Nanobiotechnology as an emerging approach to combat malaria: A systematic review

Barabadi, Hamed; Alizadeh, Zahra; Rahimi, Mohammad Taghi; Barać, Aleksandra; Maraolo, Alberto Enrico; Robertson, Lucy J.; Masjedi, Ali; Shahrivar, Firooz; Ahmadpour, Ehsan

doi:10.1016/j.nano.2019.02.017

Cited by 70 publications

(30 citation statements)

References 73 publications

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“…The possibilities of action of metallic NPs extend from attacking the mosquito vector to treating malaria during the human infection cycle. Most metallic NPs explored for these purposes are made of noble metals including silver, gold and palladium, as extensively reviewed in Rahman et al 10 and Barabadi et al 11 In particular, silver has shown good antibacterial properties due to the release of Ag + ions, which likely interact with thiol and phosphate groups in proteins and DNA. This interaction disrupts the cell wall integrity, impairing essential enzymes, inactivating bacterial DNA and RNA or binding subcellular components.…”

Section: Inorganic Npsmentioning

confidence: 99%

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Promising nanomaterials in the fight against malaria

et al. 2020

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Section: Inorganic Npsmentioning

confidence: 99%

“…The antimicrobial activity of metals such as silver, gold or platinum can be enhanced in biosynthesized nanostructured particles, which show up as a potential prevention weapon to hamper malaria transmission. 10,11 Livia Neves Borgheti-Cardoso…”

Section: Introductionmentioning

confidence: 99%

Promising nanomaterials in the fight against malaria

et al. 2020

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“…Notably, different nanoformulations and nanomaterials have been used in practice and the results are promising. In addition, it was strongly claimed that utilizing nanomaterials in either combination or formulation of the conventional drugs not only decreases the probable side effects, but also increases their efficiency (Barabadi et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

In vitro Evaluation of Mannosylated Paromomycin-Loaded Solid Lipid Nanoparticles on Acute Toxoplasmosis

Khosravi

Rahimi

Doroud

et al. 2020

Front. Cell. Infect. Microbiol.

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Toxoplasma gondii is a zoonotic intracellular protozoan with worldwide distribution. Acute and severe toxoplasmosis are commonly reported in patients who suffer from acquired/congenital immune deficiency. This study aimed to synthesize mannosylated paromomycin-loaded solid lipid nanoparticles (PM-SLN-M) and to evaluate them on acute toxoplasmosis. SLN was synthesized and then loaded by 7 mg/mL paromomycin sodium. Mannose coating was performed, and after washing, the size, zeta potential, and loading percentage were calculated. To evaluate the cell toxicity, an MTT assay was performed on Vero cells by different concentrations (log 10 −1) of SLN, PM-SLN-M, and PM-SLN. In addition, the anti-Toxoplasma effects were also evaluated using trypan-blue staining and scanning electron microscopy (SEM). An MTT assay was also employed to evaluate the effects of PM and PM-SLN-M on intracellular Toxoplasma. A 6-month stability test of PM-SLN and PM-SLN-M represented that the characteristics all remained constant. The cell viability assay demonstrated that PM-SLN-M had lower cell toxicity (<20%) compared to PM-SLN (<30%) and PM (<40%). Statistical analysis showed that PM-SLN-M significantly killed ∼97.555 ± 0.629 (95% CI: 91.901 to 103.209; P < 0.05) of T. gondii tachyzoites. More than 50% of Toxoplasma-infected Vero cells remained viable in concentrations more than 0.07 µg/mL and 7 µg/mL of PM and PM-SLN-M, respectively. SEM analysis showed that T. gondii tachyzoites were changed in both size and morphology facing with PM-SLN-M. Our findings indicated that synthesized PM-SLN-M had anti-Toxoplasma activity without significant host cell toxicity at the highest concentration. Our study demonstrated that PM was able to kill intracellular Toxoplasma in lower concentration in comparison to PM-SLN-M, although PM-SLN-M showed lower cytotoxic effects on Vero cells.

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“…Nanoformulations have also been investigated for malaria treatment. For this purpose, the activity of conventional antimalarial drugs has been enhanced, especially by encapsulation in liposomes, micelles, polymeric particles, cyclodextrin, and dendrimers [137][138][139][140][141][142]. The first work on the incorporation of traditional antimalarial drugs into liposomes was published in 1989 by Peeters et al [143,144].…”

Section: Formulation Techniquesmentioning

confidence: 99%

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

et al. 2020

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Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT, for example, of malaria parasite. However, the low efficiency generally associated with their low solubility in water and bioavailability have precluded biomedical applications. Nanotechnology can provide efficient strategies to enhance bioavailability and incorporate targeted delivery properties to conventional pharmaceuticals, enhancing the effectiveness and reducing the toxicity, thus improving the adhesion to the treatment. In this way, those limitations can be overcome by using two main strategies: (1) Incorporation of hydrophilic substituents into the macrocycle ring while controlling the interaction with biological systems and (2) by including them in nanocarriers and delivery nanosystems. This review will focus on antiparasitic drugs based on porphyrin derivatives developed according to these two strategies, considering their vast and increasing applications befitting the multiple roles of these compounds in nature.

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Nanobiotechnology as an emerging approach to combat malaria: A systematic review

Cited by 70 publications

References 73 publications

Promising nanomaterials in the fight against malaria

Promising nanomaterials in the fight against malaria

In vitro Evaluation of Mannosylated Paromomycin-Loaded Solid Lipid Nanoparticles on Acute Toxoplasmosis

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

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