Nanobionics of Pharmacologically Active Derivatives of Fullerene C₆₀

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems

“…132 Amino acid-modified C60s can penetrate the lipid membrane, bind to the hydrophobic domains of proteins and alter the function of membrane-bound enzymes. 140 …”

Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS)

“…As a result both computational and experimental studies have identified compounds that could inhibit the assembly of the HIV capsid. Various nanomaterials that include fullerene(c-60)-based structures and inorganic nanoparticles, such as gold and silver, have been shown to have anti-HIV activity in vitro [75][76][77]. While these efforts have not yet progressed beyond in vitro studies, they illustrate the potential of therapeutic nanomaterials to inhibit HIV replication.…”

Fullerene–biomolecule conjugates and their biomedicinal applications

“…This was discussed in comparison to D-or L-isomers' abilities to penetrate the phosphatidylcholine membranes and enter the liposome's interior. 53 A complete, in vivo, biopharmaceutical study was carried out by Rajagopalan et al, who utilized intravenous administration of a bis-monosuccinimide derivative, p,p′-bis(2-aminoethyl)-diphenyl-C 60 , 28 ( Figure 6D). 6 Derivative 28 displayed a higher affinity to tissues rather than a tendency to interact with the cellular membranes or other lipid-based structures.…”