Nanobiotechnology and bone regeneration: a mini-review

Gusić, Nadomir; Ivković, Alan; VaFaye, John; Vukasović, Andreja; Ivković, Jana; Hudetz, Damir; Janković, Saša

doi:10.1007/s00264-014-2412-0

Cited by 40 publications

(36 citation statements)

References 60 publications

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“…An ideal scaffold for bone regeneration must be able to induce rapid cell adhesion, proliferation, and differentiation while possessing adequate mechanical strength to sustain physiological loads [108,109]. Natural bone owes its resistance to fracture to a unique combination of structural features that range from micro- to nanoscale with a meticulous interface between various components [110].…”

Section: Nanostructure Scaffolds For Bone-healing Applicationsmentioning

confidence: 99%

Nanomedicine for safe healing of bone trauma: Opportunities and challenges

et al. 2017

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Historically, high-energy extremity injuries resulting in significant soft-tissue trauma and bone loss were often deemed unsalvageable and treated with primary amputation. With improved soft-tissue coverage and nerve repair techniques, these injuries now present new challenges in limb-salvage surgery. High-energy extremity trauma is pre-disposed to delayed or unpredictable bony healing and high rates of infection, depending on the integrity of the soft-tissue envelope. Furthermore, orthopedic trauma surgeons are often faced with the challenge of stabilizing and repairing large bony defects while promoting an optimal environment to prevent infection and aid bony healing. During the last decade, nanomedicine has demonstrated substantial potential in addressing the two major issues intrinsic to orthopedic traumas (i.e., high infection risk and low bony reconstruction) through combatting bacterial infection and accelerating/increasing the effectiveness of the bone-healing process. This review presents an overview and discusses recent challenges and opportunities to address major orthopedic trauma through nanomedical approaches.

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Section: Nanostructure Scaffolds For Bone-healing Applicationsmentioning

confidence: 99%