Nanobiomaterials in hard tissue engineering

Dalí, Gabriel Castillo; Lagares, Daniel Torres

doi:10.1016/b978-0-323-42862-0.00001-8

Cited by 4 publications

(4 citation statements)

References 64 publications

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“…Human cortical bone is a complex entity comprising the bone mineral (BM), organic components, and water [1,2]. The very complex structure of the bone represents triple-helix tropocollagen molecules, self-assembled into collagen fibrils (50-100 nm in diameter and up to several µm in length), and non-collagenous proteins; collagen serves as a scaffold for BM deposition in the form of nano-sized plate-like crystallites [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Treatment of critical-sized bone defects often requires the use of scaffolds, tailored to the morphology and size of bone damage, and/or surgical construction elements. These articles must be biocompatible and might be biodegradable or not; in the latter case, the second surgical intervention for implant removal may be needed [2,7]. Similarity of the mechanical properties of bone substitutes and bone tissue is also desirable [8][9][10], e.g., conventional metal articles have the mismatch of an elastic modulus of metal with the surrounding bone, which may cause bone destruction and implant failure [11].…”

Section: Introductionmentioning

confidence: 99%

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Dispersant and Protective Roles of Amphiphilic Poly(ethylene phosphate) Block Copolymers in Polyester/Bone Mineral Composites

Nifant’ev

Tavtorkin

Komarov

et al. 2023

IJMS

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Composites of synthetic bone mineral substitutes (BMS) and biodegradable polyesters are of particular interest for bone surgery and orthopedics. Manufacturing of composite scaffolds commonly uses mixing of the BMS with polymer melts. Melt processing requires a high homogeneity of the mixing, and is complicated by BMS-promoted thermal degradation of polymers. In our work, poly(L-lactide) (PLLA) and poly(ε-caprolactone) (PCL) composites reinforced by commercial β-tricalcium phosphate (βTCP) or synthesized carbonated hydroxyapatite with hexagonal and plate-like crystallite shapes (hCAp and pCAp, respectively) were fabricated using injection molding. pCAp-based composites showed advanced mechanical and thermal characteristics, and the best set of mechanical characteristics was observed for the PLLA-based composite containing 25 wt% of pCAp. To achieve compatibility of polyesters and pCAp, reactive block copolymers of PLLA or PCL with poly(tert-butyl ethylene phosphate) (C1 and C2, respectively) were introduced to the composite. The formation of a polyester-b-poly(ethylene phosphoric acid) (PEPA) compatibilizer during composite preparation, followed by chemical binding of PEPA with pCAp, have been proved experimentally. The presence of 5 wt% of the compatibilizer provided deeper homogenization of the composite, resulting in a marked increase in strength and moduli as well as a more pronounced nucleation effect during isothermal crystallization. The use of C1 increased the thermal stability of the PLLA-based composite, containing 25 wt% of pCAp. In view of positive impacts of polyester-b-PEPA on composite homogeneity, mechanical characteristics, and thermal stability, polyester-b-PEPA will find application in the further development of composite materials for bone surgery and orthopedics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dispersant and Protective Roles of Amphiphilic Poly(ethylene phosphate) Block Copolymers in Polyester/Bone Mineral Composites

Nifant’ev

Tavtorkin

Komarov

et al. 2023

IJMS

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“…In contrast, inorganic compounds, such as glass nanoparticles, can improve mechanical properties and provide bioactivity to the device (e.g., osteoconductivity in the glass nanoparticles example) [ 4 , 5 ]. Improved mechanical properties and mineralization have found a growing interest for guided bone regeneration (GBR) since these biomaterials specialize in promoting self-reparation in bone and in surrounding damaged tissues, such as in periodontal disease [ 6 ]. The osteoconductivity of the ceramics combined with the multifunctionality of the polymers could then create mimics of the native bone extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Exploiting Polyelectrolyte Complexation for the Development of Adhesive and Bioactive Membranes Envisaging Guided Tissue Regeneration

Fonseca

Vale

Costa

et al. 2022

JFB

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Mussels secrete protein-based byssal threads to tether to rocks, ships, and other organisms underwater. The secreted marine mussel adhesive proteins (MAPs) contain the peculiar amino acid L-3,4-dihydroxyphenylalanine (DOPA), whose catechol group content contributes greatly to their outstanding adhesive properties. Inspired by such mussel bioadhesion, we demonstrate that catechol-modified polysaccharides can be used to obtain adhesive membranes using the compaction of polyelectrolyte complexes (CoPEC) method. It is a simple and versatile approach that uses polyelectrolyte complexes as building blocks that coalesce and dry as membrane constructs simply as a result of sedimentation and mild temperature. We used two natural and biocompatible polymers: chitosan (CHI) as a polycation and hyaluronic acid (HA) as a polyanion. The CoPEC technique also allowed the entrapment of ternary bioactive glass nanoparticles to stimulate mineralization. Moreover, combinations of these polymers modified with catechol groups were made to enhance the adhesive properties of the assembled membranes. Extensive physico-chemical characterization was performed to investigate the successful production of composite CoPEC membranes in terms of surface morphology, wettability, stability, mechanical performance, in vitro bioactivity, and cellular behavior. Considering the promising properties exhibited by the obtained membranes, new adhesives suitable for the regeneration of hard tissues can be envisaged.

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“…Guided tissue regeneration (GTR) is a dentistry technique based on the use of polymeric biomembranes as physical barriers for selective cell exclusion, directing the growth of gingival tissue, bone tissue, and periodontal ligaments in a region previously affected by periodontitis (Castillo Dalí and Torres Lagares, 2016;Zhang et al, 2016;Bhavsar et al, 2018). Conventionally, the basic requirements for GTR membranes are good flexibility and biocompatibility, as well as suitable biodegradation profile and physicochemical/mechanical properties (Sgorla et al, 2016;Osathanon et al, 2017;Khorsand et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Lidocaine- and chloramphenicol-loaded nanoparticles embedded in a chitosan/hyaluronic acid/glycerol matrix: Drug-eluting biomembranes with potential for guided tissue regeneration

Vasconcelos

Silva²,

Sousa-Junior³

et al. 2022

Front. Nanotechnol.

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Guided tissue regeneration (GTR) is a dentistry technique based on the use of polymeric biomembranes as physical barriers for selective cell exclusion, directing the growth of gingival tissue, bone tissue, and periodontal ligaments in a region previously affected by periodontitis. Postoperative pain and microbial infection constitute, however, two major challenges to be tackled right after implantation. To address these challenges, we prepared and characterized eight chitosan/hyaluronic acid/glycerol (CS/HA/GL) bioresorbable membranes embedded with lidocaine- and chloramphenicol-loaded polycaprolactone nanoparticles (LDNP and CHNP, respectively), combining the local anesthetic effects of lidocaine with the antibacterial effects of chloramphenicol. The formulations were prepared with varying amounts of CS, HA, GL, LDNP, and CHNP. As a plasticizing agent, GL could modulate the samples mechanical properties such as thickness, morphology, tensile strength, elongation at break, as well as swelling and degradation in simulated saliva. Two samples exhibited greater resistance to biodegradation and were selected for further studies. Their drug release profiles indicated that LDNP and CHNP first detach from the membrane matrix, and a zeroth order drug release kinetics from the detached NPs dominates the overall process thereafter, with lidocaine being released 3 times faster than chloramphenicol, in a controlled and sustained rate over time. Drug encapsulation efficiency was such that optimal samples exhibited bactericidal activity (inhibition halos) against gram-positive S. aureus and gram-negative A. actinomycetemcomitans strains similar to that observed for free chloramphenicol. Finally, one of these samples showed no intrinsic toxicity against healthy mammalian model cells (99% viability for the unloaded membrane; 80% viability for the fully LDNP- and CHNP-loaded membrane), and may now be further optimized as a drug-eluting biomembrane with potential for GTR.

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Nanobiomaterials in hard tissue engineering

Cited by 4 publications

References 64 publications

Dispersant and Protective Roles of Amphiphilic Poly(ethylene phosphate) Block Copolymers in Polyester/Bone Mineral Composites

Dispersant and Protective Roles of Amphiphilic Poly(ethylene phosphate) Block Copolymers in Polyester/Bone Mineral Composites

Exploiting Polyelectrolyte Complexation for the Development of Adhesive and Bioactive Membranes Envisaging Guided Tissue Regeneration

Lidocaine- and chloramphenicol-loaded nanoparticles embedded in a chitosan/hyaluronic acid/glycerol matrix: Drug-eluting biomembranes with potential for guided tissue regeneration

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