Nanobacteria: An infectious cause for kidney stone formation

Çiftçioğlu, Neva; Björklund, Mikael; Kuorikoski, Kai; Bergström, Kim A.; Kajander, E. Olavi

doi:10.1046/j.1523-1755.1999.00755.x

Cited by 191 publications

(177 citation statements)

References 22 publications

(7 reference statements)

Supporting

Mentioning

162

Contrasting

Unclassified

Order By: Relevance

“…Deficiencies in several macromolecules that inhibit crystallization of matrix in urine have also been suggested as a contributory factor to calculogenesis (Griffin 1998, Atmani & Khan 1999. Uroliths have been linked to nanobacterial infection but dietary factors influence their progression (Ciftcioglu et al 1999).…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Clinical and pathological study of an outbreak of obstructive urolithiasis in feedlot cattle in southern Brazil

et al. 2003

View full text Add to dashboard Cite

The epidemiology, clinical picture and pathology of an outbreak of urolithiasis in cattle in southern Brazil are described. The disease occurred in August 1999 in a feedlot beef cattle herd. Five out of 1,100 castrated steers were affected. Clinical signs included colic and ventral abdominal distension. White, sand-grain-like mineral deposits precipitated on the preputial hairs. Affected cattle died spontaneously 24-48 hrs after the onset of the clinical signs. Only one animal recovered after perineal urethrostomy. Necropsy findings included calculi blocking the urethral lumen of the distal portion of the penile sigmoid flexure, urinary bladder rupture with leakage of urine into the abdominal cavity and secondary fibrinous peritonitis. Daily water intake was low since water sources were scarce and not readily available. The animals were fed rations high in grains and received limited amounts of roughage. Biochemical analysis revealed that the calculi were composed of ammonium phosphate. A calcium-phosphorus imbalance (0.4:0.6) was detected in the feedlot ration. For the outbreak, it is suggested that contributing factors to urolith formation include insufficient fiber ingestion, low water intake and high dietary levels of phosphorus. No additional cases were observed in that feedlot after preventive measures were established. Similar dietary mismanagement in fattening steers has been associated with obstructive urolithiasis in feedlot beef cattle in other countries.

show abstract

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Clinical and pathological study of an outbreak of obstructive urolithiasis in feedlot cattle in southern Brazil

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Proteins that have crystal binding affinity could play an important role in mediating the earliest events in both atherosclerosis and KS formation (34). There are also studies that investigated nanobacteria, which are supposed to be an etiological factor for both KSs and calcified human arteries (35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of carotid artery calcification on panoramic radiographs in patients with renal stones

Üstün¹,

İnci²,

Demirtaş³

et al. 2013

Turk J Med Sci

View full text Add to dashboard Cite

Novel symmetrical 3,6-bis [(25,26,27-tripropoxy-28-(3-(4-iodophenyl)propoxy)-p-tert -butyl calix [4]arene ethynyl]-9H-fluoren-9-one with a cone conformation was synthesized by palladium-catalyzed coupling of (25,26,27-tripropoxy-28-(3-(4-iodophenyl)propoxy)-p -tert -butyl calix [4]arene and 3,6-diethynyl-9H-fluoren-9-one. Its structure was confirmed by FT-IR, 1 H-NMR, and 13 C-NMR spectroscopy, and elemental analysis and positive ion FAB mass spectrometry.

show abstract

“…They are isolated in pure culture of lesion (nanobacteria are detected in demineralization of stones in 1N HCl). 16 3. Inoculation of nanobacteria reproduce the pathologic calcification (Garcia Cuerpo et al found that translumbar, percutaneous intrarenal injection of calcifying nanoparticles that is isolated from kidney stones into rats resulted in kidney stone formation).…”

Section: Nanobacteria: Fact or Fictionmentioning

confidence: 99%

“…40 On screening of demineralized kidney stones using a double staining method, scanning electron microscopy and specific culture method 93.1% stones contain nanobacteria and after compilation of all the assay results 70 out of 72 (97.2%) renal stones were positive for nanobacteria. 16 Moreover, the risk of urolithiasis recurrence may be reduced with antinanobacterial therapy. 41 …”

Section: Nanobacteria and Renal Stonesmentioning

confidence: 99%

An Overview on Clinical Implications of Nanobacteria

Kumar¹,

Bagga²,

Mohan³

et al. 2011

JIAOMR

View full text Add to dashboard Cite

Pathological calcification is becoming recognized as an important feature in the dynamics of a variety of diseases, such as renal stone, atherosclerosis, pulp stones, scleroderma and arthritis, etc. from which millions of human beings suffer in all ages. Nanobacterium sanguineum is the first calcium phosphate mineral containing nanoorganism isolated from human blood that causes pathological disease calcification in humans. Nanobacteria are the smallest cell-walled bacteria, recently discovered in human and cow blood and commercial cell culture serum. Here in the article controversy and critical role of calcifying nanoparticles as nidi and triggering factor in human pathologic calcifications are discussed.

show abstract

Nanobacteria: An infectious cause for kidney stone formation

Abstract: We propose that kidney stone formation is a nanobacterial disease analogous to Helicobacter pylori infection and peptic ulcer disease. Both diseases are initiated by bacterial infection and subsequently endogenous and dietary factors influence their progression.

Cited by 191 publications

References 22 publications

Clinical and pathological study of an outbreak of obstructive urolithiasis in feedlot cattle in southern Brazil

Clinical and pathological study of an outbreak of obstructive urolithiasis in feedlot cattle in southern Brazil

Prevalence of carotid artery calcification on panoramic radiographs in patients with renal stones

An Overview on Clinical Implications of Nanobacteria

Contact Info

Product

Resources

About