NanoBio challenge: Investigation of antimicrobial effect by combining ZnO nanoparticles with plant extract Eleagnus angustifolia

Çelebi, Demet; Cinisli, Kağan Tolga; Çelebi, Özgür

doi:10.1016/j.matpr.2021.02.484

Cited by 2 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When analyzed using DLS, gel nanoparticles such as calcium‐alginate and chitosan are in a swollen state in water (seven times the size of their dried counterparts) but collapse once the sample is dried out before being viewed using TEM or SEM, eliminating the swelling effect. Similarly, earlier Research on alginate‐chitosan nanoparticles showed 4–5 times lower particle sizes than those seen with DLS [24,25] . The PDI value of E. angustifolia ‐loaded ALG/CS NPs was 0.681 as opposed to 0.697 for blank ALG/CS NPs, demonstrating a narrow and desirable particle size distribution.…”

Section: Resultssupporting

confidence: 51%

“…Similarly, earlier Research on alginate-chitosan nanoparticles showed 4-5 times lower particle sizes than those seen with DLS. [24,25] The PDI value of E. angustifolia-loaded ALG/CS NPs was 0.681 as opposed to 0.697 for blank ALG/CS NPs, demonstrating a narrow and desirable particle size distribution. The PDI is a number that varies from 0 to 1.…”

Section: Characterization Of E Angustifolia-alg/cs Npsmentioning

confidence: 96%

See 1 more Smart Citation

Designing Alginate/Chitosan Nanoparticles Containing Echinacea angustifolia: A Novel Candidate for Combating Multidrug‐Resistant Staphylococcus aureus

Taghiloo

Ghajari

Zand

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

Nanoparticles (NPs) may help treat multidrug-resistant Staphylococcus aureus (MDR). This study prepared and evaluated chitosan/alginate-encapsulated Echinacea angustifolia extract against MDR strains. Evaluating synthesized NPs with SEM, DLS, and FT-IR. Congo red agar and colorimetric plate techniques examined isolate biofilm formation. NP antibacterial power was assessed using well diffusion. Real-time PCR assessed biofilmforming genes. MTT assessed the synthesized NPs' toxicity. According to DLS measurements, spherical E. angustifolia NPs had a diameter of 335.3 � 1.43 nm. The PDI was 0.681, and the entrapment effectiveness (EE%) of the E. angustifolia extract reached 83.45 %. Synthesized NPs were most antimicrobial. S. aureus resistant to several treatments was 80 percent of 100 clinical samples. Biofilm production was linked to MDR in all strains. The ALG/CS-encapsulated extract had a 4 to 32-fold lower MIC than the free extract, which had no bactericidal action. They also significantly decreased the expression of genes involved in biofilm formation. E. angustifolia-encapsulated ALG/CS decreased IcaD, IcaA, and IcaC gene expression in all MDR strains (***p < 0.001). Free extract, free NPs, and E. angustifolia-NPs had 57.5 %, 85.5 %, and 90.0 % cell viability at 256 μg/ml. These discoveries could assist generate stable plant extracts by releasing natural-derived substances under controlled conditions.

show abstract

Section: Resultssupporting

confidence: 51%

Section: Characterization Of E Angustifolia-alg/cs Npsmentioning

confidence: 96%

Designing Alginate/Chitosan Nanoparticles Containing Echinacea angustifolia: A Novel Candidate for Combating Multidrug‐Resistant Staphylococcus aureus

Taghiloo

Ghajari

Zand

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…emergence of the MRSA epidemic has encouraged new antibacterial agent research and the development of creative strategies (Rasmussen et al, 2011). Plant-based antimicrobial agents have become more signi cant in treating infectious ailments in recent years due to the rise of antibiotic-resistant pathogens (Celebi et al, 2021). Antibacterial activity in formulations has drawn increased scienti c attention as one of the possible uses of chitosan-alginate-based nanomaterials.…”

Section: Discussionmentioning

confidence: 99%

Echinacea angustifolia encapsulated with alginate/chitosan nanoparticles as a novel candidate carrier for combating multidrug-resistant Staphylococcus aureus

Taghiloo

Piri‐Gharaghie²,

Zand

et al. 2022

Preprint

View full text Add to dashboard Cite

Background and aim: The urgent need for breakthrough therapeutic approaches for multi-drug resistance Staphylococcus aureus (MDR) has drawn attention to potential cutting-edge tools like nanoparticles (NPs). The preparation of chitosan/alginate-encapsulated Echinacea angustifolia extract and evaluation of its effectiveness against MDR strains were the goals of this investigation. Method Scanning electron microscopy, dynamic light scattering (DLS), and Fourier Transform Infrared spectroscopy were used to analyze the synthesized NPs. Investigations were done into the antibacterial and antibiofilm properties of E. angustifolia NPs. Also, the expression of essential genes in biofilm formation was evaluated by real-time PCR. Results According to DLS measurements, spherical E. angustifolia NPs had a diameter of 335.3 ± 1.43 nm. The PDI was 0.681, and the entrapment effectiveness (EE%) of the E. angustifolia extract reached 83.45%. Synthesized NPs had the highest antibacterial power. They also significantly decreased the expression of genes involved in biofilm formation. Conclusion By releasing natural-derived medications under regulated conditions, the findings described here should help create new plant extracts with increased stability and antibacterial action, which will help minimize the usage of antibiotics.

show abstract

NanoBio challenge: Investigation of antimicrobial effect by combining ZnO nanoparticles with plant extract Eleagnus angustifolia

Cited by 2 publications

References 11 publications

Designing Alginate/Chitosan Nanoparticles Containing Echinacea angustifolia: A Novel Candidate for Combating Multidrug‐Resistant Staphylococcus aureus

Designing Alginate/Chitosan Nanoparticles Containing Echinacea angustifolia: A Novel Candidate for Combating Multidrug‐Resistant Staphylococcus aureus

Echinacea angustifolia encapsulated with alginate/chitosan nanoparticles as a novel candidate carrier for combating multidrug-resistant Staphylococcus aureus

Contact Info

Product

Resources

About