Nanoarchitectonics of a Skin-Adhesive Hydrogel Based on the Gelatin Resuscitation Fluid Gelatinol®

Abstract

Hydrogel materials are one of the most versatile representatives of biomaterials. Their widespread use in medical practice is due to their similarity to native biostructures regarding relevant properties. This article discusses the synthesis of hydrogels based on a plasma-substituting Gelatinol® solution and modified tannin, carried out by direct mixing of the two solutions and brief heating. This approach makes it possible to obtain materials based on precursors that are safe for humans, while having antibacterial activity and high adhesion to human skin. Thanks to the synthesis scheme used, it is possible to obtain hydrogels with a complex shape before use, which is relevant in cases where industrial hydrogels do not fully satisfy the end use regarding their form factor. Using IR spectroscopy and thermal analysis, the distinctive aspects of mesh formation were shown in comparison with the hydrogels based on ordinary gelatin. A number of application properties, such as the physical and mechanical characteristics, permeability to oxygen/moisture, and antibacterial effect, were also considered. The sorption parameters of the material were characterized in a set of physiological buffers (pH 2–9) using Fick’s first law and a pseudo-second order equation. The adhesive shear strength was determined in a model system. The synthesized hydrogels showed potential for the further development of materials based on plasma-substituting solutions.

Novel Hydrophilic Oligomer-Crosslinked Gelatin-Based Hydrogels for Biomedical Applications

“…The physicochemical characteristics of these hydrogels have been modified over time by researchers to create "smart" or "intelligent" hydrogels that respond to environmental factors such as temperature, acid levels, light, magnetic and electric fields, ionic strength, or the enzymatic environment [2,3]. Such hydrogels have demonstrated significant promise in non-invasive, remote-controlled therapies, including targeted drug administration, prosthetics, implant coatings, wound healing, regenerative medication, tissue engineering, and artificial organ implantation [1,4,5]. Several therapeutic agents can be encapsulated into hydrogels, which can adapt to any shape of the defect and surrounding tissue.…”