Nanobiotechnology: A promising scope of gold biotechnology

Barabadi, Hamed

doi:10.14715/cmb/2017.63.12.2

Cited by 50 publications

(16 citation statements)

References 16 publications

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“…Additionally, towards the treatment of toxoplasmosis as well as leishmaniasis, a recent study reported the effectiveness of silver nanoparticles (Islan et al, 2017). Specifically, silver NPs can be prepared by using physical, chemical or biological methods (Barabadi et al, 2017a(Barabadi et al, , 2017b. However, further investigations are required before these products reach the market.…”

Section: African Perspective Of Nanomedicinementioning

confidence: 99%

Barriers for the development, translation, and implementation of nanomedicine: an African perspective

Saravanan

Ramachandran

Barabadi

et al. 2018

J of Interdiscip Nanomed

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Nanotechnology is a branch of science, which empowers innovation to discover new medical technologies, improving current diagnostic and treatment methods. The scope of nanotechnology focuses mainly on "technology transfer", in which research aims to facilitate the application of recent nanoscience techniques to conventional medicine development methodologies. Nanomedicine is attractive to researchers who wish to target specific infectious diseases associated with poverty, which is highlighted through the many pertinent examples of recent breakthroughs in nanomedicine. An overview is provided in this study to highlight the barriers and implementation of nanomedicine for various infectious diseases in the African continent. Patient backgrounds provide the greatest of challenges for new technologies in terms of improving bioavailability and dosage. This review points out the current situation of nanomedicine in Africa and explores the possibility of how nanomedicine could improve patient drug regimens and wellbeing.

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Section: African Perspective Of Nanomedicinementioning

confidence: 99%

Barriers for the development, translation, and implementation of nanomedicine: an African perspective

Saravanan

Ramachandran

Barabadi

et al. 2018

J of Interdiscip Nanomed

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“…In the bottom-up approach, MNPs are synthesized at the molecular level via different chemical or biological procedures [3,5]. Among the physical, chemical, and biological methods for MNP synthesis, the biological methods are bottom-up approaches that overcome some of the unsatisfactory conditions of the physical and chemical methods (e.g., high energy or temperature requirements, hazardous waste generation, and toxic chemical use) [6,7,8]. Nanobiotechnology studies are categorized as “Gold Biotechnology” studies and involve the synthesis of MNPs by exploiting biological sources [7].…”

Section: Introductionmentioning

confidence: 99%

“…Among the physical, chemical, and biological methods for MNP synthesis, the biological methods are bottom-up approaches that overcome some of the unsatisfactory conditions of the physical and chemical methods (e.g., high energy or temperature requirements, hazardous waste generation, and toxic chemical use) [6,7,8]. Nanobiotechnology studies are categorized as “Gold Biotechnology” studies and involve the synthesis of MNPs by exploiting biological sources [7]. A number of plants [7,9,10,11], algae [12,13], fungi [14], and bacteria [15,16] have been reported to biosynthesize MNPs as ecofriendly, biocompatible, and inexpensive alternatives to conventional physical and chemical methods.…”

Section: Introductionmentioning

confidence: 99%

“…Nanobiotechnology studies are categorized as “Gold Biotechnology” studies and involve the synthesis of MNPs by exploiting biological sources [7]. A number of plants [7,9,10,11], algae [12,13], fungi [14], and bacteria [15,16] have been reported to biosynthesize MNPs as ecofriendly, biocompatible, and inexpensive alternatives to conventional physical and chemical methods. Notably, MNPs have been used in wound dressings, cell labeling, photoimaging, sensors, drug delivery, gene delivery, photothermal therapy, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, MNPs have been used in wound dressings, cell labeling, photoimaging, sensors, drug delivery, gene delivery, photothermal therapy, etc. [7]. Additionally, a recent 2018 meta-analysis reported that the cytotoxicity of biogenic MNPs in cancer cell lines was 9 times higher than that in normal cell lines, indicating much greater MNP cytotoxicity in cancer cell lines (OR = 9.004, p ˂ 0.001) [16].…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

et al. 2019

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Background and objectives: Although studies have elucidated the significant biomedical potential of biogenic metallic nanoparticles (MNPs), it is very important to explore the hazards associated with the use of biogenic MNPs. Evidence indicates that genetic toxicity causes mutation, carcinogenesis, and cell death. Materials and Methods: Therefore, we systematically review original studies that investigated the genotoxic effect of biologically synthesized MNPs via in vitro and in vivo models. Articles were systematically collected by screening the literature published online in the following databases; Cochrane, Web of Science, PubMed, Scopus, Science Direct, ProQuest, and EBSCO. Results: Most of the studies were carried out on the MCF-7 cancer cell line and phytosynthesis was the general approach to MNP preparation in all studies. Fungi were the second most predominant resource applied for MNP synthesis. A total of 80.57% of the studies synthesized biogenic MNPs with sizes below 50 nm. The genotoxicity of Ag, Au, ZnO, TiO2, Se, Cu, Pt, Zn, Ag-Au, CdS, Fe3O4, Tb2O3, and Si-Ag NPs was evaluated. AgNPs, prepared in 68.79% of studies, and AuNPs, prepared in 12.76%, were the two most predominant biogenic MNPs synthesized and evaluated in the included articles. Conclusions: Although several studies reported the antigenotoxic influence of biogenic MNPs, most of them reported biogenic MNP genotoxicity at specific concentrations and with a dose or time dependence. To the best of our knowledge, this is the first study to systematically evaluate the genotoxicity of biologically synthesized MNPs and provide a valuable summary of genotoxicity data. In conclusion, our study implied that the genotoxicity of biologically synthesized MNPs varies case-by-case and highly dependent on the synthesis parameters, biological source, applied assay, etc. The gathered data are required for the translation of these nanoproducts from research laboratories to the clinical market.

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Potential of Micro-/Nanoemulsions as a Delivery Carrier to Treat Malaria

Srivastava

Singh

et al. 2023

Malarial Drug Delivery Systems

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Nanobiotechnology: A promising scope of gold biotechnology

Cited by 50 publications

References 16 publications

Barriers for the development, translation, and implementation of nanomedicine: an African perspective

Barriers for the development, translation, and implementation of nanomedicine: an African perspective

A Systematic Review of the Genotoxicity and Antigenotoxicity of Biologically Synthesized Metallic Nanomaterials: Are Green Nanoparticles Safe Enough for Clinical Marketing?

Potential of Micro-/Nanoemulsions as a Delivery Carrier to Treat Malaria

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