Nanoassemblies Derived from Natural Flavonoid Compounds as New Antioxidant Oral Preparations for Targeted Inflammatory Bowel Disease Therapy

Abstract

Possessing the largest surface area of mucosa in the body, the gastrointestinal (GI) tract can easily sufferfrom inflammatory damage under various adverse external exposures, resulting in the occurrence of inflammatory bowel disease (IBD). Excessive reactive oxygen species (ROS) usually lead to local mucosal injury, accelerate the formation of niduses, andamplify the inflammatory and immune response. Antioxidant therapy, therefore, is considered as a potential strategy against IBDs. Herein, a series of novel dihydromyricetin‐based nanoassemblies with excellent antioxidant activities and high dispersion in GI tract as oral preparations are developed for the targeted IBD treatment. By changing raw materials, the current strategy can be well extended to the preparation of other insoluble natural flavonoid compound‐based nanoassemblies. The well‐designed dihydromyricetin‐PEG 1000‐based nanoassemblies (DMY‐1000 NAs) with high stability and great ROS scavenging capacity in the harsh environment of GI tract hold an admirable targeted capability toward the intestinal inflamed lesions. Therefore, these biocompatible DMY‐1000 NAs show promising therapeutic effects for typical IBDs including ulcerative colitis and Crohn's disease in murine models. This study not only provides a new method for constructing antioxidant therapy platforms but also illustrates their prominent therapeutic promise against IBDs.

Highly Crystalline Copper Aluminum-Layered Double Hydroxides with Intrinsic Fenton-Like Catalytic Activity for Robust Oral Health Management

“…Before CuAl-LDHs were utilized in the biomedical fields, a comprehensive evaluation of their systemic toxicity was done at first. , Based on CCK-8 assay and live/dead staining, CuAl-LDHs showed no obvious cytotoxicity on the viability of L929 cells at all of the working concentrations (Figure S13). The hemocompatibility of CuAl-LDHs was then explored by using hemolysis assay and blood coagulation assay.…”

Radical Reactions with N-Heterocyclic Carbene (NHC)-Derived Acyl Azoliums for Access to Multifunctionalized Ketones

“…It is worth noting that ketone molecules bearing diverse functionalities can be efficiently obtained through radical reactions with the NHC-derived acyl azoliums. Ketones have found broad applications in the development of medicines, agrochemicals, and materials that are significant to the health, safety, and green manufactures in human society . Moreover, the ketone synthetic methods through radical reactions involving NHC-derived acyl azoliums could get rid of the stoichiometric amount of metal reductants that are necessary in traditional metal-catalyzed reductive cross-coupling protocols for ketone synthesis.…”