Nanoarchitectonics is an emerging drug/gene delivery and targeting strategy -a critical review

Karthik, Vivekanandhan; Poornima, Shanmugam; Arumugam, Vigneshwaran; Raj, Daniel Paul Raj Dharun Daniel; Subbaiya, Ramasamy; Manikandan, S.; Saravanan, Muthupandian

doi:10.1016/j.molstruc.2021.130844

Cited by 13 publications

(5 citation statements)

References 117 publications

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“…These fields can either attract or repel, depending on the relative orientation and shape of the particles. They provide a means for crafting innovative structures and materials with customizable properties, such as density, stiffness, permeability, or optical response [ 152 ].…”

Section: Dynamic Assembly Methodsmentioning

confidence: 99%

Advances in Nanoarchitectonics: A Review of “Static” and “Dynamic” Particle Assembly Methods

Eftekhari,

Parakhonskiy,

Grigoriev

et al. 2024

Materials

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Particle assembly is a promising technique to create functional materials and devices from nanoscale building blocks. However, the control of particle arrangement and orientation is challenging and requires careful design of the assembly methods and conditions. In this study, the static and dynamic methods of particle assembly are reviewed, focusing on their applications in biomaterial sciences. Static methods rely on the equilibrium interactions between particles and substrates, such as electrostatic, magnetic, or capillary forces. Dynamic methods can be associated with the application of external stimuli, such as electric fields, magnetic fields, light, or sound, to manipulate the particles in a non-equilibrium state. This study discusses the advantages and limitations of such methods as well as nanoarchitectonic principles that guide the formation of desired structures and functions. It also highlights some examples of biomaterials and devices that have been fabricated by particle assembly, such as biosensors, drug delivery systems, tissue engineering scaffolds, and artificial organs. It concludes by outlining the future challenges and opportunities of particle assembly for biomaterial sciences. This review stands as a crucial guide for scholars and professionals in the field, fostering further investigation and innovation. It also highlights the necessity for continuous research to refine these methodologies and devise more efficient techniques for nanomaterial synthesis. The potential ramifications on healthcare and technology are substantial, with implications for drug delivery systems, diagnostic tools, disease treatments, energy storage, environmental science, and electronics.

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Section: Dynamic Assembly Methodsmentioning

confidence: 99%

Advances in Nanoarchitectonics: A Review of “Static” and “Dynamic” Particle Assembly Methods

Eftekhari,

Parakhonskiy,

Grigoriev

et al. 2024

Materials

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“…In recent years, liposomes, polymeric micelles, nanogels, inorganic nanoparticles, and inorganic/organic (core/shell) nanoparticles have been widely used as NDDS in pre-clinical applications and clinical research [ 13 ]. These systems can improve the pharmacological and pharmaceutical properties of drugs by extending the time of action, improving the efficacy and targeting, overcoming drug resistance, and reducing immunogenicity and toxicity [ 14 , 15 ]. Nowadays, more and more NDDS are being applying in the preclinical and clinical phases [ 16 ].…”

Section: Antimicrobial Nanomedicine Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

et al. 2022

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Infectious diseases are among the major health issues of the 21st century. The substantial use of antibiotics over the years has contributed to the dissemination of multidrug resistant bacteria. According to a recent report by the World Health Organization, antibacterial (ATB) drug resistance has been one of the biggest challenges, as well as the development of effective long-term ATBs. Since pathogens quickly adapt and evolve through several strategies, regular ATBs usually may result in temporary or noneffective treatments. Therefore, the demand for new therapies methods, such as nano-drug delivery systems (NDDS), has aroused huge interest due to its potentialities to improve the drug bioavailability and targeting efficiency, including liposomes, nanoemulsions, solid lipid nanoparticles, polymeric nanoparticles, metal nanoparticles, and others. Given the relevance of this subject, this review aims to summarize the progress of recent research in antibacterial therapeutic drugs supported by nanobiotechnological tools.

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“…[4][5][6] The utilization of a tunable spatial architecture comprising vesicles, drug conjugates and complexes, dendrimers, micelles, carbon nanotubes, and core-shell particles facilitates an improved level of interaction between nanomaterials and biological systems. [7][8][9][10] The achievement of tunability and precision of these functional nanoarchitectures are reliant upon the involvement of a surfactant in the process. 11 Surface modifications that result in nanostructures are frequently employed in diagnostic applications by means of conjugation, which involves the incorporation of diagnostic and therapeutic moieties.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin and doxorubicin mediated nanoarchitectonics of copper clusters: a bimodal theranostics for cancer diagnosis and treatment in vitro

Joseph,

Rahman Pathiripparambath,

Thomas

et al. 2024

J. Mater. Chem. B

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Nanoarchitectonics is an emerging drug/gene delivery and targeting strategy -a critical review

Cited by 13 publications

References 117 publications

Advances in Nanoarchitectonics: A Review of “Static” and “Dynamic” Particle Assembly Methods

Advances in Nanoarchitectonics: A Review of “Static” and “Dynamic” Particle Assembly Methods

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

Porphyrin and doxorubicin mediated nanoarchitectonics of copper clusters: a bimodal theranostics for cancer diagnosis and treatment in vitro

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