Nanobiosensor in Health Sector: The Milestones Achieved and Future Prospects

Noori, Rubia; Ahmad, Razi; Sardar, Meryam

doi:10.1007/978-981-15-8346-9_4

Cited by 7 publications

(4 citation statements)

References 151 publications

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“…Such ready access to a living cell's interior allows remarkable advantages on the clinical and basic research frontiers. These days, with unique optical properties such as fluorescence and surface plasmon resonance (SPR), nanomaterials are achieving increasing attention in biomedical applications (Wang et al, 2007;Boisselier and Astruc, 2009;Aminabad et al, 2019;Elahi et al, 2019) especially in developing optics-based analytical techniques used for bioimaging (Xia, 2008;Chisanga et al, 2019) and biosensing (Kumar et al, 2019;Celiksoy et al, 2020;Noori et al, 2020). For such biomedical applications, a metal surface's biocompatibility is a key consideration and metal nanoparticles synthesized using biological systems, provide metals ions with high biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Microbial Nano-Factories: Synthesis and Biomedical Applications

et al. 2021

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In the recent times, nanomaterials have emerged in the field of biology, medicine, electronics, and agriculture due to their immense applications. Owing to their nanoscale sizes, they present large surface/volume ratio, characteristic structures, and similar dimensions to biomolecules resulting in unique properties for biomedical applications. The chemical and physical methods to synthesize nanoparticles have their own limitations which can be overcome using biological methods for the synthesis. Moreover, through the biogenic synthesis route, the usage of microorganisms has offered a reliable, sustainable, safe, and environmental friendly technique for nanosynthesis. Bacterial, algal, fungal, and yeast cells are known to transport metals from their environment and convert them to elemental nanoparticle forms which are either accumulated or secreted. Additionally, robust nanocarriers have also been developed using viruses. In order to prevent aggregation and promote stabilization of the nanoparticles, capping agents are often secreted during biosynthesis. Microbial nanoparticles find biomedical applications in rapid diagnostics, imaging, biopharmaceuticals, drug delivery systems, antimicrobials, biomaterials for tissue regeneration as well as biosensors. The major challenges in therapeutic applications of microbial nanoparticles include biocompatibility, bioavailability, stability, degradation in the gastro-intestinal tract, and immune response. Thus, the current review article is focused on the microbe-mediated synthesis of various nanoparticles, the different microbial strains explored for such synthesis along with their current and future biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Microbial Nano-Factories: Synthesis and Biomedical Applications

et al. 2021

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“…Educating the public and engaging the community is also necessary to address socioeconomic factors. Nanobiosensors should be technologically advanced and culturally and economically sensitive [ 119 ]. The distribution of E. granulosus and its hosts can be affected by environmental factors, including climate change [ 120 , 121 ].…”

Section: Discussionmentioning

confidence: 99%

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

Hajjafari,

Sadr,

Santucciu

et al. 2024

Veterinary Sciences

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Cystic echinococcosis (CE) is a zoonotic disease affecting humans and animals. Despite a lack of clarity about many details of parasite–intermediate host interactions, the nature of the immune responses triggered by hydatid infection has revealed new perspectives. This study discusses the latest advances in elucidating the immunologic mechanism of echinococcosis and its detection and potential approaches to enhance serodiagnosis accuracy. Moreover, nanobiosensors have been evaluated according to their potential to improve treatment efficiency and aid in an early diagnosis of cystic echinococcosis. The serum of an intermediate host can diagnose CE by analyzing antibodies induced by Echinococcus granulosus. Among the most notable features of this method are its noninvasive ability and high sensitivity, both of which make it an excellent tool for clinical diagnosis. Several serological tests, including ELISAs and immunoblotting, can detect these antibodies to assess the disease’s state and determine the treatment outcome. A thorough understanding of what cross-reactivity means and the stage of the disease are crucial to interpreting serological results. Nanobiosensors have also proven better than conventional biosensors in detecting hydatid cysts. Additionally, they are highly sensitive and versatile when detecting specific biomarkers, improving diagnostic accuracy. These immunomodulatory molecules, induced by E. granulosus, are a good candidate for diagnosing cystic echinococcosis because they alter intermediate host immune responses. Hydatid cyst detection is also enhanced through nanobiosensors, which provide better accuracy.

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“…Nanomedicine has been used successfully to enhance treatment for a wide range of illnesses including neural, cancer, cardiopulmonary, and communicable diseases like HIV-1, HBV, influenza virus, and respiratory syncytial virus (Ahmad et al, 2014b;Ghosh et al, 2019Ghosh et al, , 2021aAbd Ellah et al, 2020;Srivastava et al, 2021). Nanotechnology could play a potential role in diagnosis, treatment, and prevention of COVID-19 (Bhavana et al, 2020;Campos et al, 2020;Noori et al, 2020). Furthermore, numerous CoV-related patents have been enrolled in the area of nanotechnology (Abd Ellah et al, 2020).…”

Section: Nanomedicinementioning

confidence: 99%

COVID-19 and SARS-CoV-2 Variants: Current Challenges and Health Concern

et al. 2021

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The ongoing coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China, was triggered and unfolded quickly throughout the globe by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The new virus, transmitted primarily through inhalation or contact with infected droplets, seems very contagious and pathogenic, with an incubation period varying from 2 to 14 days. The epidemic is an ongoing public health problem that challenges the present global health system. A worldwide social and economic stress has been observed. The transitional source of origin and its transport to humans is unknown, but speedy human transportation has been accepted extensively. The typical clinical symptoms of COVID-19 are almost like colds. With case fatality rates varying from 2 to 3 percent, a small number of patients may experience serious health problems or even die. To date, there is a limited number of antiviral agents or vaccines for the treatment of COVID-19. The occurrence and pathogenicity of COVID-19 infection are outlined and comparatively analyzed, given the outbreak’s urgency. The recent developments in diagnostics, treatment, and marketed vaccine are discussed to deal with this viral outbreak. Now the scientist is concerned about the appearance of several variants over the globe and the efficacy of the vaccine against these variants. There is a need for consistent monitoring of the virus epidemiology and surveillance of the ongoing variant and related disease severity.

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Nanobiosensor in Health Sector: The Milestones Achieved and Future Prospects

Cited by 7 publications

References 151 publications

Microbial Nano-Factories: Synthesis and Biomedical Applications

Microbial Nano-Factories: Synthesis and Biomedical Applications

Advances in Detecting Cystic Echinococcosis in Intermediate Hosts and New Diagnostic Tools: A Literature Review

COVID-19 and SARS-CoV-2 Variants: Current Challenges and Health Concern

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