Nanobacteria and calcinosis cutis

Morgan, Michael B.

doi:10.1034/j.1600-0560.2002.290308.x

Cited by 19 publications

(14 citation statements)

References 13 publications

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“…The role of nanobacteria, which are capable of precipitating calcium salts, is, however, yet unproven. 19 We assume he developed dystrophic calcification after the snakebite over the intervening symptom-free 5 years.…”

Section: Discussionmentioning

confidence: 99%

Dystrophic calcification and a snake in the grass

Padhi¹,

Padhi²,

Choudhrie³

et al. 2005

Injury Extra

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A 45-year-old farmer presented with discharging sinii of the left leg, 5 years after snakebite at the same site. The snake had been identified as a non-poisonous wolf snake and the tissues then had developed a localised inflammatory reaction. These symptoms resolved completely within a fortnight and the patient was well for the intervening period. Six months ago, he developed fever and a painful swelling in the same leg. A general practitioner treated him with antibiotics and he recovered. Two weeks before presentation he developed discharging sinii of the left leg and was referred to us for expert orthopaedic evaluation. On examination, he was found to have a firm tender swelling over the anterolateral aspect of the left leg and two discharging sinii proximal to his lateral malleolus. He was afebrile and did no have any regional enlargement of his lymph nodes. The rest of his examination was normal.X-ray ( Fig. 1) showed diffuse new bone formation around the fibular diaphysis.Laboratory investigations revealed a total leukocyte count of 13,000/dl with a normal differential and an erythrocyte sedimentation rate (ESR at 60 min) of 46 mm. Other investigations included a peripheral blood smear for sickling, which was negative, and serum calcium level that was within acceptable limits. The chest radiograph was normal.He was clinically diagnosed to have chronic osteomyelitis of the left fibula probably secondary to the snakebite. He was scheduled to undergo curettage and debridement of the sinii.Under spinal anaesthesia and a pneumatic tourniquet, an incision was made over the anterolateral compartment of the left leg extending over most of the length. Within the anterior group of muscle, sheets of calcified tissues were found (Fig. 2). These were intermingled with the fascial planes. The tibial and fibular surfaces were free of any involucrum or new bone. There was little pus within the tissues. The cavity created by debridement was extensively curetted and irrigated before closure.The post-operative X-ray (Fig. 3) showed clearance of the diffuse opacity in the left leg. The wound healed satisfactorily and the patient was discharged on the 5th post-operative day.Histopathological examination of the excised tissue was reported as dystrophic calcification and necrosis with acute inflammatory processes. The patient has been advised regular follow-up. DiscussionThis patient suffered from snakebite on the left leg. Till he presented to us, he seemed to have recovInjury Extra (2005) 36, 537-541

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Section: Discussionmentioning

confidence: 99%

Dystrophic calcification and a snake in the grass

Padhi¹,

Padhi²,

Choudhrie³

et al. 2005

Injury Extra

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“…The cause of these entities remains unknown. [15] DC is common in childhood in the presence of such diseases as dermatomyositis, systemic scleroderma, CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome, morphea, subcutaneous fat necrosis of the newborn, and cutaneous neoplasms. Neri et al .…”

Section: Discussionmentioning

confidence: 99%

“…[16] Idiopathic scrotal calcification is seen more often than the other two. [141517] A vulvar counterpart is also reported. [1415] There is also a “milia-like” form that occurs on the hands, and face, of some patients with Down syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Multiple sub-epidermal calcified nodule mimicking eruptive xanthoma: A case report and review of the literature

et al. 2013

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Sub-epidermal calcified nodule (SCN) is an uncommon form of idiopathic calcinosis. It usually occurs in children, particularly in the head and neck region, presenting as a solitary, painless, yellow-white nodule with papillomatous features. These lesions occur twice as common in males compared with females. The pathogenesis is uncertain, but the clinical and histological features of this lesion are distinctive. We report a case of 22-year-old man with multiple nodules bilaterally located on the dorsum of hands simulating eruptive xanthoma. Histopathological examination of one of the excised lesion confirmed the diagnosis showing epidermal and sub-epidermal deposition of calcium. This paper presents a review of the literature and adds a new case of SCN.

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“…Other authors have opined that SCNs arise as a result of trauma, representing dystrophic calcification [2]. It is currently thought unlikely that SCNs arise from nevus cells, from calcification of sweat ducts or hair follicles or from nanobacterial activity [2, 3, 10]. …”

Section: Discussionmentioning

confidence: 99%

Subepidermal Calcified Nodules

Carvounis

Santi²,

Stern³

et al. 2005

Ophthalmologica

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Subepidermal calcified nodules (SCNs) are uncommon, benign lesions usually presenting in childhood which occasionally involve the eyelids. Only a handful of cases have been reported in the ophthalmologic literature. We present 2 cases, one in a 7-year-old Hispanic boy, the other in a 13-year-old African American boy, with eyelid lesions which were clinically thought to be possible juvenile xanthogranuloma, but which on histopathologic examination showed the characteristic features of SCNs.

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Nanobacteria and calcinosis cutis

Abstract: The dystrophic calcification that occurs in conjunction with the above entities does not likely involve a bacterial-induced etiology. The cause of these entities remains unknown.

Cited by 19 publications

References 13 publications

Dystrophic calcification and a snake in the grass

Dystrophic calcification and a snake in the grass

Multiple sub-epidermal calcified nodule mimicking eruptive xanthoma: A case report and review of the literature

Subepidermal Calcified Nodules

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