESI) available: Supplemental results and methods are depicted in the ESI Table S1: Characteristics of different microbubbles. Table S2: Encapsulation efficiency and drug-loading efficiency of microbubbles. Fig. S1: Haemolysis tests of BMs, DMs, and PDMs. Fig. S2: Mouse body weight (A) as well as AST (B), ALT (C), creatinine (D) and blood urea nitrogen (E) levels were monitored over the course of treatment. Fig. S3: HE assessment of the heart, liver, lungs, spleen, and kidneys. Fig. S4: Flow cytometry assay of C6 uptake by LLC cells treated with different formulations. ESI Fig. S5: Flow cytometry analysis of CD4 + and CD8 + TIL numbers after treatments. Fig. S6: LLC cells with Matrigel were injected into the right lung of C57BL/6 mice under X-ray guidance to establish an orthotopic tumour model. See

show abstract

“…Nanobubbles are a type of nanoscale bubbles (1-1,000 nm) with gaseous cores and outer shells. As a ultrasound-responsive material, nanobubbles were designed originally as contrast agents to enhance ultrasound imaging, and developed as drugdelivery carriers later (Cavalli et al, 2016).…”

Section: Novel Ultrasound-responsive Materials Nanobubblesmentioning

confidence: 99%

Ultrasound-Responsive Materials for Drug/Gene Delivery

et al. 2020

View full text Add to dashboard Cite

Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.

show abstract

Nanobubbles: A Promising Efficient Tool for Therapeutic Delivery

Cited by 120 publications

References 142 publications

Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

Stimuli-responsive graphene-based hydrogel driven by disruption of triazine hydrophobic interactions

PD-L1-targeted microbubbles loaded with docetaxel produce a synergistic effect for the treatment of lung cancer under ultrasound irradiation

Ultrasound-Responsive Materials for Drug/Gene Delivery

Contact Info

Product

Resources

About