Nanobiotechnological approaches in osteosarcoma therapy: Versatile (nano)platforms for theranostic applications

Jiang, Yao; He, Ke

doi:10.1016/j.envres.2023.115939

Cited by 5 publications

(2 citation statements)

References 225 publications

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“…Photodynamic therapy has been widely studied in osteosarcomas due to the drug resistance of this type of cancer; combinations of natural photosensitizers with silica nanoparticles to obtain a better bioavailability and solubility of the photosensitizer have been reported [ 126 ]. For example, Ghaseb et al used an extract from the flowers and aerial parts of chicory grass ( Cichorium pumilum ) that was loaded with silicon nanoparticles to evaluate the encapsulation effect on the efficacy of chicory as a photosensitizing agent in photodynamic therapy, with good encapsulation efficiency, increasing its capacity to absorb light and generate reactive oxygen species (ROS) [ 127 ].…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Barba-Rosado,

Carrascal-Hernández,

Insuasty

et al. 2024

Nanomaterials

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Cancer is a severe disease that, in 2022, caused more than 9.89 million deaths worldwide. One worrisome type of cancer is bone cancer, such as osteosarcoma and Ewing tumors, which occur more frequently in infants. This study shows an active interest in the use of graphene oxide and its derivatives in therapy against bone cancer. We present a systematic review analyzing the current state of the art related to the use of GO in treating osteosarcoma, through evaluating the existing literature. In this sense, studies focused on GO-based nanomaterials for potential applications against osteosarcoma were reviewed, which has revealed that there is an excellent trend toward the use of GO-based nanomaterials, based on their thermal and anti-cancer activities, for the treatment of osteosarcoma through various therapeutic approaches. However, more research is needed to develop highly efficient localized therapies. It is suggested, therefore, that photodynamic therapy, photothermal therapy, and the use of nanocarriers should be considered as non-invasive, more specific, and efficient alternatives in the treatment of osteosarcoma. These options present promising approaches to enhance the effectiveness of therapy while also seeking to reduce side effects and minimize the damage to surrounding healthy tissues. The bibliometric analysis of photothermal and photochemical treatments of graphene oxide and reduced graphene oxide from January 2004 to December 2022 extracted 948 documents with its search strategy, mainly related to research papers, review papers, and conference papers, demonstrating a high-impact field supported by the need for more selective and efficient bone cancer therapies. The central countries leading the research are the United States, Iran, Italy, Germany, China, South Korea, and Australia, with strong collaborations worldwide. At the same time, the most-cited papers were published in journals with impact factors of more than 6.0 (2021), with more than 290 citations. Additionally, the journals that published the most on the topic are high impact factor journals, according to the analysis performed, demonstrating the high impact of the research field.

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Section: Resultsmentioning

confidence: 99%

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Barba-Rosado,

Carrascal-Hernández,

Insuasty

et al. 2024

Nanomaterials

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“…Furthermore, the long-term survival rates after recurrence are below 20% [ 23 ]. Multidrug adjuvant chemotherapy regimens are employed to enhance the survival rates of patients with OS incorporating doxorubicin, cisplatin, high-dose methotrexate, and isocyclophosphamide as antagonists [ 24 , 25 ]. Nevertheless, administration of chemotherapy in high doses may result in critical and potentially fatal adverse effects [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

Chen,

Li,

et al. 2023

J Nanobiotechnol

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Background In recent years, the development of BMSCs-derived exosomes (EXO) for the treatment of osteosarcoma (OS) is a safe and promising modality for OS treatment, which can effectively deliver drugs to tumor cells in vivo. However, the differences in the drugs carried, and the binding of EXOs to other organs limit their therapeutic efficacy. Therefore, improving the OS-targeting ability of BMSCs EXOs and developing new drugs is crucial for the clinical application of targeted therapy for OS. Results In this study, we constructed a potential therapeutic nano platform by modifying BMSCs EXOs using the bone-targeting peptide SDSSD and encapsulated capreomycin (CAP) within a shell. These constructed nanoparticles (NPs) showed the ability of homologous targeting and bone-targeting exosomes (BT-EXO) significantly promotes cellular endocytosis in vitro and tumor accumulation in vivo. Furthermore, our results revealed that the constructed NPs induced ferroptosis in OS cells by prompting excessive accumulation of reactive oxygen species (ROS), Fe2+ aggregation, and lipid peroxidation and further identified the potential anticancer molecular mechanism of ferroptosis as transduced by the Keap1/Nrf2/GPX4 signaling pathway. Also, these constructed NP-directed ferroptosis showed significant inhibition of tumor growth in vivo with no significant side effects. Conclusion These results suggest that these constructed NPs have superior anticancer activity in mouse models of OS in vitro and in vivo, providing a new and promising strategy for combining ferroptosis-based chemotherapy with targeted therapy for OS.

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Versatile function of AMPK signaling in osteosarcoma: An old player with new emerging carcinogenic functions

Hashemi,

Razzazan,

Bagheri

et al. 2023

Pathology - Research and Practice

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Nanobiotechnological approaches in osteosarcoma therapy: Versatile (nano)platforms for theranostic applications

Cited by 5 publications

References 225 publications

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

Versatile function of AMPK signaling in osteosarcoma: An old player with new emerging carcinogenic functions

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