Nanoaggregates of iron poly-oxo-clusters obtained by laser ablation in aqueous solution of phosphonates

Fracasso, Giulio; Ghigna, Paolo; Nodari, Luca; Agnoli, Stefano; Badocco, Denis; Pastore, Paolo; Nicolato, Elena; Marzola, Pasquina; Mihajlović, Dušan; Marković, Milan; Čolić, Miodrag; Amendola, Vincenzo

doi:10.1016/j.jcis.2018.03.065

Cited by 14 publications

(12 citation statements)

References 63 publications

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“…Although LASiS is an interesting technique for materials of different structures and compositions, this method carries problems depending on the solvent used, such as the difficulty of controlling particle size and their clustering [ 64 ]. Recent experiments, however, revealed that the use of laser ablation on phosphonates aqueous solution and bulk iron was successful in decreasing the size of FeO x crystal to few atom clusters [ 65 ].…”

Section: Synthesis Of Ionpsmentioning

confidence: 99%

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

et al. 2018

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Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.

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Section: Synthesis Of Ionpsmentioning

confidence: 99%

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

et al. 2018

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“…Internalization of NPs (blue‐stained intracellular granules) was checked using a semiquantitative method as described in previous article. [ 44 ]…”

Section: Methodsmentioning

confidence: 99%

“…To improve image quality, contrast agents such as magnetic NPs are used to significantly aid the detection and differentiation of lesions from healthy tissues. [ 5,39,41,44,45 ]…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Iron–Boron Nanoparticles Designed for Neutron Capture Therapy Guided by Magnetic Resonance Imaging

Torresan

Guadagnini

Badocco

et al. 2020

Adv Healthcare Materials

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The combination of multiple functions in a single nanoparticle (NP) represents a key advantage of nanomedicine compared to traditional medical approaches. This is well represented by radiotherapy in which the dose of ionizing radiation should be calibrated on sensitizers biodistribution. Ideally, this is possible when the drug acts both as radiation enhancer and imaging contrast agent. Here, an easy, one‐step, laser‐assisted synthetic procedure is used to generate iron–boron (Fe–B) NPs featuring the set of functions required to assist neutron capture therapy (NCT) with magnetic resonance imaging. The Fe–B NPs exceed by three orders of magnitude the payload of boron isotopes contained in clinical sensitizers. The Fe–B NPs have magnetic properties of interest also for magnetophoretic accumulation in tissues and magnetic hyperthermia to assist drug permeation in tissues. Besides, Fe–B NPs are biocompatible and undergo slow degradation in the lysosomal environment that facilitates in vivo clearance through the liver–spleen–kidneys pathway. Overall, the Fe–B NPs represent a new promising tool for future exploitation in magnetic resonance imaging‐guided boron NCT at higher levels of efficacy and tolerability.

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“…Physical Pulsed laser ablation [6,[39][40][41]] Pyrolysis [6] Chemical Co-precipitation [3,6,16,[36][37][38][40][41][42][43]] Microemulsion [6,37,44] Hydrothermal and solvothermal syntheses [1,3,6,38] Thermal decomposition [6,38] Sol-gel synthesis [3,16,17,21,32,37,38,[43][44][45][46]] Sonochemical [43,47] Microwave-assisted synthesis [6,48] Biological Biosynthesis [6,49] The synthesis of these nanoparticles into formulations should also be considered. These methodologies aim for the production of IOMNPs with improved characteristics of stability, biocompatibility, high dispersibility, suitable shape, and controlled size [1,3,6,17].…”

Section: Methods Referencesmentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

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Nanoaggregates of iron poly-oxo-clusters obtained by laser ablation in aqueous solution of phosphonates

Cited by 14 publications

References 63 publications

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Biocompatible Iron–Boron Nanoparticles Designed for Neutron Capture Therapy Guided by Magnetic Resonance Imaging

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

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