Nanoarchitectonics of Layer-by-Layer (LbL) coated nanostructured lipid carriers (NLCs) for Enzyme-Triggered charge reversal

Akkuş‐Dağdeviren, Zeynep Burcu; Fürst, Andrea; Friedl, Julian David; Tribus, Martina; Bernkop‐Schnürch, Andreas

doi:10.1016/j.jcis.2022.08.190

Cited by 13 publications

(7 citation statements)

References 47 publications

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“…This result is in agreement with previous studies showing that polyphosphates used as coating for nanoemulsions 48 and nanostructured lipid carriers (NLCs) are also cleaved by IAP. 27 , 49 , 50 Similarly, in a previous study, authors developed polyethylene imine (PEI)–PP NPs to overcome the mucus gel layer and to enable a charge conversion at the epithelial cell membrane showing monophosphate release from these particles in the presence of IAP. 16 …”

Section: Resultsmentioning

confidence: 99%

Peptide Antibiotic–Polyphosphate Nanoparticles: A Promising Strategy to Overcome the Enzymatic and Mucus Barrier of the Intestine

et al. 2023

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The aim of this study was to develop peptide antibiotic–polyphosphate nanoparticles that are able to overcome the enzymatic and mucus barriers providing a targeted drug release directly on the intestinal epithelium. Polymyxin B–polyphosphate nanoparticles (PMB–PP NPs) were formed via ionic gelation between the cationic peptide and the anionic polyphosphate (PP). The resulting NPs were characterized by particle size, polydispersity index (PDI), zeta potential, and cytotoxicity on Caco-2 cells. The protective effect of these NPs for incorporated PMB was evaluated via enzymatic degradation studies with lipase. Moreover, mucus diffusion of NPs was investigated with porcine intestinal mucus. Isolated intestinal alkaline phosphatase (IAP) was employed to trigger the degradation of NPs and consequent drug release. PMB–PP NPs exhibited an average size of 197.13 ± 14.13 nm, a PDI of 0.36, a zeta potential of −11.1 ± 3.4 mV and a concentration and time-dependent toxicity. They provided entire protection toward enzymatic degradation and exhibited significantly (p < 0.05) higher mucus permeating properties than PMB. When incubated with isolated IAP for 4 h, monophosphate and PMB were constantly released from PMB–PP NPs and zeta potential raised up to −1.9 ± 0.61 mV. According to these findings, PMB–PP NPs are promising delivery systems to protect cationic peptide antibiotics against enzymatic degradation, to overcome the mucus barrier and to provide drug release directly at the epithelium.

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Section: Resultsmentioning

confidence: 99%

Peptide Antibiotic–Polyphosphate Nanoparticles: A Promising Strategy to Overcome the Enzymatic and Mucus Barrier of the Intestine

et al. 2023

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“…A shift in zeta potential from −12 mV to almost neutral confirmed the cleavage of PP by alkaline phosphatase within the biofilm formed by Candida albicans, improving antifungal efficacy. [156] Da Costa et al generated poly-lactic acid (PLA) negatively charged NPs encapsulating rifampicin. Results showed a higher biofilm penetration in comparison to positively charged NPs.…”

Section: Targeting Pathogenic Microorganismsmentioning

confidence: 99%

“…[ 79 ] The layer‐by‐layer coating method with tripolyphosphate was applied in a recent study exemplifying possibilities of a tunable surface charge. [ 117 ] In another study, NPs exposing a cationic CPP on their surface were coated with Graham's salt to shield the cationic CPP and to provide a negatively charged surface. Deshielding of CPP and charge reversal were triggered by intestinal alkaline phosphatase and facilitated cellular uptake.…”

Section: Applications For Charge‐reversible Nanoparticlesmentioning

confidence: 99%

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis

Veider,

Sanchez Armengol,

Bernkop‐Schnürch

2023

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The past two decades have witnessed a rapid progress in the development of surface charge‐reversible nanoparticles (NPs) for drug delivery and diagnosis. These NPs are able to elegantly address the polycation dilemma. Converting their surface charge from negative/neutral to positive at the target site, they can substantially improve delivery of drugs and diagnostic agents. By specific stimuli like a shift in pH and redox potential, enzymes, or exogenous stimuli such as light or heat, charge reversal of NP surface can be achieved at the target site. The activated positive surface charge enhances the adhesion of NPs to target cells and facilitates cellular uptake, endosomal escape, and mitochondrial targeting. Because of these properties, the efficacy of incorporated drugs as well as the sensitivity of diagnostic agents can be essentially enhanced. Furthermore, charge‐reversible NPs are shown to overcome the biofilm formed by pathogenic bacteria and to shuttle antibiotics directly to the cell membrane of these microorganisms. In this review, the up‐to‐date design of charge‐reversible NPs and their emerging applications in drug delivery and diagnosis are highlighted.

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“…Due to the advantages of simple LbL assembly process, applied to different building blocks and substrates, and customizable film structure and thickness, the LbL assembly technique is heavily used in the preparation of anticorrosion coatings. [7][8][9][10][11][12][13] Polymer coatings are prepared by depositing functional materials. Often these functional materials do not bond effectively with the substrate being deposited and current techniques usually require plasma, corona, chemical or even flame and thermal steps.…”

Section: Introductionmentioning

confidence: 99%

“…Decher et al [6] initially proposed the layer‐by‐layer (LbL) assembly technique, and the driving facctors between two neighboring layers in LbL assembly technique can inclcude electrostatic interactions, hydrogen bonds, coordination bonds, charge transfer interactions, etc. Due to the advantages of simple LbL assembly process, applied to different building blocks and substrates, and customizable film structure and thickness, the LbL assembly technique is heavily used in the preparation of anticorrosion coatings [7–13] . Polymer coatings are prepared by depositing functional materials.…”

Section: Introductionmentioning

confidence: 99%

Mussel‐inspired Self‐assembly into Polymer Coatings of Different Molecular Weight Electrolytes for Enhanced Self‐healing and Corrosion Properties

Zhang

Sheng

et al. 2023

Chemistry An Asian Journal

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Self‐healing coatings offer tremendous application prospects in the field of preventing metal corrosion because of their superior functionality. The coordination of barrier performance and self‐healing ability, however, continues to be difficult. Herein, a polymer coating based on polyethyleneimine (PEI) and polyacrylic acid (PAA) with self‐repairing and barrier ability was designed. Introducing the catechol group into the anti‐corrosion coating increases the adhesion and self‐healing efficiency of the coating, providing a guarantee for the long‐term stable bonding between the anti‐corrosion coating and the metal substrate. Small molecular weight PAA polymers are added to polymer coatings to increase their self‐healing capabilities and corrosion resistance. Because layer‐by‐layer assembly creates reversible hydrogen bonds and electrostatic bonds that help the coating repair itself when it is damaged, and because the traction of small molecular weight polyacrylic acid speeds up this process. When polyacrylic acid (PAA) with a molecular weight of 2000 was present in the coating at a concentration of 1.5 mg/mL. The PEI‐C/PAA45W‐PAA2000 coating has the fastest self‐healing, and the corrosion resistance efficiency (Pe) was as high as 90.1%. The polarization resistance (Rp) was maintained at 7.67×104 Ω∙cm2 after immersion for more than 240 h. It was better than other samples in this work.

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Nanoarchitectonics of Layer-by-Layer (LbL) coated nanostructured lipid carriers (NLCs) for Enzyme-Triggered charge reversal

Cited by 13 publications

References 47 publications

Peptide Antibiotic–Polyphosphate Nanoparticles: A Promising Strategy to Overcome the Enzymatic and Mucus Barrier of the Intestine

Peptide Antibiotic–Polyphosphate Nanoparticles: A Promising Strategy to Overcome the Enzymatic and Mucus Barrier of the Intestine

Charge‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis

Mussel‐inspired Self‐assembly into Polymer Coatings of Different Molecular Weight Electrolytes for Enhanced Self‐healing and Corrosion Properties

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